{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:02:52Z","timestamp":1790683372538,"version":"4.1.0"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Infections with the Gram-positive bacterial pathogen <jats:italic>Staphylococcus aureus<\/jats:italic> remain a major challenge for the healthcare system and demand new treatment options. The increasing antibiotic resistance of <jats:italic>S. aureus<\/jats:italic> poses additional challenges, consequently inflicting a huge strain in the society due to enormous healthcare costs. <jats:italic>S. aureus<\/jats:italic> expresses multiple molecules, including bacterial lipoproteins (Lpps), which play a role not only in immune response but also in disease pathogenesis. <jats:italic>S. aureus<\/jats:italic> Lpps, the predominant ligands of TLR2, are important for bacterial survival as they maintain the metabolic activity of the bacteria. Moreover, Lpps possess many diverse properties that are of vital importance for the bacteria. They also contribute to host cell invasion but so far their role in different staphylococcal infections has not been fully defined. In this review, we summarize the current knowledge about <jats:italic>S. aureus<\/jats:italic> Lpps and their distinct roles in various infectious disease animal models, such as septic arthritis, sepsis, and skin and soft tissue infections. The molecular and cellular response of the host to <jats:italic>S. aureus<\/jats:italic> Lpp exposure is also a primary focus.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1006765","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T10:47:04Z","timestamp":1664794024000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Staphylococcus aureus lipoproteins in infectious diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Majd","family":"Mohammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abukar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh-Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rille","family":"Pullerits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e63279","DOI":"10.1371\/journal.pone.0063279","article-title":"Staphylococcus aureus-induced G2\/M phase transition delay in host epithelial cells increases bacterial infective efficiency","volume":"8","author":"Alekseeva","year":"2013","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e0131645","DOI":"10.1371\/journal.pone.0131645","article-title":"IL-1 receptor antagonist treatment aggravates staphylococcal septic arthritis and sepsis in mice","volume":"10","author":"Ali","year":"","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1093\/infdis\/jiv212","article-title":"CTLA4 immunoglobulin but not anti-tumor necrosis factor therapy promotes staphylococcal septic arthritis in mice","volume":"212","author":"Ali","year":"","journal-title":"J. Infect. Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/art.38902","article-title":"Antibiotic-killed Staphylococcus aureus induces destructive arthritis in mice","volume":"67","author":"Ali","year":"","journal-title":"Arthritis Rheumatol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1126\/science.285.5428.736","article-title":"Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2","volume":"285","author":"Aliprantis","year":"1999","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e00195","DOI":"10.1128\/JB.00195-19","article-title":"Copper-induced expression of a transmissible lipoprotein intramolecular Transacylase alters lipoprotein acylation and the toll-like receptor 2 response to listeria monocytogenes","volume":"201","author":"Armbruster","year":"2019","journal-title":"J. Bacteriol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/JB.01000-07","article-title":"Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands","volume":"190","author":"Baba","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ijmm.2017.08.002","article-title":"Impact of cell wall peptidoglycan O-acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis","volume":"307","author":"Baranwal","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.1128\/JB.00642-09","article-title":"Role of the twin-arginine translocation pathway in staphylococcus","volume":"191","author":"Biswas","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1432-1033.1969.tb00707.x","article-title":"Chemical characterization, spatial distribution and function of a lipoprotein (murein-lipoprotein) of the E. coli cell wall. The specific effect of trypsin on the membrane structure","volume":"10","author":"Braun","year":"1969","journal-title":"Eur. J. Biochem."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1126\/science.285.5428.732","article-title":"Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors","volume":"285","author":"Brightbill","year":"1999","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"13831","DOI":"10.1073\/pnas.0603072103","article-title":"Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins","volume":"103","author":"Bubeck Wardenburg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/femsre\/fuu006","article-title":"The molecular mechanism of bacterial lipoprotein modification\u2013how, when and why?","volume":"39","author":"Buddelmeijer","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/21505594.2021.1878688","article-title":"Pathogenicity and virulence of Staphylococcus aureus","volume":"12","author":"Cheung","year":"2021","journal-title":"Virulence"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"8356","DOI":"10.1128\/JB.186.24.8356-8362.2004","article-title":"Involvement of SirABC in iron-siderophore import in Staphylococcus aureus","volume":"186","author":"Dale","year":"2004","journal-title":"J. Bacteriol."