{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:37:59Z","timestamp":1792183079272,"version":"4.4.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    is a Gram-negative pathogen that has become a worldwide concern due to the emergence of multidrug-resistant isolates responsible for various invasive infectious diseases. Biofilm formation constitutes a major virulence factor for\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    and relies on the expression of fimbrial adhesins and aggregation of bacterial cells on biotic or abiotic surfaces in a coordinated manner. During biofilm aggregation, bacterial cells communicate with each other through inter- or intra-species interactions mediated by signallng molecules, called autoinducers, in a mechanism known as quorum sensing (QS). In most Gram-negative bacteria, intra-species communication typically involves the LuxI\/LuxR system: LuxI synthase produces\n                    <jats:italic>N<\/jats:italic>\n                    -acyl homoserine lactones (AHLs) as autoinducers and the LuxR transcription factor is their cognate receptor. However,\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    does not produce AHL but encodes SdiA, an orphan LuxR-type receptor that responds to exogenous AHL molecules produced by other bacterial species. While SdiA regulates several cellular processes and the expression of virulence factors in many pathogens, the role of this regulator in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    remains unknown. In this study, we describe the characterization of\n                    <jats:italic>sdiA<\/jats:italic>\n                    mutant strain of\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . The\n                    <jats:italic>sdiA<\/jats:italic>\n                    mutant strain has increased biofilm formation, which correlates with the increased expression of type 1 fimbriae, thus revealing a repressive role of SdiA in fimbriae expression and bacterial cell adherence and aggregation. On the other hand, SdiA acts as a transcriptional activator of cell division machinery assembly in the septum, since cells lacking SdiA regulator exhibited a filamentary shape rather than the typical rod shape. We also show that\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    cells lacking SdiA regulator present constant production of QS autoinducers at maximum levels, suggesting a putative role for SdiA in the regulation of AI-2 production. Taken together, our results demonstrate that SdiA regulates cell division and the expression of virulence factors such as fimbriae expression, biofilm formation, and production of QS autoinducers in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2021.597735","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:52:21Z","timestamp":1624236741000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":95,"title":["SdiA, a Quorum-Sensing Regulator, Suppresses Fimbriae Expression, Biofilm Formation, and Quorum-Sensing Signaling Molecules Production in Klebsiella pneumoniae"],"prefix":"10.3389","volume":"12","author":[{"given":"Thaisy","family":"Pacheco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana \u00c9rika In\u00e1cio","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Maria Gon\u00e7alves","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Assoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Darrieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrietta","family":"Venter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facio F\u00e1bio Caldas","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/mmi.12738","article-title":"Direct regulation of the pefI-srgC operon encoding the Rck invasin by the quorum-sensing regulator SdiA in Salmonella Typhimurium.","volume":"94","author":"Abed","year":"2014","journal-title":"Mol. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/j.1365-2958.2004.04054.x","article-title":"Cell-to-cell signalling in Escherichia coli and Salmonella enterica.","volume":"52","author":"Ahmer","year":"2004","journal-title":"Mol. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4161\/viru.22974","article-title":"Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation.","volume":"4","author":"Alc\u00e1ntar-Curiel","year":"2013","journal-title":"Virulence"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1099\/mic.0.038794-0","article-title":"Quorum sensing in bacterial virulence.","volume":"156","author":"Antunes","year":"2010","journal-title":"Microbiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1128\/JB.187.8.2870-2880.2005","article-title":"Characterization of type 2 quorum sensing in Klebsiella pneumoniae and relationship with biofilm formation.","volume":"187","author":"Balestrino","year":"2005","journal-title":"J. Bacteriol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1365-2958.1993.tb01737.x","article-title":"Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence.","volume":"9","author":"Bassler","year":"1993","journal-title":"Mol. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/genes9050253","article-title":"Role of SdiA on biofilm formation by atypical enteropathogenic Escherichia coli.","volume":"9","author":"Culler","year":"2018","journal-title":"Genes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.resmic.2010.05.014","article-title":"Quorum sensing affects biofilm formation through lipopolysaccharide synthesis in Klebsiella pneumoniae.","volume":"161","author":"De Araujo","year":"2010","journal-title":"Res. