{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:09:58Z","timestamp":1793286598932,"version":"4.5.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>This study was conducted to investigate the impacts of chlorogenic acid (CGA) on growth performance, intestinal permeability, intestinal digestion and absorption-related enzyme activities, immune responses, antioxidant capacity and cecum microbial composition in weaned rabbits. One hundred and sixty weaned rabbits were allotted to four treatment groups and fed with a basal diet or a basal diet supplemented with 400, 800, or 1,600\u2009mg\/kg CGA, respectively. After a 35-d trial, rabbits on the 800\u2009mg\/kg CGA-supplemented group had higher (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) ADG and lower (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) F\/G than those in control (CON) group. According to the result of growth performance, eight rabbits per group were randomly selected from the CON group and 800\u2009mg\/kg CGA group to collect serum, intestinal tissue samples and cecum chyme samples. Results showed that compared with the CON group, supplementation with 800\u2009mg\/kg CGA decreased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) levels of D-lactate, diamine oxidase, IL-1\u03b2, IL-6, and malondialdehyde (MDA), and increased IL-10 concentration in the serum; increased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) jejunal ratio of villus height to crypt depth, enhanced (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) activities of maltase and sucrase, increased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) concentrations of IL-10, T-AOC, MHCII and transforming growth factor-\u03b1, and decreased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) levels of TNF-\u03b1 and MDA in the jejunum of weaned rabbits. In addition, results of high-throughput sequencing showed that CGA supplementation elevated (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) microbial diversity and richness, and increased (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) the abundances of butyrate-producing bacteria (including genera <jats:italic>V9D2013_group<\/jats:italic>, <jats:italic>Monoglobus<\/jats:italic>, <jats:italic>Papillibacter<\/jats:italic>, <jats:italic>UCG-005<\/jats:italic>, and <jats:italic>Ruminococcus<\/jats:italic>). These results indicated that dietary supplementation with 800\u2009mg\/kg CGA could improve the growth performance of weaned rabbits by enhancing intestinal structural integrity, improving the intestinal epithelium functions, and modulating the composition and diversity of gut microbiota.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1027101","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T05:49:57Z","timestamp":1667800197000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Chlorogenic acid improves growth performance of weaned rabbits via modulating the intestinal epithelium functions and intestinal microbiota"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiali","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/1570159X17666191021111809","article-title":"Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation","volume":"18","author":"Bagdas","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e105707","DOI":"10.1371\/journal.pone.0105707","article-title":"Changes in cecal microbiota and mucosal gene expression revealed new aspects of epizootic rabbit enteropathy","volume":"9","author":"B\u00e4uerl","year":"2014","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/jpn.12058","article-title":"Morphological and functional events associated to weaning in rabbits","volume":"98","author":"Bivolarski","year":"2014","journal-title":"J. Anim. Physiol. Anim Nutr."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jns.2007.06.028","article-title":"Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects","volume":"262","author":"Bouayed","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5424\/sjar\/200806S1-5346","article-title":"New trends in rabbit feeding: influence of nutrition on intestinal health. A review","volume":"6","author":"Caraba\u00f1o","year":"2008","journal-title":"Span J. Agric. Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"574","DOI":"10.2527\/jas1988.662574x","article-title":"Effect of age, weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine","volume":"66","author":"Cera","year":"1988","journal-title":"J. Anim. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0065421","DOI":"10.1128\/Spectrum.00654-21","article-title":"Supplementation with exogenous catalase from Penicillium notatum in the diet ameliorates lipopolysaccharide-induced intestinal oxidative damage through affecting intestinal antioxidant capacity and microbiota in weaned pigs","volume":"9","author":"Chen","year":"","journal-title":"Microbiol. Spectr."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1093\/jas\/skx078","article-title":"Dietary chlorogenic acid improves growth performance of weaned pigs through maintaining antioxidant capacity and intestinal digestion and absorption function","volume":"96","author":"Chen","year":"","journal-title":"J. Anim. Sci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40104-018-0275-8","article-title":"Effects of dietary clostridium butyricum supplementation on growth performance, intestinal development, and immune response of weaned piglets challenged with lipopolysaccharide","volume":"9","author":"Chen","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3390\/antiox10121915","article-title":"Chlorogenic acid attenuates oxidative stress-induced intestinal epithelium injury by co-regulating the PI3K\/Akt and I\u03baB\u03b1\/NF-\u03baB signaling","volume":"10","author":"Chen","year":"","journal-title":"Antioxidants"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jnutbio.2018.06.005","article-title":"Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs","volume":"59","author":"Chen","year":"","journal-title":"J. Nutr. Biochem."