{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:19:56Z","timestamp":1787026796877,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QC178"],"award-info":[{"award-number":["ZR2021QC178"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The delivery system of antibiotics plays an important role in increasing the drug efficacy and reducing the risks of off-target toxicities and antibiotic resistance. The pathophysiology of bacterial infections is similar to that of tumor tissues, but only a few delivery systems have been able to target and release antibiotics on demand. Herein, we designed and developed a robust Chitosan-SS-Levofloxacin (CS-SS-LF) micelles for targeted antibiotic delivery, in which disulfide bond can be reduced by hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), a typical product of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , and subsequently released antibiotic to eradicate\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection. CS-SS-LF micelles showed uniform size and sharp response to H\n                    <jats:sub>2<\/jats:sub>\n                    S. Compared with levofloxacin alone, these micelles possessed a better capacity in disrupting\n                    <jats:italic>Salmonella<\/jats:italic>\n                    biofilms and reducing bacterial burden in organs. The H2S-sensitive CS-SS-LF micelles might enable a new way to address bacterial infections.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2022.1088153","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T03:18:15Z","timestamp":1671679095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Hydrogen sulfide-sensitive Chitosan-SS-Levofloxacin micelles with a high drug content: Facile synthesis and targeted Salmonella infection therapy"],"prefix":"10.3389","volume":"13","author":[{"given":"Chunbo","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1080\/17425247.2016.1178719","article-title":"Stimuli-responsive polymers for antimicrobial therapy: drug targeting, contact-killing surfaces and competitive release","volume":"13","author":"Alvarez-Lorenzo","year":"2016","journal-title":"Expert Opin. 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