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0061-2019","article-title":"Immune evasion by Staphylococcus aureus","volume":"7","author":"de Jong","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/9554","article-title":"Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis","volume":"5","author":"Deng","year":"1999","journal-title":"Nat. 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Cell. Infect. Microbiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/infdis\/jir266","article-title":"The combination of a tumor necrosis factor inhibitor and antibiotic alleviates staphylococcal arthritis and sepsis in mice","volume":"204","author":"Fei","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrmicro3161","article-title":"Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus","volume":"12","author":"Foster","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1128\/CMR.18.3.521-540.2005","article-title":"Recognition of Staphylococcus aureus by the innate immune system","volume":"18","author":"Fournier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e01619","DOI":"10.1128\/mBio.01619-20","article-title":"Lipoprotein N-acylation in Staphylococcus aureus is catalyzed by a two-component acyl transferase system","volume":"11","author":"Gardiner","year":"2020","journal-title":"MBio"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0140-6736(97)09522-6","article-title":"Septic arthritis","volume":"351","author":"Goldenberg","year":"1998","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"28815","DOI":"10.1074\/jbc.M704602200","article-title":"Heme coordination by Staphylococcus aureus IsdE","volume":"282","author":"Grigg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.micinf.2011.11.001","article-title":"A battle for iron: host sequestration and Staphylococcus aureus acquisition","volume":"14","author":"Haley","year":"2012","journal-title":"Microbes Infect."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-micro-090110-102851","article-title":"Molecular mechanisms of Staphylococcus aureus iron acquisition","volume":"65","author":"Hammer","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/intimm\/dxh374","article-title":"Lipoprotein is a predominant toll-like receptor 2 ligand in Staphylococcus aureus cell wall components","volume":"18","author":"Hashimoto","year":"","journal-title":"Int. Immunol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.4049\/jimmunol.177.5.3162","article-title":"Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus","volume":"177","author":"Hashimoto","year":"","journal-title":"J. Immunol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1128\/JB.181.5.1436-1443.1999","article-title":"Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus","volume":"181","author":"Heinrichs","year":"1999","journal-title":"J. Bacteriol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e96416","DOI":"10.1371\/journal.pone.0096416","article-title":"Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates","volume":"9","author":"Hilmi","year":"2014","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0171-2985(88)80036-6","article-title":"Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues","volume":"177","author":"Hoffmann","year":"1988","journal-title":"Immunobiology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0340-904X(79)80015-9","article-title":"Stimulation of humoral immunity by peptidoglycan monomer from Brevibacterium divaricatum","volume":"155","author":"Hrsak","year":"1979","journal-title":"Z. Immunitatsforsch. Immunobiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1016\/j.biopha.2017.09.058","article-title":"Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice","volume":"95","author":"Huang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"564699","DOI":"10.3389\/fimmu.2020.564699","article-title":"Bacterial lipoproteins induce BAFF production via TLR2\/MyD88\/JNK signaling pathways in dendritic cells","volume":"11","author":"Im","year":"2020","journal-title":"Front. Immunol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"10891","DOI":"10.1038\/s41598-020-67928-0","article-title":"Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice","volume":"10","author":"Jarneborn","year":"2020","journal-title":"Sci. Rep."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3390\/pathogens10020158","article-title":"Bacteria and host interplay in Staphylococcus aureus septic arthritis and sepsis","volume":"10","author":"Jin","year":"2021","journal-title":"Pathogens"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.bbrc.2011.02.069","article-title":"The role of phagocytosis in IL-8 production by human monocytes in response to lipoproteins on Staphylococcus aureus","volume":"406","author":"Kang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.molimm.2014.12.016","article-title":"Lipoprotein in the cell wall of Staphylococcus aureus is a major inducer of nitric oxide production in murine macrophages","volume":"65","author":"Kim","year":"2015","journal-title":"Mol. Immunol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1002\/jbmr.1973","article-title":"Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation","volume":"28","author":"Kim","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"7099","DOI":"10.3390\/ijms22137099","article-title":"Lipoproteins are responsible for the pro-inflammatory property of Staphylococcus aureus extracellular vesicles","volume":"22","author":"Kopparapu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1128\/IAI.00682-10","article-title":"Lipoproteins of bacterial pathogens","volume":"79","author":"Kovacs-Simon","year":"2011","journal-title":"Infect. Immun."