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1128\/jb.183.18.5239-5247.2001","article-title":"DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli.","volume":"183","author":"DeLisa","year":"2001","journal-title":"J. Bacteriol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008946","article-title":"E. coli K-12 and EHEC genes regulated by SdiA.","volume":"5","author":"Dyszel","year":"2010","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1073\/pnas.81.13.4154","article-title":"Identification of genes and gene products necessary for bacterial bioluminescence.","volume":"81","author":"Engebrecht","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1128\/JB.188.9.3169-3171.2006","article-title":"The QscR quorum-sensing regulon of Pseudomonas aeruginosa: an orphan claims its identity.","volume":"188","author":"Fuqua","year":"2006","journal-title":"J. Bacteriol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"7142","DOI":"10.1128\/AEM.00950-09","article-title":"Acyl-homoserine lactones can induce virus production in lysogenic bacteria: an alternative paradigm for prophage induction.","volume":"75","author":"Ghosh","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.601921","article-title":"Functional insights from Kpfr, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity.","volume":"11","author":"Gomes","year":"2021","journal-title":"Front. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27420-2","article-title":"Selection and validation of reference genes for gene expression studies in Klebsiella pneumoniae using Reverse Transcription Quantitative real-time PCR.","volume":"8","author":"Gomes","year":"2018","journal-title":"Sci. Rep."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2557-x","article-title":"Transcriptional profiling of Klebsiella pneumoniae defines signatures for planktonic, sessile and biofilm-dispersed cells.","volume":"17","author":"Guilhen","year":"2016","journal-title":"BMC Genom."},{"key":"B17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrmicro821","article-title":"Bacterial biofilms: from the natural environment to infectious diseases.","volume":"2","author":"Hall-Stoodley","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"E3574","DOI":"10.1073\/pnas.1501049112","article-title":"Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.","volume":"112","author":"Holt","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B19","doi-asserted-by":"publisher","first-page":"9831","DOI":"10.1073\/pnas.1002551107","article-title":"Chemical sensing in mammalian host-bacterial commensal associations.","volume":"107","author":"Hughes","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01451-06","article-title":"Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologue.","volume":"73","author":"Janssens","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1128\/JB.181.1.9-14.1999","article-title":"Metabolic alarms and cell division in Escherichia coli.","volume":"181","author":"Joseleau-Petit","year":"1999","journal-title":"J. Bacteriol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1046\/j.1365-2958.2000.02171.x","article-title":"SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7.","volume":"38","author":"Kanamaru","year":"2000","journal-title":"Mol. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/ecosalplus.ESP-0002-2013","article-title":"Cell-to-cell signaling in Escherichia coli and Salmonella.","volume":"6","author":"Kendall","year":"2014","journal-title":"EcoSal Plus"},{"key":"B24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ijantimicag.2007.06.019","article-title":"The changing face of Klebsiella pneumoniae infections in the community.","volume":"30","author":"Keynan","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B25","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1107\/S1399004713032355","article-title":"Structural insights into the molecular mechanism of Escherichia coli SdiA, a quorum-sensing receptor Acta Crystallogr.","volume":"70","author":"Kim","year":"2013","journal-title":"D Biol. Crystallogr."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190613","article-title":"The microbiota metabolite indole inhibits Salmonella virulence: involvement of the PhoPQ two-component system.","volume":"13","author":"Kohli","year":"2018","journal-title":"PLoS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1365-2958.2005.04960.x","article-title":"Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor.","volume":"59","author":"Lee","year":"2006","journal-title":"Mol. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-7-42","article-title":"Indole is an inter-species biofilm signal mediated by SdiA.","volume":"7","author":"Lee","year":"2007","journal-title":"BMC Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1128\/AEM.02081-08","article-title":"Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones.","volume":"75","author":"Lee","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.2217\/fmb.14.48","article-title":"Molecular pathogenesis of Klebsiella pneumoniae.","volume":"9","author":"Li","year":"2014","journal-title":"Fut. