{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:01:17Z","timestamp":1790179277017,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Candida parapsilosis<\/jats:italic> complex is one of the most common non-<jats:italic>albicans Candida<\/jats:italic> species that cause candidemia, especially invasive candidiasis. The purpose of this study was to evaluate the antifungal susceptibilities of both colonized and invasive clinical <jats:italic>C. parapsilosis<\/jats:italic> complex isolates to 10 drugs: amphotericin (AMB), anidulafungin (AFG), caspofungin (CAS), micafungin (MFG), fluconazole (FLZ), voriconazole (VRZ), itraconazole (ITZ), posaconazole (POZ), 5-flucytosine (FCY), and isaconazole (ISA). In total, 884 <jats:italic>C. parapsilosis<\/jats:italic> species complex isolates were gathered between January 2005 and December 2020. <jats:italic>C. parapsilosis<\/jats:italic>, <jats:italic>Candida metapsilosis<\/jats:italic>, and <jats:italic>Candida orthopsilosis<\/jats:italic> accounted for 86.3, 8.1, and 5.5% of the cryptic species, respectively. The resistance\/non-wild-type rate of bloodstream <jats:italic>C. parapsilosis<\/jats:italic> to the drugs was 3.5%, of <jats:italic>C. metapsilosis<\/jats:italic> to AFG and CAS was 7.7%, and of <jats:italic>C. orthopsilosis<\/jats:italic> to FLZ and VRZ was 15% and to CAS, MFG, and POZ was 5%. The geometric mean (GM) minimum inhibitory concentrations (MICs) of non-bloodstream <jats:italic>C. parapsilosis<\/jats:italic> for CAS (0.555 mg\/L), MFG (0.853 mg\/L), FLZ (0.816 mg\/L), VRZ (0.017 mg\/L), ITZ (0.076 mg\/L), and POZ (0.042 mg\/L) were significantly higher than those of bloodstream <jats:italic>C. parapsilosis<\/jats:italic>, for which the GM MICs were 0.464, 0.745, 0.704, 0.015, 0.061, and 0.033 mg\/L, respectively (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The MIC distribution of the bloodstream <jats:italic>C. parapsilosis<\/jats:italic> strains collected from 2019 to 2020 for VRZ, POZ, and ITZ were 0.018, 0.040, and 0.073 mg\/L, significantly higher than those from 2005 to 2018, which were 0.013, 0.028, and 0.052 mg\/L (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Additionally, MIC distributions of <jats:italic>C. parapsilosis<\/jats:italic> with FLZ and the distributions of <jats:italic>C. orthopsilosis<\/jats:italic> with ITZ and POZ might be higher than those in Clinical and Laboratory Standards Institute studies. Furthermore, a total of 143 <jats:italic>C. parapsilosis<\/jats:italic> complex isolates showed great susceptibility to ISA. Overall, antifungal treatment of the non-bloodstream <jats:italic>C. parapsilosis<\/jats:italic> complex isolates should be managed and improved. The clinicians are suggested to pay more attention on azoles usage for the <jats:italic>C. parapsilosis<\/jats:italic> complex isolates. In addition, establishing the epidemiological cutoff values (ECVs) for azoles used in Eastern China may offer better guidance for clinical treatments. Although ISA acts on the same target as other azoles, it may be used as an alternative therapy for cases caused by FLZ- or VRZ-resistant <jats:italic>C. parapsilosis<\/jats:italic> complex strains.<\/jats:p>","DOI":"10.3389\/fmicb.2021.644000","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T04:46:39Z","timestamp":1614833199000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence and Antifungal Susceptibility of Candida parapsilosis Species Complex in Eastern China: A 15-Year Retrospective Study by ECIFIG"],"prefix":"10.3389","volume":"12","author":[{"given":"Jian","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00264","article-title":"Molecular identification, genotypic diversity, antifungal susceptibility, and clinical outcomes of infections caused by clinically underrated yeasts, Candida orthopsilosis, and Candida metapsilosis: an iranian multicenter study (2014-2019).","volume":"9","author":"Arastehfar","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-37855-2","article-title":"High-resolution fingerprinting of Candida parapsilosis isolates suggests persistence and transmission of infections among neonatal intensive care unit patients in Kuwait.","volume":"9","author":"Asadzadeh","year":"2019","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1128\/aac.00466-11","article-title":"Prospective multicenter study of the epidemiology, molecular identification, and antifungal susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis isolated from patients with candidemia.","volume":"55","author":"Cant\u00f3n","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.09.003","article-title":"Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination.","volume":"55","author":"Castanheira","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.diagmicrobio.2016.02.009","article-title":"Antifungal susceptibility patterns of a global collection of fungal isolates: results of the SENTRY Antifungal Surveillance Program (2013).","volume":"85","author":"Castanheira","year":"2016","journal-title":"Diagn. Microbiol. Infect Dis."