{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:26:24Z","timestamp":1793467584812,"version":"4.5.0"},"reference-count":165,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Biofilm formation is a fundamental part of life cycles of bacteria which affects various aspects of bacterial-host interactions including the development of drug resistance and chronic infections. In clinical settings, biofilm-related infections are becoming increasingly difficult to treat due to tolerance to antibiotics. Bacterial biofilm formation is regulated by different external and internal factors, among which quorum sensing (QS) signals and nucleotide-based second messengers play important roles. In recent years, different kinds of anti-biofilm agents have been discovered, among which are the Chinese herbal medicines (CHMs). CHMs or traditional Chinese medicines have long been utilized to combat various diseases around the world and many of them have the ability to inhibit, impair or decrease bacterial biofilm formation either through regulation of bacterial QS system or nucleotide-based second messengers. In this review, we describe the research progresses of different chemical classes of CHMs on the regulation of bacterial biofilm formation. Though the molecular mechanisms on the regulation of bacterial biofilm formation by CHMs have not been fully understood and there are still a lot of work that need to be performed, these studies contribute to the development of effective biofilm inhibitors and will provide a novel treatment strategy to control biofilm-related infections.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1039297","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:20:26Z","timestamp":1667884826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Recent advances on the regulation of bacterial biofilm formation by herbal medicines"],"prefix":"10.3389","volume":"13","author":[{"given":"Meimei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liancheng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.3390\/molecules26247635","article-title":"Anti-pathogenic properties of the combination of a T3SS inhibitory halogenated Pyrrolidone with C-30 Furanone","volume":"26","author":"Aburto-Rodr\u00edguez","year":"2021","journal-title":"Molecules"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e28351","DOI":"10.1371\/journal.pone.0028351","article-title":"Complex c-di-GMP signaling networks mediate transition between virulence properties and biofilm formation in salmonella enterica serovar Typhimurium","volume":"6","author":"Ahmad","year":"2011","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/mmi.12428","article-title":"The EAL-like protein STM1697 regulates virulence phenotypes, motility and biofilm formation in salmonella typhimurium","volume":"90","author":"Ahmad","year":"2013","journal-title":"Mol. 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Bacteriol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/joim.12782","article-title":"Biofilm formation\u2014what we can learn from recent developments","volume":"284","author":"Bjarnsholt","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-cellbio-101011-155705","article-title":"Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems","volume":"28","author":"Boyd","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"20321","DOI":"10.1038\/srep20321","article-title":"The quorum sensing inhibitor Hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release","volume":"6","author":"Brackman","year":"2016","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3389\/fphar.2020.01249","article-title":"Resveratrol modulates the gut microbiota and inflammation to protect against diabetic nephropathy in mice","volume":"11","author":"Cai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1126\/science.1121357","article-title":"Bacterial small-molecule signaling pathways","volume":"311","author":"Camilli","year":"2006","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s12032-021-01611-w","article-title":"Combination of resveratrol and BIBR1532 inhibits proliferation of colon cancer cells by repressing expression of LncRNAs","volume":"39","author":"Cesmeli","year":"2021","journal-title":"Med. 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Int."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.tim.2017.09.003","article-title":"A delicate connection: c-di-AMP affects cell integrity by controlling Osmolyte transport","volume":"26","author":"Commichau","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.3390\/molecules25102462","article-title":"The world of cyclic Dinucleotides in bacterial behavior","volume":"25","author":"da Aline Dias","year":"2020","journal-title":"Molecules"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.femsre.2003.09.004","article-title":"Quorum sensing and swarming migration in bacteria","volume":"28","author":"Daniels","year":"2004","journal-title":"FEMS Microbiol. 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Interfaces"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"5588","DOI":"10.3390\/ijms20225588","article-title":"Plant-derived inhibitors of AHL-mediated quorum sensing in bacteria: modes of action","volume":"20","author":"Deryabin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1039\/b804469b","article-title":"Quorum sensing and bacterial biofilms","volume":"27","author":"Dickschat","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00253-010-2471-0","article-title":"Chemoinformatics-assisted development of new anti-biofilm compounds","volume":"87","author":"D\u00fcrig","year":"2010","journal-title":"Appl. Microbiol. 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Microbiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e00817-20","DOI":"10.1128\/mSystems.00817-20","article-title":"The protein-protein interaction network reveals a novel role of the signal transduction protein PII in the control of c-di-GMP homeostasis in Azospirillum brasilense","volume":"5","author":"Gerhardt","year":"2020","journal-title":"mSystems"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijfoodmicro.2008.03.028","article-title":"Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria","volume":"125","author":"Girennavar","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e0134684","DOI":"10.1371\/journal.pone.0134684","article-title":"Quercetin influences quorum sensing in food borne bacteria: in-vitro and in-Silico evidence","volume":"10","author":"Gopu","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1128\/iai.00447-16","article-title":"Cyclic di-AMP released from Staphylococcus aureus biofilm induces a macrophage type I interferon response","volume":"84","author":"Gries","year":"2016","journal-title":"Infect. Immun."