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"11018","DOI":"10.1073\/pnas.1502026112","article-title":"Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)","volume":"112","author":"Koymans","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref47","first-page":"136","article-title":"Immunological activity of the peptidoglycan","volume":"149","author":"Krause","year":"1975","journal-title":"Z. Immunitatsforsch. Exp. Klin. Immunol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1046\/j.1365-2567.1997.00365.x","article-title":"A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccous aureus in human monocytes","volume":"92","author":"Kreutz","year":"1997","journal-title":"Immunology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00281-011-0292-6","article-title":"Innate and adaptive immune responses against Staphylococcus aureus skin infections","volume":"34","author":"Krishna","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e00525","DOI":"10.1002\/mbo3.525","article-title":"Aspartate tightens the anchoring of staphylococcal lipoproteins to the cytoplasmic membrane","volume":"6","author":"Kumari","year":"2017","journal-title":"Microbiology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/s0140-6736(00)04403-2","article-title":"Whole genome sequencing of meticillin-resistant Staphylococcus aureus","volume":"357","author":"Kuroda","year":"2001","journal-title":"Lancet"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1128\/JB.00314-12","article-title":"Environment-mediated accumulation of diacyl lipoproteins over their triacyl counterparts in Staphylococcus aureus","volume":"194","author":"Kurokawa","year":"2012","journal-title":"J. Bacteriol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"8406","DOI":"10.1074\/jbc.M809618200","article-title":"The Triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for toll-like receptor 2","volume":"284","author":"Kurokawa","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"105364","DOI":"10.1016\/j.micpath.2021.105364","article-title":"Staphylococcus aureus lipoproteins play crucial roles in inducing inflammatory responses and bacterial internalization into bovine mammary epithelial cells","volume":"162","author":"Liu","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1073\/pnas.032523999","article-title":"An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis","volume":"99","author":"Mazmanian","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2005.11.011","article-title":"MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus","volume":"24","author":"Miller","year":"2006","journal-title":"Immunity"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/intimm\/dxy016","article-title":"Mechanisms controlling nucleic acid-sensing toll-like receptors","volume":"30","author":"Miyake","year":"2018","journal-title":"Int. Immunol."},{"key":"ref59","volume-title":"Lipoproteins in","author":"Mohammad","year":"2020"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"7936","DOI":"10.1038\/s41598-020-64879-4","article-title":"The role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis","volume":"10","author":"Mohammad","year":"2020","journal-title":"Sci. Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s42003-021-01947-z","article-title":"Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing","volume":"4","author":"Mohammad","year":"2021","journal-title":"Commun. Biol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e0167287","DOI":"10.1371\/journal.pone.0167287","article-title":"RAGE deficiency impairs bacterial clearance in murine staphylococcal sepsis, but has no significant impact on staphylococcal septic arthritis","volume":"11","author":"Mohammad","year":"2016","journal-title":"PLoS One"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e1007877","DOI":"10.1371\/journal.ppat.1007877","article-title":"The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus","volume":"15","author":"Mohammad","year":"2019","journal-title":"PLoS Pathog."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1128\/IAI.01491-14","article-title":"Protective immunity against recurrent Staphylococcus aureus skin infection requires antibody and interleukin-17A","volume":"82","author":"Montgomery","year":"2014","journal-title":"Infect. Immun."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1128\/IAI.68.11.6281-6288.2000","article-title":"Molecular cloning and analysis of a putative siderophore ABC transporter from Staphylococcus aureus","volume":"68","author":"Morrissey","year":"2000","journal-title":"Infect. Immun."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1128\/IAI.00538-10","article-title":"The Staphylococcus aureus lipoprotein SitC colocalizes with toll-like receptor 2 (TLR2) in murine keratinocytes and elicits intracellular TLR2 accumulation","volume":"78","author":"Muller","year":"2010","journal-title":"Infect. Immun."