{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:30:21Z","timestamp":1793107821150,"version":"4.5.0"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The emergence of antimicrobial resistance among microorganisms is a serious public health concern, and extended-spectrum \u03b2-lactamases (ESBL)-producing<jats:italic>Enterobacterales<\/jats:italic>is one of the major concerns among antibiotic-resistant bacteria. Although the prevalence of ESBL in<jats:italic>Enterobacterales<\/jats:italic>has been increasing with time, the prevalence of ESBL could differ according to the species, hospital allocation, sources of infections, nosocomial or community acquisitions, and geographic regions. Therefore, we conducted a comprehensive review of the epidemiology of ESBL-producing<jats:italic>Enterobacterales<\/jats:italic>in Taiwan. Overall, the rates of ESBL producers are higher in northern regions than in other parts of Taiwan. In addition, the genotypes of ESBL vary according to different<jats:italic>Enterobacterales<\/jats:italic>. SHV-type ESBLs (SHV-5 and SHV-12) were the major types of<jats:italic>Enterobacter cloacae<\/jats:italic>complex, but<jats:italic>Serratia marcescens, Proteus mirabilis, Escherichia coli,<\/jats:italic>and<jats:italic>Klebsiella pneumoniae<\/jats:italic>were more likely to possess CTX-M-type ESBLs (CTX-M-3 and CTX-M-14). Moreover, a clonal sequence type of O25b-ST131 has been emerging among urinary or bloodstream<jats:italic>E. coli<\/jats:italic>isolates in the community in Taiwan, and this clone was potentially associated with virulence, ESBL (CTX-M-15) production, ciprofloxacin resistance, and mortality. Finally, the evolution of the genetic traits of the ESBL-producing<jats:italic>Enterobacterales<\/jats:italic>isolates helps us confirm the interhospital and intrahospital clonal dissemination in several regions of Taiwan. In conclusion, continuous surveillance in the investigation of ESBL production among<jats:italic>Enterobacterales<\/jats:italic>is needed to establish its long-term epidemiology.<\/jats:p>","DOI":"10.3389\/fmicb.2022.1060050","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T13:11:26Z","timestamp":1674738686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiology of extended-spectrum \u03b2-lactamases in Enterobacterales in Taiwan for over two decades"],"prefix":"10.3389","volume":"13","author":[{"given":"Chien-Ming","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0732-8893(99)00106-6","article-title":"In vitro evaluation of cefepime and other broad-spectrum beta-lactams in Taiwan medical centers. 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