{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:18Z","timestamp":1753891218592,"version":"3.41.2"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Quorum sensing (QS) is a bacterial cell-cell communication system with genetically regulated mechanisms dependent on cell density. Canonical QS systems in gram-negative bacteria possess an autoinducer synthase (LuxI family) and a transcriptional regulator (LuxR family) that respond to an autoinducer molecule. In Gram-positive bacteria, the LuxR transcriptional regulators <jats:italic>\u201csolo\u201d<\/jats:italic> (not associated with a LuxI homolog) may play key roles in intracellular communication. <jats:italic>Arthrobacter<\/jats:italic> sp. UMCV2 is an actinobacterium that promotes plant growth by emitting the volatile organic compound <jats:italic>N, N<\/jats:italic>-dimethylhexadecylamine (DMHDA). This compound induces iron deficiency, defense responses in plants, and swarming motility in <jats:italic>Arthrobacter<\/jats:italic> sp. UMCV2. In this study, the draft genome of this bacterium was assembled and compared with the genomes of type strains of the <jats:italic>Arthrobacter<\/jats:italic> genus, finding that it does not belong to any previously described species. Genome explorations also revealed the presence of 16 <jats:italic>luxR<\/jats:italic>-related genes, but no <jats:italic>luxI<\/jats:italic> homologs were discovered. Eleven of these sequences possess the LuxR characteristic DNA-binding domain with a helix-turn-helix motif and were designated as auto-inducer-related regulators (AirR). Four sequences possessed LuxR analogous domains and were designated as auto-inducer analogous regulators (AiaR). When swarming motility was induced with DMHDA, eight <jats:italic>airR<\/jats:italic> genes and two <jats:italic>aiaR<\/jats:italic> genes were upregulated. These results indicate that the expression of multiple <jats:italic>luxR<\/jats:italic>-related genes is induced in actinobacteria, such as <jats:italic>Arthrobacter<\/jats:italic> sp. UMCV2, by the action of the bacterial biocompound DMHDA when QS behavior is produced.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1040932","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T05:24:02Z","timestamp":1667193842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative genomic and functional analysis of Arthrobacter sp. 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