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.1007\/s00253-019-10025-8","article-title":"Changes of porcine gut microbiota in response to dietary chlorogenic acid supplementation","volume":"103","author":"Chen","year":"2019","journal-title":"Appl. Microbiol. Biot."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"103984","DOI":"10.1016\/j.jff.2020.103984","article-title":"Neuro-protection of chlorogenic acid against Al-induced apoptosis in PC12 cells via modulation of Al metabolism and Akt\/GSK-3\u03b2 pathway","volume":"70","author":"Cheng","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pestbp.2008.03.013","article-title":"Impact of sodium cyanide on catalase activity in the freshwater exotic carp, Cyprinus carpio (Linnaeus)","volume":"92","author":"David","year":"2008","journal-title":"Pestic. Biochem. Phys."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40104-022-00673-8","article-title":"Effect of sialyllactose on growth performance and intestinal epithelium functions in weaned pigs challenged by enterotoxigenic Escherichia Coli","volume":"13","author":"Duan","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1055-937X(01)80022-0","article-title":"Normal bacterial flora of the rabbit gastrointestinal tract: a clinical approach","volume":"10","author":"Fann","year":"2001","journal-title":"Semin. Avian Exot. Pet Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1017\/S1751731107661850","article-title":"Effect of lactulose on growth performance and intestinal morphology of pre-ruminant calves using a milk replacer containing Enterococcus faecium","volume":"1","author":"Fleige","year":"2007","journal-title":"Animal"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"124618","DOI":"10.1016\/j.jhazmat.2020.124618","article-title":"Microbial diversity and activity assessment in a 100-year-old lead mine","volume":"410","author":"Gallego","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"166","DOI":"10.5455\/javar.2018.e262","article-title":"Weaning induces changes in behavior and stress indicators in young New Zealand rabbits","volume":"5","author":"Gharib","year":"2018","journal-title":"J. Adv. Vet. Anim. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1093\/jn\/133.6.1853","article-title":"Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats","volume":"133","author":"Gonthier","year":"2003","journal-title":"J. Nutr."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.neuroscience.2010.05.049","article-title":"Neuroprotective effect of 3, 5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1","volume":"169","author":"Han","year":"2010","journal-title":"Neuroscience"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"853797","DOI":"10.3389\/fmicb.2022.853797","article-title":"Increase dietary fiber intake ameliorates Cecal morphology and drives Cecal species-specific of short-chain fatty acids in white Pekin ducks","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1439-0396.2012.01284.x","article-title":"Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds","volume":"97","author":"Heo","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.2527\/jas.2012-5796","article-title":"Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs","volume":"91","author":"Hu","year":"2013","journal-title":"J. Anim. Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-food-030216-030207","article-title":"Milk glycans and their interaction with the infant-gut microbiota","volume":"9","author":"Kirmiz","year":"2018","journal-title":"Annu. Rev. Food Sci Technol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s12275-018-8024-4","article-title":"The Ruminococci: key symbionts of the gut ecosystem","volume":"56","author":"La Reau","year":"2018","journal-title":"J. Microbiol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1093\/jn\/136.5.1192","article-title":"Chlorogenic acid is absorbed in its intact form in the stomach of rats","volume":"136","author":"Lafay","year":"2006","journal-title":"J. Nutr."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"975056","DOI":"10.3389\/fmicb.2022.975056","article-title":"Supplementation with paraformic acid in the diet improved intestinal development through modulating intestinal inflammation and microbiota in broiler chickens","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/ijms21010031","article-title":"Maternal dietary fiber composition during gestation induces changes in offspring antioxidative capacity, inflammatory response, and gut microbiota in a sow model","volume":"21","author":"Li","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"733940","DOI":"10.3389\/fmedt.2021.733940","article-title":"Evaluation of fecal calprotectin, D-lactic acid and bedside gastrointestinal ultrasound image data for the prediction of acute gastrointestinal injury in sepsis patients","volume":"3","author":"Li","year":"2021","journal-title":"Front. Med. Technol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"777456","DOI":"10.3389\/fmicb.2021.777456","article-title":"Effects of clostridium butyricum on growth performance, gut microbiota and intestinal barrier function of broilers","volume":"12","author":"Li","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"916061","DOI":"10.3389\/fmicb.2022.916061","article-title":"Gut microbiome signatures in the progression of hepatitis B virus-induced liver disease","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/microorganisms8030391","article-title":"Effects of a diet supplemented with exogenous catalase from Penicillium notatum on intestinal development and microbiota in weaned piglets","volume":"8","author":"Li","year":"2020","journal-title":"Microorganisms"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl. Environ. Microb."