},{"key":"B6","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1086\/529435","article-title":"Factors associated with candidemia caused by non-albicans Candida species versus Candida albicans in the intensive care unit.","volume":"46","author":"Chow","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"B7","year":"2020","journal-title":"Epidemiological Cutoff Values for Antifungal Susceptibility Testing"},{"key":"B8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s11046-015-9916-z","article-title":"Species distribution, virulence factors, and antifungal susceptibility among Candida parapsilosis complex isolates recovered from clinical specimens.","volume":"180","author":"da Silva","year":"2015","journal-title":"Mycopathologia"},{"key":"B9","doi-asserted-by":"crossref","first-page":"e00574","DOI":"10.1128\/JCM.00574-18","article-title":"Reduction in percentage of Clusters of Candida albicans and Candida parapsilosis causing candidemia in a general hospital in Madrid, Spain.","volume":"56","author":"Escribano","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"B10","first-page":"1329","article-title":"Clinical distribution characteristics and drug resistance analysis of Klebsiella pneumoniae.","volume":"25","author":"Feng","year":"2020","journal-title":"Chin. J. Clin. Pulmonol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.4161\/viru.26973","article-title":"Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis virulence in the non-conventional host Galleria mellonella.","volume":"5","author":"Gago","year":"2014","journal-title":"Virulence"},{"key":"B12","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.diagmicrobio.2004.03.017","article-title":"Morphotypic and genotypic characterization of sequential Candida parapsilosis isolates from an outbreak in a pediatric intensive care unit.","volume":"49","author":"Garc\u00eda San Miguel","year":"2004","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.riam.2018.12.001","article-title":"Killing kinetics of anidulafungin, caspofungin and micafungin against Candida parapsilosis species complex: evaluation of the fungicidal activity.","volume":"36","author":"Gil-Alonso","year":"2019","journal-title":"Rev. Iberoam. Micol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1469-0691.2009.03020.x","article-title":"Prevalence rates and antifungal susceptibility profiles of the Candida parapsilosis species complex: results from a nationwide surveillance of candidaemia in Brazil.","volume":"16","author":"Gon\u00e7alves","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1093\/jac\/dkw091","article-title":"Emergence of azole-resistant Candida parapsilosis causing bloodstream infection: results from laboratory-based sentinel surveillance in South Africa.","volume":"71","author":"Govender","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/1469-0691.12539","article-title":"Global trends in the distribution of Candida species causing candidemia.","volume":"20","author":"Guinea","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.2217\/fmb-2017-0036","article-title":"Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing.","volume":"12","author":"Guo","year":"2017","journal-title":"China. Future Microbiol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3201\/eid1006.030873","article-title":"Candida parapsilosis characterization in an outbreak setting.","volume":"10","author":"Kuhn","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/myc.12596","article-title":"Detection of neonatal unit clusters of Candida parapsilosis fungaemia by microsatellite genotyping: results from laboratory-based sentinel surveillance, South Africa, 2009-2010.","volume":"60","author":"Magobo","year":"2017","journal-title":"Mycoses"},{"key":"B20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.riam.2018.01.004","article-title":"Species distribution and antifungal susceptibility among clinical isolates of Candida parapsilosis complex from India.","volume":"35","author":"Maria","year":"2018","journal-title":"Rev. Iberoam. Micol."},{"key":"B21","first-page":"35","article-title":"Antifungal susceptibility pattern and biofilm-related genes expression in planktonic and biofilm cells of Candida parapsilosis species complex.","volume":"5","author":"Modiri","year":"2019","journal-title":"Curr. Med. Mycol."},{"key":"B22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.riam.2016.11.005","article-title":"Molecular identification and in vitro antifungal susceptibility of blood isolates of the Candida parapsilosis species complex in Venezuela.","volume":"34","author":"Moreno","year":"2017","journal-title":"Rev. Iberoam. Micol."},{"key":"B23","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of Candidiasis: 2016 update by the infectious diseases society of America.","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis.","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/jac\/dks019","article-title":"Epidemiology, species distribution and in vitro antifungal susceptibility of fungaemia in a Spanish multicentre prospective survey.","volume":"67","author":"Pem\u00e1n","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2011.11.001","article-title":"Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.","volume":"125","author":"Pfaller","year":"2012","journal-title":"Am. J. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101510","article-title":"Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004\u22122008.","volume":"9","author":"Pfaller","year":"2014","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/ofid\/ofy358","article-title":"Twenty years of the SENTRY antifungal surveillance program: results for candida species from 1997-2016.","volume":"6","author":"Pfaller","year":"2019","journal-title":"Open Forum. Infect. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1128\/jcm.00248-12","article-title":"Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution.","volume":"50","author":"Pfaller","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijantimicag.2011.02.016","article-title":"Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in intensive care unit (ICU) and non-ICU settings in the SENTRY antimicrobial surveillance program (2008-2009).","volume":"38","author":"Pfaller","year":"","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B31","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1128\/jcm.01398-10","article-title":"Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: report from the SENTRY antimicrobial surveillance program (2008 to 2009).","volume":"49","author":"Pfaller","year":"","journal-title":"J. Clin. