{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:25:51Z","timestamp":1792589151558,"version":"4.5.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Long non-coding RNAs are involved in many infectious diseases. Our previous studies showed that<jats:italic>lncRNA-ENST00000421645<\/jats:italic>expression is increased in T lymphocytes of neurosyphilis patients compared to healthy controls. However, whether<jats:italic>lncRNA-ENST00000421645<\/jats:italic>has biological functions remains unclear. The current study was undertaken to understand the mechanism of<jats:italic>lncRNA-ENST00000421645<\/jats:italic>in T lymphocyte function in neurosyphilis patients. The<jats:italic>lncRNA-ENST00000421645<\/jats:italic>pull-down assay showed that<jats:italic>lncRNA-ENST00000421645<\/jats:italic>acted on the acetylase NAT10. The chromatin immunoprecipitation (ChIP)-PCR results showed that<jats:italic>lncRNA-ENST00000421645<\/jats:italic>promoted the acetylation of histone H3K27 adjacent to the Kank1 promoter, thereby promoting Kank1 protein expression. Kank1 promotes 14-3-3 protein expression, inhibits NF-kB activation, inhibits IFN-\u03b3 secretion by T lymphocytes, and promotes T lymphocyte apoptosis. Taken together, our findings suggest a novel mechanism that<jats:italic>LncRNA-ENST00000421645<\/jats:italic>upregulates<jats:italic>Kank1<\/jats:italic>to inhibit IFN-\u03b3 expression and promote T cell apoptosis in neurosyphilis.<\/jats:p>","DOI":"10.3389\/fmicb.2021.749171","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T17:58:11Z","timestamp":1638381491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["LncRNA-ENST00000421645 Upregulates Kank1 to Inhibit IFN-\u03b3 Expression and Promote T Cell Apoptosis in Neurosyphilis"],"prefix":"10.3389","volume":"12","author":[{"given":"Kai-Xuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Lin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Cong","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Zhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Li","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ci","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1242\/jcs.03086","article-title":"Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.","volume":"119","author":"Aguilera","year":"2006","journal-title":"J. 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