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1111\/1541-4337.12620","article-title":"Chlorogenic acid: a comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions","volume":"19","author":"Lu","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the intestinal barrier: leukocyte\u2013epithelial cell interactions, cell junction remodeling, and mucosal repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"671683","DOI":"10.3389\/fmicb.2021.671683","article-title":"Early-life intervention using exogenous fecal microbiota alleviates gut injury and reduce inflammation caused by weaning stress in piglets","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41579-018-0036-x","article-title":"Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier","volume":"16","author":"Martens","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1079\/9781845936693.0222","article-title":"Minerals, vitamins and additives","volume":"2","author":"Mateos","year":"2010","journal-title":"Nutrit. Rabbit"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"104202","DOI":"10.1016\/j.jff.2020.104202","article-title":"Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis","volume":"75","author":"Metwally","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): a pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1023\/a:1005565708038","article-title":"Experimental ulcerative colitis impairs antioxidant defense system in rat intestine","volume":"45","author":"Nieto","year":"2000","journal-title":"Digest Dis. Sci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nri.2015.17","article-title":"Mucosal immunity to pathogenic intestinal bacteria","volume":"16","author":"Perez-Lopez","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/jpn.13595","article-title":"Thymol in fattening rabbit diet, its bioavailability and effects on intestinal morphology, microbiota from caecal content and immunity","volume":"106","author":"Placha","year":"2022","journal-title":"J. Anim. Physiol. Nutr."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00394-011-0216-1","article-title":"Plant polyphenols attenuate hepatic injury after hemorrhage\/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats","volume":"51","author":"Relja","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1021\/acs.jproteome.9b00874","article-title":"Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data","volume":"19","author":"Reynisson","year":"2020","journal-title":"J. Proteome Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e97815","DOI":"10.1371\/journal.pone.0097815","article-title":"Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS","volume":"9","author":"Ruan","year":"2014","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1002\/eji.201546237","article-title":"Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses","volume":"46","author":"Simon","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"G352","DOI":"10.1152\/ajpgi.00081.2009","article-title":"Early weaning stress impairs development of mucosal barrier function in the porcine intestine","volume":"298","author":"Smith","year":"2010","journal-title":"Am. J. Physiol. Gastr. Liver Physiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1111\/1750-3841.15744","article-title":"Protective effect against d-gal-induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion","volume":"86","author":"Tian","year":"2021","journal-title":"J. Food Sci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/7092032","article-title":"Gut microbiota, diet, and chronic diseases: the role played by oxidative stress","volume":"2019","author":"Vasquez","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"19495","DOI":"10.1038\/s41598-021-99028-y","article-title":"The value of gut microbiota to predict feed efficiency and growth of rabbits under different feeding regimes","volume":"11","author":"Velasco-Galilea","year":"2021","journal-title":"Sci. Rep."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"104248","DOI":"10.1016\/j.jff.2020.104248","article-title":"New insights in intestinal oxidative stress damage and the health intervention effects of nutrients: a review","volume":"75","author":"Wang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"799602","DOI":"10.3389\/fmicb.2022.799602","article-title":"Characteristics of the gut microbiome and its relationship with peripheral CD4+ T cell subpopulations and cytokines in rheumatoid arthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"5751","DOI":"10.3390\/ijms20225751","article-title":"Chitosan ameliorates DSS-induced ulcerative colitis mice by enhancing intestinal barrier function and improving microflora","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.1039\/d0fo01105c","article-title":"Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice","volume":"11","author":"Xu","year":"2020","journal-title":"Food Funct."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41467-017-00496-6","article-title":"The cytoplasmic nuclear receptor RAR\u03b3 controls RIP1 initiated cell death when cIAP activity is inhibited","volume":"8","author":"Xu","year":"2017","journal-title":"Nat. Commun."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3390\/biology11060840","article-title":"Antagonization of ghrelin suppresses muscle protein deposition by altering gut microbiota and serum amino acid composition in a pig model","volume":"11","author":"Yan","year":"2022","journal-title":"Biology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3389\/fimmu.2020.01125","article-title":"Chlorogenic acid protects against indomethacin-induced inflammation and mucosa damage by decreasing bacteroides-derived LPS","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Immunol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-1-0716-0266-9_8","article-title":"CD4+ T-cell differentiation in vitro","volume":"2111","author":"Yang","year":"2020","journal-title":"T-Cell Recept. Signal."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40104-021-00586-y","article-title":"Oral administration of Moringa oleifera leaf powder relieves oxidative stress, modulates mucosal immune response and cecal microbiota after exposure to heat stress in New Zealand white rabbits","volume":"12","author":"Yasoob","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"104640","DOI":"10.1016\/j.jff.2021.104640","article-title":"Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-\u03baB signaling pathway","volume":"85","author":"Yu","year":"2021","journal-title":"J. Funct. 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