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s11046-013-9616-5","article-title":"Candidemia by species of the Candida parapsilosis complex in children\u2019s hospital: prevalence, biofilm production and antifungal susceptibility.","volume":"175","author":"Ruiz","year":"2013","journal-title":"Mycopathologia"},{"key":"B33","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","article-title":"Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance.","volume":"36","author":"Silva","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1093\/jac\/dkz029","article-title":"Emergence of clonal fluconazole-resistant Candida parapsilosis clinical isolates in a multicentre laboratory-based surveillance study in India.","volume":"74","author":"Singh","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01401","article-title":"Prevalence and antifungal susceptibility of pathogenic yeasts in China: a 10-year retrospective study in a teaching hospital.","volume":"11","author":"Song","year":"2020","journal-title":"Front. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3201\/eid2301.161198","article-title":"Epidemiology of hospitalizations associated with invasive Candidiasis, United States, 2002-2012(1).","volume":"23","author":"Strollo","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1128\/jcm.43.1.284-292.2005","article-title":"Candida orthopsilosis and Candida metapsilosis spp. nov. to replace Candida parapsilosis groups II and III.","volume":"43","author":"Tavanti","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02997","article-title":"An azole-resistant Candida parapsilosis outbreak: clonal persistence in the intensive care unit of a Brazilian teaching hospital.","volume":"9","author":"Thomaz","year":"2018","journal-title":"Front. Microbiol."},{"key":"B39","doi-asserted-by":"crossref","first-page":"e00111","DOI":"10.1128\/CMR.00111-18","article-title":"Candida parapsilosis: from genes to the bedside.","volume":"32","author":"T\u00f3th","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"B40","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1128\/cmr.00013-08","article-title":"Candida parapsilosis, an emerging fungal pathogen.","volume":"21","author":"Trofa","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.diagmicrobio.2008.04.019","article-title":"Significant differences in drug susceptibility among species in the Candida parapsilosis group.","volume":"62","author":"van Asbeck","year":"2008","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3109\/10408410903213393","article-title":"Candida parapsilosis: a review of its epidemiology, pathogenesis, clinical aspects, typing and antimicrobial susceptibility.","volume":"35","author":"van Asbeck","year":"2009","journal-title":"Crit. Rev. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.diagmicrobio.2011.05.014","article-title":"Microsatellite multilocus genotyping clarifies the relationship of Candida parapsilosis strains involved in a neonatal intensive care unit outbreak.","volume":"71","author":"Vaz","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.mycmed.2019.100907","article-title":"Frequency, virulence factors and antifungal susceptibility of Candida parapsilosis species complex isolated from patients with candidemia in the central region of Argentina.","volume":"29","author":"Vigezzi","year":"2019","journal-title":"J. Mycol. Med."},{"key":"B45","article-title":"Investigation of an unrecognized large-scale outbreak of Candida parapsilosis sensu stricto fungaemia in a tertiary-care hospital in China.","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1093\/infdis\/jiz573","article-title":"Distribution and antifungal susceptibility of Candida Species causing Candidemia in China: an update from the CHIF-NET study.","volume":"221","author":"Xiao","year":"2020","journal-title":"J. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1093\/jac\/dku460","article-title":"Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance.","volume":"70","author":"Xiao","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"B48","doi-asserted-by":"crossref","first-page":"e00577","DOI":"10.1128\/JCM.00577-18","article-title":"Five-year national surveillance of invasive Candidiasis: species distribution and azole susceptibility from the China hospital invasive fungal surveillance net (CHIF-NET) study.","volume":"56","author":"Xiao","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1086-6","article-title":"Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy.","volume":"15","author":"Zhang","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01320","article-title":"Molecular characterization of Candida parapsilosis by microsatellite typing and emergence of clonal antifungal drug resistant strains in a multicenter surveillance in China.","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Microbiol."},{"key":"B51","first-page":"1689","article-title":"Clinical distribution and drug resistance of Klebsiella pneumoniae in non-sputum samples.","volume":"27","author":"Zhao-Yun","year":"2017","journal-title":"Chin. J. Hosp. Infect."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2021.644000\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T04:46:57Z","timestamp":1614833217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2021.644000\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,4]]},"references-count":51,"alternative-id":["10.3389\/fmicb.2021.644000"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2021.644000","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,4]]},"article-number":"644000"}}