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s15010-010-0049-5","article-title":"Clinical and microbiological characteristics of Klebsiella pneumoniae isolates causing community-acquired urinary tract infections.","volume":"38","author":"Lin","year":"2010","journal-title":"Infection"},{"key":"B32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00007","article-title":"Quorum sensing N-acyl homoserine lactones-SdiA suppresses Escherichia coli-Pseudomonas aeruginosa conjugation through inhibiting traI expression.","volume":"7","author":"Lu","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01078","article-title":"SdiA improves the acid tolerance of E. coli by regulating GadW and GadY expression.","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.1128\/jb.183.19.5733-5742.2001","article-title":"SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities.","volume":"183","author":"Michael","year":"2001","journal-title":"J. Bacteriol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum Sensing in Bacteria.","volume":"55","author":"Miller","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev-genet-102108-134304","article-title":"Bacterial quorum-sensing network architectures.","volume":"43","author":"Ng","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":":e02429","DOI":"10.1128\/mBio.02429-14","article-title":"Structural and mechanistic roles of novel chemical ligands on the Sdia quorum-sensing transcription regulator.","volume":"6","author":"Nguyen","year":"2015","journal-title":"mBio"},{"key":"B39","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1128\/MMBR.00078-15","article-title":"Klebsiella pneumoniae: going on the offense with a strong defense.","volume":"80","author":"Paczosa","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/j.1574-6976.2009.00163.x","article-title":"Orphan LuxR regulators of quorum sensing.","volume":"33","author":"Patankar","year":"2009","journal-title":"FEMS Microbiol. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1128\/JB.00976-09","article-title":"Identification of functional LsrB-like autoinducer-2 receptors.","volume":"191","author":"Pereira","year":"2009","journal-title":"J. Bacteriol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1574-6976.2012.00345.x","article-title":"AI-2-mediated signalling in bacteria.","volume":"37","author":"Pereira","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1128\/IAI.00090-08","article-title":"Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression.","volume":"76","author":"Rosen","year":"2008","journal-title":"Infect. Immun."},{"key":"B44","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers.","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012427","article-title":"Bacterial quorum sensing: its role in virulence and possibilities for its control.","volume":"2","author":"Rutherford","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047720","article-title":"ExpI and PhzI are descendants of the long lost cognate signal synthase for SdiA.","volume":"7","author":"Sabag-Daigle","year":"2012","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1128\/AEM.00046-12","article-title":"The acyl homoserine lactone receptor. SdiA, of Escherichia coli and Salmonella enterica Serovar Typhimurium does not respond to indole.","volume":"78","author":"Sabag-Daigle","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00047","article-title":"Identification of sdiA-regulated genes in a mouse commensal strain of Enterobacter cloacae.","volume":"5","author":"Sabag-Daigle","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1046\/j.1365-2958.2001.02532.x","article-title":"The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule.","volume":"41","author":"Schauder","year":"2001","journal-title":"Mol. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-179","article-title":"Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation.","volume":"10","author":"Schroll","year":"2010","journal-title":"BMC Microbiol."},{"key":"B51","doi-asserted-by":"crossref","first-page":"15833","DOI":"10.1073\/pnas.0407229101","article-title":"Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR.","volume":"101","author":"Schuster","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1099\/mic.0.034330-0","article-title":"Evaluation of the effects of sdiA, a luxR homologue, on adherence and motility of Escherichia coli O157:H7.","volume":"156","author":"Sharma","year":"2010","journal-title":"Microbiology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/gtc.12139","article-title":"Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets.","volume":"19","author":"Shimada","year":"2014","journal-title":"Genes Cells"},{"key":"B54","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1073\/pnas.93.1.336","article-title":"Control of cell division in Escherichia coli: regulation of transcription of ftsQA involves both rpoS and SdiA-mediated autoinduction.","volume":"93","author":"Sitnikov","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B55","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1128\/JB.185.4.1357-1366.2003","article-title":"Detection of other microbial species by Salmonella: expression of the SdiA regulon.","volume":"185","author":"Smith","year":"2003","journal-title":"J. Bacteriol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002826","article-title":"SdiA, an N-acylhomoserine lactone receptor, becomes active during the transit of Salmonella enterica through the gastrointestinal tract of turtles.","volume":"3","author":"Smith","year":"2008","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1089\/fpd.2010.0651","article-title":"Eavesdropping by bacteria: the role of SdiA in Escherichia coli and Salmonella enterica serovar Typhimurium quorum sensing.","volume":"8","author":"Smith","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1574-695X.2012.00965.x","article-title":"Biofilm formation of Klebsiella pneumoniae on urethral catheters requires either type 1 or type 3 