{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:55:06Z","timestamp":1789088106960,"version":"build-2803163510"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brucellosis is a neglected zoonotic disease found predominantly in lower- and middle-income countries (LMICs), causing significant public health concern in India. The objective of this study was to assess the prevalence of human brucellosis in Odisha, India among community members involved in animal husbandry as a common practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This cross-sectional study included 817 adult participants from 11 districts in Odisha. Four districts from the Northern division, four districts from the Central division, and three districts from the Southern division were selected for the study. Blood samples were collected during a COVID-19 serosurvey in Odisha conducted from 1st to 17th September 2021. Immunoglobulin-G (IgG) antibodies were measured against\n                      <jats:italic>Brucella<\/jats:italic>\n                      using a commercial ELISA kit. Point estimates at 95% confidence intervals (CIs) and adjusted odds ratio were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall prevalence of anti-Brucella IgG antibodies was calculated at 16.65% (95% CI: 14.19\u201319.42). The highest seropositivity was found in Sambalpur district (29.73%; 95% CI: 16.43\u201347.16) and the lowest was determined in Mayurbhanj district (4.44%; 95% CI: 0.99\u201315.60). Compared to males, females were more prone to contracting the disease (AOR: 1.13; 95% CI: 1.05\u20131.67). Participants from rural settings had higher prevalence of anti-Brucella IgG antibodies than urban dwellers (AOR: 4.53; 95% CI: 1.73\u201311.86).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed that human brucellosis was associated with sociodemographic factors like gender, living settings, and household numbers. To prevent brucellosis, screening should be initiated, infected humans should be treated early, and the public should be educated about risk factors and preventive measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2022.1070276","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T23:47:41Z","timestamp":1669592861000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Seroprevalence of human brucellosis among the tribal and non-tribal population residing in an eastern state of India: Findings from the state-wide serosurvey"],"prefix":"10.3389","volume":"13","author":[{"given":"Debaprasad","family":"Parai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrat Kumar","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matrujyoti","family":"Pattnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparajita","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisha","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopamudra Jena","family":"Samanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmita","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Ram","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanhu Charan","family":"Nahak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Pati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdutta","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"796","DOI":"10.26719\/2000.6.4.796","article-title":"Fifty years of veterinary public health activities in the Eastern Mediterranean Region","volume":"6","author":"Abou","year":"2000","journal-title":"East Mediter Health J."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12879-020-4763-z","article-title":"Sero-prevalence and risk factors of brucellosis among suspected febrile patients attending a referral hospital in southern Saudi Arabia (2014\u20132018)","volume":"20","author":"Alkahtani","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"17367","DOI":"10.1038\/s41598-021-96774-x","article-title":"Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020","author":"An","year":"2021","journal-title":"Sci. Rep."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/j.ijid.2009.06.031","article-title":"Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature","volume":"14","author":"Buzgan","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"ref5","volume-title":"Brucellosis in Humans and Animals","author":"Corbel","year":"2006"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3855\/jidc.1442","article-title":"Acute renal failure due to Brucella melitensis","volume":"5","author":"Dagli","year":"2011","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e1929","DOI":"10.1371\/journal.pntd.0001929","article-title":"Clinical manifestations of human brucellosis: a systematic review and meta-analysis","volume":"6","author":"Dean","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e1865","DOI":"10.1371\/journal.pntd.0001865","article-title":"Global burden of human brucellosis: a systematic review of disease frequency","volume":"6","author":"Dean","year":"2012","journal-title":"PLOS Negl. Trop. D"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5334\/aogh.3474","article-title":"Changing patterns in epidemiology of brucellosis in the south of Iran (2015\u20132020): based on Cochrane-Armitage trend test","volume":"88","author":"Delam","year":"2022","journal-title":"Ann. Glob. Health"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4103\/1995-7645.280224","article-title":"Epidemiological, molecular characterisation and risk factors of human brucellosis in Iran","volume":"13","author":"Etemadi","year":"2020","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-017-5016-y","article-title":"Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action","volume":"18","author":"Franc","year":"2018","journal-title":"BMC Public Health"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.4103\/jfmpc.jfmpc_1153_20","article-title":"Human brucellosis: Seroprevalence and associated exposure factors among the rural population in Nagpur, Maharashtra, India","volume":"10","author":"Ghugey","year":"2021","journal-title":"J. Family Med. Prim. 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J."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1016\/S2214-109X(20)30169-8","article-title":"Brucellosis in patients with pyrexia of unknown origin in Assam, India: a retrospective record review","volume":"8","author":"Jamir","year":"2020","journal-title":"Lancet Glob."