{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:09:00Z","timestamp":1790096940461,"version":"4.0.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002178"],"award-info":[{"award-number":["82002178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971979"],"award-info":[{"award-number":["81971979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000024"],"award-info":[{"award-number":["32000024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Candida duobushaemulonii<\/jats:italic>, type II <jats:italic>Candida haemulonii<\/jats:italic> complex, is closely related to <jats:italic>Candida auris<\/jats:italic> and capable of causing invasive and non-invasive infections in humans. Eleven strains of <jats:italic>C<\/jats:italic>. <jats:italic>duobushaemulonii<\/jats:italic> were collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and identified using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF), VITEK 2 Yeast Identification Card (YST), and internal transcribed spacer (ITS) sequencing. Whole genome sequencing of <jats:italic>C<\/jats:italic>. <jats:italic>duobushaemulonii<\/jats:italic> was done to determine their genotypes. Furthermore, <jats:italic>C<\/jats:italic>. <jats:italic>duobushaemulonii<\/jats:italic> strains were tested by Sensititre YeastOne\u2122 and Clinical and Laboratory Institute (CLSI) broth microdilution panel for antifungal susceptibility. Three <jats:italic>C<\/jats:italic>. <jats:italic>duobushaemulonii<\/jats:italic> could not be identified by VITEK 2. All 11 isolates had high minimum inhibitory concentrations (MICs) to amphotericin B more than 2\u2009\u03bcg\/ml. One isolate showed a high MIC value of \u226564\u2009\u03bcg\/ml to 5-flucytosine. All isolates were wild type (WT) for triazoles and echinocandins. <jats:italic>FUR1<\/jats:italic> variation may result in <jats:italic>C<\/jats:italic>. <jats:italic>duobushaemulonii<\/jats:italic> with high MIC to 5-flucytosine. <jats:italic>Candida duobushaemulonii<\/jats:italic> mainly infects patients with weakened immunity, and the amphotericin B resistance of these isolates might represent a challenge to clinical treatment.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1001845","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:08:21Z","timestamp":1670224101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Antifungal susceptibility profiles and drug resistance mechanisms of clinical Candida duobushaemulonii isolates from 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