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3389\/fmicb.2016.00804","article-title":"Second messenger signaling in Bacillus subtilis: accumulation of cyclic di-AMP inhibits biofilm formation","volume":"7","author":"Gundlach","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.vetmic.2014.09.021","article-title":"Andrographolide interferes quorum sensing to reduce cell damage caused by avian pathogenic Escherichia coli","volume":"174","author":"Guo","year":"2014","journal-title":"Vet. Microbiol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/jam.13892","article-title":"Quorum-sensing inhibitor potential of trans-anethole aganist Pseudomonas aeruginosa","volume":"125","author":"Han\u00e7er Aydemir","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.3390\/ijms22094946","article-title":"EGCG-mediated potential inhibition of biofilm development and quorum sensing in Pseudomonas aeruginosa","volume":"22","author":"Hao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0167-4838(01)00187-x","article-title":"Allosteric regulation of the cAMP receptor protein","volume":"1547","author":"Harman","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"850030","DOI":"10.3389\/fcimb.2022.850030","article-title":"Combination therapies for biofilm inhibition and eradication: a comparative review of laboratory and preclinical studies","volume":"12","author":"Hawas","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1007\/s00284-020-02083-3","article-title":"Virulence conferred by PumA toxin from the plasmid-encoded PumAB toxin-antitoxin system is regulated by quorum system","volume":"77","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2020","journal-title":"Curr. Microbiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1128\/jb.00652-16","article-title":"The Catabolite repressor protein-cyclic AMP complex regulates csgD and biofilm formation in uropathogenic Escherichia coli","volume":"198","author":"Hufnagel","year":"2016","journal-title":"J. Bacteriol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"6681","DOI":"10.3390\/molecules26216681","article-title":"Labdane Diterpenoids from Salvia tingitana Etl. Synergize with clindamycin against methicillin-resistant Staphylococcus aureus","volume":"26","author":"Iobbi","year":"2021","journal-title":"Molecules"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-3-540-75418-3_4","article-title":"Quorum sensing and microbial biofilms","volume":"322","author":"Irie","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"103698","DOI":"10.1016\/j.micpath.2019.103698","article-title":"Total alkaloids of Sophora alopecuroides and matrine inhibit auto-inducer 2 in the biofilms of Staphylococcus epidermidis","volume":"136","author":"Jia","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"105358","DOI":"10.1016\/j.phrs.2020.105358","article-title":"Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites","volume":"164","author":"Jing","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"38126","DOI":"10.1038\/srep38126","article-title":"Plant phenolic volatiles inhibit quorum sensing in pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins","volume":"6","author":"Joshi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e0324921","DOI":"10.1128\/mbio.03249-21","article-title":"A novel locally c-di-GMP-controlled exopolysaccharide synthase required for bacteriophage N4 infection of Escherichia coli","volume":"12","author":"Junkermeier","year":"2021","journal-title":"MBio"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1007\/s00253-017-8709-3","article-title":"The specific effect of gallic acid on Escherichia coli biofilm formation by regulating pgaABCD genes expression","volume":"102","author":"Kang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1128\/jb.185.16.4693-4698.2003","article-title":"Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity","volume":"185","author":"Kaplan","year":"2003","journal-title":"J. Bacteriol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1002\/ptr.5713","article-title":"Efficacy of trans-cinnamaldehyde and Eugenol in reducing Acinetobacter baumannii adhesion to and invasion of human keratinocytes and controlling wound infection in vitro","volume":"30","author":"Karumathil","year":"2016","journal-title":"Phytother. Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm Matrixome: extracellular components in structured microbial communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-2004-815449","article-title":"Suppression of infection-induced endotoxin shock in mice by a citrus flavanone naringin","volume":"70","author":"Kawaguchi","year":"","journal-title":"Planta Med."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1248\/bpb.27.679","article-title":"A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice","volume":"27","author":"Kawaguchi","year":"","journal-title":"Biol. Pharm. Bull."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"25318","DOI":"10.1038\/srep25318","article-title":"Raffinose, a plant galactoside, inhibits Pseudomonas aeruginosa biofilm formation via binding to LecA and decreasing cellular cyclic diguanylate levels","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1124\/mol.107.044164","article-title":"Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening","volume":"73","author":"Kiran","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1046\/j.1365-2958.1997.4251782.x","article-title":"Quorum sensing by peptide pheromones and two-component signal-transduction systems in gram-positive bacteria","volume":"24","author":"Kleerebezem","year":"1997","journal-title":"Mol. Microbiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1039\/c5fo01096a","article-title":"Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota","volume":"7","author":"Klinder","year":"2016","journal-title":"Food Funct."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.drudis.2008.07.002","article-title":"Where is the hope for drug discovery? Let history tell the future","volume":"14","author":"Kong","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1128\/aac.02060-13","article-title":"Iron-induced virulence of salmonella enterica serovar typhimurium at the intestinal epithelial interface can be suppressed by carvacrol","volume":"58","author":"Kortman","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.fitote.2015.02.002","article-title":"Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa","volume":"102","author":"Kumar","year":"2015","journal-title":"Fitoterapia"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.2174\/1568026615666150427113937","article-title":"Neocryptolepine: a promising indoloisoquinoline alkaloid with interesting biological activity. Evaluation of the drug and its most relevant analogs","volume":"15","author":"Larghi","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s10068-017-0287-8","article-title":"Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1","volume":"27","author":"Lee","year":"2018","journal-title":"Food Sci. 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Chem."},{"key":"ref160","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.tim.2016.11.013","article-title":"The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover","volume":"25","author":"Zhou","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref161","doi-asserted-by":"publisher","first-page":"589640","DOI":"10.3389\/fmicb.2020.589640","article-title":"Regulatory mechanisms and promising applications of quorum sensing-inhibiting agents in control of bacterial biofilm formation","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref162","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1002\/bit.25588","article-title":"Building terpene production platforms in yeast","volume":"112","author":"Zhuang","year":"2015","journal-title":"Biotechnol. 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