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"e13153","DOI":"10.1371\/journal.pone.0013153","article-title":"Staphylococcal peptidoglycan co-localizes with Nod2 and TLR2 and activates innate immune response via both receptors in primary murine keratinocytes","volume":"5","author":"Muller-Anstett","year":"2010","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e02472","DOI":"10.1128\/mBio.02472-20","article-title":"The expression of von Willebrand factor-binding protein determines joint-invading capacity of Staphylococcus aureus, a Core mechanism of septic arthritis","volume":"11","author":"Na","year":"2020","journal-title":"MBio"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1128\/IAI.01520-15","article-title":"Deficiency of the complement component 3 but not factor B aggravates Staphylococcus aureus septic arthritis in mice","volume":"84","author":"Na","year":"2016","journal-title":"Infect. 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Rev."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"e1004984","DOI":"10.1371\/journal.ppat.1004984","article-title":"The \u03bdSa\u03b1 specific lipoprotein like cluster (lpl) of S. aureus USA300 contributes to immune stimulation and invasion in human cells","volume":"11","author":"Nguyen","year":"2015","journal-title":"PLoS Pathog."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"582582","DOI":"10.3389\/fmicb.2020.582582","article-title":"Lipoproteins in gram-positive bacteria: abundance, function, fitness","volume":"11","author":"Nguyen","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"e00343","DOI":"10.1128\/IAI.00343-18","article-title":"Toll-like receptor 2 and lipoprotein-like lipoproteins enhance Staphylococcus aureus invasion in epithelial cells","volume":"86","author":"Nguyen","year":"2018","journal-title":"Infect. 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Dis."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/82_2012_286","article-title":"What distinguishes highly pathogenic staphylococci from medium- and non-pathogenic?","volume":"358","author":"Rosenstein","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/pathogens7030064","article-title":"Staphylococcus aureus lipoprotein induces skin inflammation, accompanied with IFN-gamma-producing T cell accumulation through dermal dendritic cells","volume":"7","author":"Saito","year":"2018","journal-title":"Pathogens"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1128\/IAI.02043-14","article-title":"NOD2 stimulation by Staphylococcus aureus-derived peptidoglycan is boosted by toll-like receptor 2 costimulation with lipoproteins in dendritic cells","volume":"82","author":"Schaffler","year":"2014","journal-title":"Infect. 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Microbiol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"e00880","DOI":"10.1128\/mBio.00880-19","article-title":"Beta-lactam antibiotics enhance the pathogenicity of methicillin-resistant Staphylococcus aureus via SarA-controlled lipoprotein-like cluster expression","volume":"10","author":"Shang","year":"2019","journal-title":"MBio"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fcimb.2012.00041","article-title":"The iron-regulated staphylococcal lipoproteins","volume":"2","author":"Sheldon","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1126\/science.1099930","article-title":"Iron-source preference of Staphylococcus aureus infections","volume":"305","author":"Skaar","year":"2004","journal-title":"Science"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.immuni.2014.10.009","article-title":"Cutaneous innate immune sensing of toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells","volume":"41","author":"Skabytska","year":"2014","journal-title":"Immunity"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"132","DOI":"10.2353\/ajpath.2008.070567","article-title":"Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess","volume":"172","author":"Stenzel","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1128\/IAI.73.4.2411-2423.2005","article-title":"Staphylococcus aureus deficient in lipidation of prelipoproteins is attenuated in growth and immune activation","volume":"73","author":"Stoll","year":"2005","journal-title":"Infect. Immun."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"5325","DOI":"10.1128\/IAI.00645-06","article-title":"Staphylococcus aureus-induced corneal inflammation is dependent on toll-like receptor 2 and myeloid differentiation factor 88","volume":"74","author":"Sun","year":"2006","journal-title":"Infect. 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Chem."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.1128\/JB.01335-06","article-title":"Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization","volume":"188","author":"Torres","year":"2006","journal-title":"J. Bacteriol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"e13111","DOI":"10.1111\/cmi.13111","article-title":"Staphylococcus aureus Lpl protein triggers human host cell invasion via activation of Hsp90 receptor","volume":"22","author":"Tribelli","year":"2020","journal-title":"Cell. Microbiol."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1096\/fj.09-151001","article-title":"Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals","volume":"24","author":"Volz","year":"2010","journal-title":"FASEB J."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ijmm.2009.10.001","article-title":"The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus","volume":"300","author":"Xia","year":"2010","journal-title":"Int. J. Med. 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