{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:28:36Z","timestamp":1793780916379,"version":"4.6.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["201704020219"],"award-info":[{"award-number":["201704020219"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>A longitudinal serological study to investigate the seropositive frequency, incidence, and antibody dynamics of<jats:italic>Chlamydia trachomatis<\/jats:italic>infection in the general population of China is urgently needed in order to optimize the strategies for surveillance and precise prevention of<jats:italic>C. trachomatis<\/jats:italic>infection. This longitudinal study enrolled 744 subjects aged 18\u201365 years from Jidong Community of Northern China from 2014 to 2018. Seropositive frequency, incidence, and reinfection of<jats:italic>C. trachomatis<\/jats:italic>were determined by detecting antibody against<jats:italic>C. trachomatis<\/jats:italic>Pgp3 using \u201cin-house\u201d luciferase immunosorbent assay (LISA). The dynamic of anti-Pgp3 antibody was analyzed using the Generalized Estimating Equation (GEE) model. The overall Pgp3 seropositive frequency among the 18\u201365-year-old population was 28.1% (95% CI 24.9\u201331.5), and significantly increased from 12.0% in those aged 18\u201329 years to 48.6% in the 60\u201365 years old. The seropositive frequency was slightly higher in women than in men (31.3% vs. 25.4%) without statistical significance. The<jats:italic>C. trachomatis<\/jats:italic>incidence and reinfection rate were 11 and 14 per 1,000 person-years, respectively, and showed no significant difference with respect to age, gender, ethnicity, marital status, and education levels. Furthermore, anti-Pgp3 antibody remained detectable in 93.3% (195\/209) of the seropositive subjects during the 5 years of follow-up. The overall decay rate for anti-Pgp3 antibody for CT-infected persons was \u22120.123 Log2 RLU\/year, which was dramatically slower than in CT new infection (\u22123.34 Log2 RLU\/year) or reinfection (\u22121.1 Log2 RLU\/year). In conclusion, at least one quarter of the people aged 18\u201365 years have been infected with<jats:italic>C. trachomatis<\/jats:italic>over their lifetime while all age groups are susceptible to<jats:italic>C. trachomatis<\/jats:italic>infection in the community of Northern China. Therefore, comprehensive prevention strategies are urgently needed.<\/jats:p>","DOI":"10.3389\/fmicb.2021.729016","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:01:41Z","timestamp":1632844901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Seroepidemiology of Chlamydia trachomatis Infection in the General Population of Northern China: The Jidong Community Cohort Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Jingwei","family":"Shui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/jama.285.1.47","article-title":"Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma.","volume":"285","author":"Anttila","year":"2001","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14121579","article-title":"Prevalence of Chlamydia trachomatis infection and its association with sexual behaviour and alcohol use in the population living in separated and segregated Roma settlements in Eastern Slovakia.","volume":"14","author":"Babinsk\u00e1","year":"2017","journal-title":"Int. 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