{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:05:56Z","timestamp":1791255956576,"version":"4.1.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1A2C200590711"],"award-info":[{"award-number":["NRF-2021R1A2C200590711"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Campylobacter<\/jats:italic>, a major foodborne pathogen, is susceptible to oxygen. Recently, aerotolerant <jats:italic>Campylobacter<\/jats:italic> with enhanced tolerance to aerobic stress has become a major concern in food safety. However, the aerotolerance of <jats:italic>Campylobacter coli<\/jats:italic> from pigs has not been studied extensively. Here, we sought to investigate the prevalence of <jats:italic>C. coli<\/jats:italic> across multiple swine groups in farms, including weaning, growing, and fattening pigs in production stages and pregnant sows. Additionally, we analyzed <jats:italic>C. coli<\/jats:italic> aerotolerance, quinolone resistance, virulence potential, and multilocus sequence typing (MLST) genotypes. Finally, we compared the characteristics of <jats:italic>C. coli<\/jats:italic> according to the aerotolerance levels. In total, we obtained 124 (66.3%) <jats:italic>C. coli<\/jats:italic> isolates from 187 swine fecal samples across six swine farms. The pathogen was prevalent in weaning (45.5%), growing (68.3%), and fattening (75.4%) pigs, and pregnant sows (66.7%). Hyper-aerotolerant HAT <jats:italic>C. coli<\/jats:italic> (13.7% of 124 isolates) was present in all swine groups, with the highest proportion in the pregnant sows (27.3%). All HAT isolates possessed diverse virulence-related genes such as <jats:italic>flaA<\/jats:italic>, <jats:italic>cadF<\/jats:italic>, <jats:italic>pldA<\/jats:italic>, <jats:italic>ceuE<\/jats:italic>, and <jats:italic>cdtA<\/jats:italic>. All <jats:italic>C. coli<\/jats:italic> isolates were resistant to quinolones, and 12 (10%) presented high-level ciprofloxacin resistance (MIC \u2265 32 \u03bcg\/mL). The proportion of <jats:italic>C. coli<\/jats:italic> isolates with a high-level ciprofloxacin resistance was the highest in HAT <jats:italic>C. coli<\/jats:italic> (18.8%). Furthermore, six MLST sequence types (STs) (ST827, ST830, ST854, ST1016, ST1068, and ST1096) of swine-derived <jats:italic>C. coli<\/jats:italic> were in common with human-derived <jats:italic>C. coli<\/jats:italic> (PubMLST). The proportion of <jats:italic>C. coli<\/jats:italic> belonging to such shared STs at each aerotolerance level was the highest in HAT <jats:italic>C. coli<\/jats:italic> (HAT vs. oxygen-sensitive; OR = 3.13). In conclusion, quinolone resistance of <jats:italic>C. coli<\/jats:italic> may be distributed throughout in all swine groups in farms. HAT <jats:italic>C. coli<\/jats:italic> is likely to remain in pig farms and re-infect other pigs in the farms. Furthermore, swine-derived HAT <jats:italic>C. coli<\/jats:italic> could be transmitted to humans easily through the food chain owing to its aerotolerance, and it could pose a threat to public health owing to its high-level ciprofloxacin resistance and virulence. This study highlights the need to develop management practices that prevent the transmission of swine-derived HAT <jats:italic>C. coli<\/jats:italic> to humans.<\/jats:p>","DOI":"10.3389\/fmicb.2021.703993","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T11:49:30Z","timestamp":1626436170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hyper-Aerotolerant Campylobacter coli From Swine May Pose a Potential Threat to Public Health Based on Its Quinolone Resistance, Virulence Potential, and Genetic Relatedness"],"prefix":"10.3389","volume":"12","author":[{"given":"Jae-Ho","family":"Guk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyokeun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saehah","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Uk","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongbeom","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4315\/0362-028x.Jfp-11-334","article-title":"Quantification of campylobacter in swine before, during, and after the slaughter process.","volume":"75","author":"Abley","year":"2012","journal-title":"J. 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