fimbriae.","volume":"65","author":"Stahlhut","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.1128\/IAI.00494-08","article-title":"Characterization of Klebsiella pneumoniae type 1 fimbriae by detection of phase variation during colonization and infection and impact on virulence.","volume":"76","author":"Struve","year":"2008","journal-title":"Infect. Immun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.1128\/IAI.00585-09","article-title":"Identification of a conserved chromosomal region encoding Klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity.","volume":"77","author":"Struve","year":"2009","journal-title":"Infect. Immun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1021\/acsinfecdis.0c00654","article-title":"Chemical control of quorum sensing in E. coli: identification of small molecule modulators of Sdia and mechanistic characterization of a covalent inhibitor.","volume":"6","author":"Styles","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1046\/j.1365-2958.1999.01199.x","article-title":"Regulation of autoinducer production in Salmonella typhimurium.","volume":"31","author":"Surette","year":"1999","journal-title":"Mol. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1093\/jac\/dkq112","article-title":"Quorum-sensing regulator sdiA and marA overexpression is involved in in vitro-selected multidrug resistance of Escherichia coli.","volume":"65","author":"Tavio","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"B64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/JB.186.3.631-637.2004","article-title":"Reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein.","volume":"186","author":"Urbanowski","year":"2004","journal-title":"J. Bacteriol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1128\/CMR.17.3.581-611.2004","article-title":"Phase and antigenic variation in bacteria.","volume":"17","author":"van der Woude","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"B66","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1002\/j.1460-2075.1991.tb04900.x","article-title":"A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli.","volume":"10","author":"Wang","year":"1991","journal-title":"Embo J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1128\/JB.187.6.2066-2076.2005","article-title":"Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.","volume":"187","author":"Wang","year":"2005","journal-title":"J. Bacteriol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1146\/annurev-chembioeng-101519-124728","article-title":"Quorum sensing communication: molecularly connecting cells, their neighbors, and even devices.","volume":"11","author":"Wang","year":"2020","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"B69","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1107\/S1744309107059696","article-title":"Crystallization and preliminary X-ray studies of SdiA from Escherichia coli Acta Crystallogr.","volume":"64","author":"Wu","year":"2008","journal-title":"Sect. F Struct. Biol. Cryst. Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1128\/JB.187.1.238-248.2005","article-title":"Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.","volume":"187","author":"Xavier","year":"","journal-title":"J. Bacteriol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nature03960","article-title":"Interference with AI-2-mediated bacterial cell-cell communication.","volume":"437","author":"Xavier","year":"","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1046\/j.1365-2958.2001.02585.x","article-title":"Novel mode of transcription regulation by SdiA, an Escherichia coli homologue of the quorum-sensing regulator.","volume":"41","author":"Yamamoto","year":"2001","journal-title":"Mol. Microbiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jmb.2005.10.041","article-title":"Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones.","volume":"355","author":"Yao","year":"2006","journal-title":"J. Mol. Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"6202","DOI":"10.1016\/j.bmcl.2007.09.029","article-title":"NMR detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli.","volume":"17","author":"Yao","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B75","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/cr.2008.67","article-title":"An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli.","volume":"18","author":"Zhou","year":"2008","journal-title":"Cell Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1073\/pnas.98.4.1507","article-title":"The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization.","volume":"98","author":"Zhu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B77","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00284-008-9140-x","article-title":"Inhibition of quorum sensing in Serratia marcescens H30 by molecular regulation.","volume":"56","author":"Zhu","year":"2008","journal-title":"Curr. Microbiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/dna.2011.1375","article-title":"The response of type 2 quorum sensing in Klebsiella pneumoniae to a fluctuating culture environment.","volume":"31","author":"Zhu","year":"2012","journal-title":"DNA Cell Biol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2021.597735\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:52:32Z","timestamp":1624236752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2021.597735\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":78,"alternative-id":["10.3389\/fmicb.2021.597735"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2021.597735","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"article-number":"597735"}}