{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:39:22Z","timestamp":1792877962680,"version":"4.5.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The aim of the present study is to investigate the effects of dietary <jats:italic>Lycium barbarum<\/jats:italic> polysaccharides (LBPs) supplementation on the growth performance, immune response, serum antioxidant status, and intestinal health of weaned piglets. In total, 24 crossed healthy weaned piglets [Duroc \u00d7 (Yorkshire \u00d7 Landrace)], of similar body weight (7.47 \u00b1 0.22 kg), were randomly allocated to three treatment groups: CON (basal diet); LBPs (basal diet plus 4,000 mg\/kg LBPs); and antibiotic (ABO, basal diet plus 20 mg\/kg flavomycin and 50 mg\/kg quinocetone). There were eight pigs per group. The study lasted 28 days. When compared with CON, LBPs or ABO dietary supplementation increased average daily gain (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), decreased the ratio of feed to gain and the diarrhea ratio (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Similarly, when compared with CON, LBPs dietary supplementation increased serum immunoglobulin G, immunoglobulin M, interleukin-10, interleukin-2, and tumor necrosis factor-\u03b1 levels (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Dietary LBPs enhanced the activity of serum total antioxidant capacity and glutathione peroxidase, and decreased malondialdehyde levels (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Principal component analysis showed a distinct separation between CON and LBPs groups, but no differences between ABO and LBPs groups. LBPs addition increased <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Faecalibacterium<\/jats:italic> (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) levels, while it decreased <jats:italic>Enterococcaceae<\/jats:italic> and <jats:italic>Enterobacteriaceae<\/jats:italic> (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) levels. Furthermore, when compared with the CON group, LBPs increased villus height (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) and the villus height to crypt depth ratio in the duodenum and jejunum (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Thus, dietary supplementation with LBPs improved growth performance, antioxidant capacity and immunity, regulated intestinal microbial composition, and may be used as an efficient antibiotic alternative in weaned piglet feed.<\/jats:p>","DOI":"10.3389\/fmicb.2021.819993","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:58:50Z","timestamp":1645783130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Lycium barbarum Polysaccharides as Antibiotic Substitutes Improve Growth Performance, Serum Immunity, Antioxidant Status, and Intestinal Health for Weaned Piglets"],"prefix":"10.3389","volume":"12","author":[{"given":"Yexin","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1074\/jbc.273.11.6041","article-title":"Superoxide-mediated decomposition of biological S-nitrosothiols.","volume":"273","author":"Aleryani","year":"1998","journal-title":"J. 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