{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:27:52Z","timestamp":1789586872566,"version":"build-2803163510"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Candida albicans (<jats:italic>C. albicans<\/jats:italic>) is the most common causative agent of invasive fungal infections in hospitals. The body defends against and eliminates <jats:italic>C. albicans<\/jats:italic> infection by various mechanisms of immune response, and the latter mechanism of immune evasion is a major challenge in the clinical management of <jats:italic>C. albicans<\/jats:italic> infection. The role of macrophages in combating <jats:italic>C. albicans<\/jats:italic> infection has only recently been recognized, but the mechanisms remain to be elucidated. This review focuses on the interaction between <jats:italic>C. albicans<\/jats:italic> and macrophages (macrophages), which causes the body to generate an immune response or <jats:italic>C. albicans<\/jats:italic> immune escape, and then regulates the body\u2019s immune microenvironment, to explore the effect of <jats:italic>C. albicans<\/jats:italic> virulence resistance vs. macrophage killing and clarify the role and mechanism of <jats:italic>C. albicans<\/jats:italic> pathogenesis. In general, a thorough understanding of the molecular principles driving antifungal drug resistance is essential for the development of innovative treatments that can counteract both existing and emerging fungal threats.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1029966","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T04:56:17Z","timestamp":1668747377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuo","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3030031","article-title":"Macrophage migration is impaired within Candida albicans biofilms.","volume":"3","author":"Alonso","year":"2017","journal-title":"J. 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