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1109\/BigData.2014.7004420","article-title":"Epidemiological modeling of bovine brucellosis in India","volume":"2014","author":"Kang","year":"2014","journal-title":"Proc. IEEE Int. Conf. Big Data"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"749","DOI":"10.34172\/aim.2020.99","article-title":"Seroprevalence of brucellosis among general population in Famenin City, Western Iran in 2016: the Famenin brucellosis cohort study","volume":"23","author":"Keramat","year":"2020","journal-title":"Arch. Iran. Med."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.prevetmed.2017.08.014","article-title":"Association of farmers' socio-economics with bovine brucellosis epidemiology in the dry zone of Sri Lanka","volume":"147","author":"Kothalawala","year":"2017","journal-title":"Prev. Vet. Med."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11250-019-02029-3","article-title":"Brucellosis in India: results of a collaborative workshop to define one health priorities","volume":"52","author":"Lindahl","year":"2020","journal-title":"Trop. Anim. Health Prod."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4103\/0970-0218.158847","article-title":"Serological, clinical, and epidemiological profile of human brucellosis in rural India","volume":"40","author":"Mangalgi","year":"2015","journal-title":"Indian J. Community Med."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/trstmh\/trz133","article-title":"The prevalence and risk factors for human Brucella species infection in a cross-sectional survey of a rural population in Punjab, India","volume":"114","author":"Mangtani","year":"2020","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s12038-008-0072-1","article-title":"Brucellosis in India \u2013 a review","volume":"33","author":"Mantur","year":"2008","journal-title":"J. Biosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.20506\/rst.32.1.2197","article-title":"Economics of brucellosis impact and control in low-income countries","volume":"32","author":"McDermott","year":"2013","journal-title":"Rev. Sci. Tech."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1186\/s12879-021-06654-y","article-title":"Prevalence and risk factors of human brucellosis and malaria among patients with fever in malaria-endemic areas, attending health institutes in Awra and Gulina district, Afar Region, Ethiopia","volume":"21","author":"Mehari","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e0009049","DOI":"10.1371\/journal.pntd.0009049","article-title":"High incidence of human brucellosis in a rural pastoralist community in Kenya, 2015","volume":"15","author":"Munyua","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/ijmr.IJMR_3290_20","article-title":"Prevalence of SARS-CoV-2 infection in India: findings from the national serosurvey, May\u2013June 2020","volume":"152","author":"Murhekar","year":"2020","journal-title":"Indian J. Med. Res."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijid.2017.06.002","article-title":"Epidemiological characteristics of human brucellosis in Hamadan Province during 2009\u20132015: results from the National Notifiable Diseases Surveillance System","volume":"61","author":"Nematollahi","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s40249-020-00715-1","article-title":"Human brucellosis: recent advances and future challenges","volume":"9","author":"O'Callaghan","year":"2020","journal-title":"Infect. Dis. Poverty"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"ref31","first-page":"3255","article-title":"Brucellosis in cattle and occupationally exposed human beings: a serosurvey in Odisha, India","volume":"7","author":"Priyadarshini","year":"2013","journal-title":"J. Pure Appl. Microbiol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/tbed.12804","article-title":"Risk factors for occupational Brucella infection in veterinary personnel in India","volume":"65","author":"Proch","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1089\/fpd.2011.1029","article-title":"Seroprevalence and risk factors for brucellosis in a high-risk group of individuals in Bangladesh","volume":"9","author":"Rahman","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1080\/20477724.2017.1345366","article-title":"Prevalence and risk factors of brucellosis among veterinary health care professionals","volume":"111","author":"Shome","year":"2017","journal-title":"Pathog. Glob. Health"},{"key":"ref35","year":"2022"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"114","DOI":"10.46234\/ccdcw2021.030","article-title":"Epidemiological characteristics of human brucellosis \u2013 China, 2016\u20132019","volume":"3","author":"Tao","year":"2021","journal-title":"China CDC Wkly."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1186\/s12889-015-2242-z","article-title":"Human brucellosis: sero-prevalence and associated risk factors in agro-pastoral communities of Kiboga District, Central Uganda","volume":"15","author":"Tumwine","year":"2015","journal-title":"BMC Public Health"},{"key":"ref38","volume-title":"Seven Neglected Endemic Zoonoses-Some Basic Facts","year":"2011"},{"key":"ref39","year":"2020"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e10113","DOI":"10.7717\/peerj.10113","article-title":"Spatiotemporal expansion of human brucellosis in Shaanxi Province, Northwestern China and model for risk prediction","volume":"8","author":"Yang","year":"2020","journal-title":"PeerJ."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.3402\/ehtj.v4i0.7361","article-title":"Seroepidemiological survey of human brucellosis in and around Ludhiana, India","volume":"28","author":"Yohannes","year":"2011","journal-title":"Emerg Health Threats J."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1016\/j.ijid.2012.12.030","article-title":"Human brucellosis in the People\u2019s republic of China during 2005\u20132010","volume":"17","author":"Zhong","year":"2013","journal-title":"Int. J. Infect. Dis."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.1070276\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T23:47:45Z","timestamp":1669592865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.1070276\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":42,"alternative-id":["10.3389\/fmicb.2022.1070276"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2022.1070276","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]},"article-number":"1070276"}}