{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:01:44Z","timestamp":1791583304864,"version":"4.3.4"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312045\/2020-4"],"award-info":[{"award-number":["312045\/2020-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"publisher","award":["serra-1708-15285"],"award-info":[{"award-number":["serra-1708-15285"]}],"id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Intestinal mucositis promoted by the use of anticancer drugs is characterized by ulcerative inflammation of the intestinal mucosa, a debilitating side effect in cancer patients undergoing treatment. Probiotics are a potential therapeutic option to alleviate intestinal mucositis due to their effects on epithelial barrier integrity and anti-inflammatory modulation. This study investigated the health-promoting impact of <jats:italic>Lactobacillus delbrueckii<\/jats:italic> CIDCA 133 in modulating inflammatory and epithelial barrier markers to protect the intestinal mucosa from 5-fluorouracil-induced epithelial damage. <jats:italic>L. delbrueckii<\/jats:italic> CIDCA 133 consumption ameliorated small intestine shortening, inflammatory cell infiltration, intestinal permeability, villus atrophy, and goblet cell count, improving the intestinal mucosa architecture and its function in treated mice. Upregulation of <jats:italic>Muc2<\/jats:italic>, <jats:italic>Cldn1<\/jats:italic>, <jats:italic>Hp<\/jats:italic>, <jats:italic>F11r<\/jats:italic>, and <jats:italic>Il10<\/jats:italic>, and downregulation of markers involved in NF-\u03baB signaling pathway activation (<jats:italic>Tlr2, Tlr4, Nfkb1, Il6<\/jats:italic>, and <jats:italic>Il1b<\/jats:italic>) were observed at the mRNA level. This work suggests a beneficial role of <jats:italic>L. delbrueckii<\/jats:italic> strain CIDCA 133 on intestinal damage induced by 5-FU chemotherapy through modulation of inflammatory pathways and improvement of epithelial barrier function.<\/jats:p>","DOI":"10.3389\/fmicb.2022.858036","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:49:00Z","timestamp":1650966540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Lactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2\/4\/Myd88\/NF-\u03baB Signaling Pathway"],"prefix":"10.3389","volume":"13","author":[{"given":"Fernanda Alvarenga Lima","family":"Barroso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Cl\u00e1udio Lima","family":"de Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tales Fernando","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Lima","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Laguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Dias","family":"Coelho-Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Duarte","family":"Vital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Od\u00edlia Antunes","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valbert Nascimento","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enio","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaviano Santos","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Martins","family":"Drumond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Mancha-Agresti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Birbrair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debmalya","family":"Barh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"fnx102","DOI":"10.1093\/femsle\/fnx102","article-title":"Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088.","volume":"364","author":"Aiba","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.clnu.2015.01.012","article-title":"The role of immunomodulators on intestinal barrier homeostasis in experimental models.","volume":"34","author":"Andrade","year":"2015","journal-title":"Clin. Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1177\/0148607114567508","article-title":"Pretreatment with L-Citrulline positively affects the mucosal architecture and permeability of the small intestine in a murine mucositis model.","volume":"40","author":"Antunes","year":"2016","journal-title":"J. Parenter. Enter. Nutr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/microorganisms9010107","article-title":"Intake of Lactobacillus delbrueckii (pExu:hsp65) prevents the inflammation and the disorganization of the intestinal mucosa in a mouse model of mucositis.","volume":"9","author":"Barroso","year":"2021","journal-title":"Microorganisms"},{"key":"B5","doi-asserted-by":"publisher","first-page":"544490","DOI":"10.3389\/fmicb.2020.544490","article-title":"Probiotics, Prebiotics, synbiotics, and paraprobiotics as a therapeutic alternative for intestinal mucositis.","volume":"11","author":"Batista","year":"2020","journal-title":"Front. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e31808","DOI":"10.1371\/journal.pone.0031808","article-title":"5-Fluorouracil induced intestinal mucositis via nuclear factor-\u03baB activation by transcriptomic analysis and in vivo bioluminescence imaging.","volume":"7","author":"Chang","year":"2012","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/ijms21020386","article-title":"Fecal microbiota transplantation prevents intestinal injury, upregulation of toll-like receptors, and 5-Fluorouracil\/Oxaliplatin-induced toxicity in colorectal cancer.","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3389\/fmicb.2018.00983","article-title":"Lactobacillus casei variety rhamnosus probiotic preventively attenuates 5-fluorouracil\/oxaliplatin-induced intestinal injury in a syngeneic colorectal cancer model.","volume":"9","author":"Chang","year":"2018","journal-title":"Front. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09817-0","article-title":"Antarctic strain of Rhodotorula mucilaginosa UFMGCB 18,377 attenuates mucositis induced by 5-fluorouracil in Mice.","author":"Coutinho","year":"2021","journal-title":"Probiotics Antimicrob. Proteins."},{"key":"B10","doi-asserted-by":"publisher","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body.","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-323-44227-5.00001-6","article-title":"Principles of cancer treatment","author":"Crombie","year":"2016","journal-title":"Clinical Cardio-Oncology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.biopha.2018.04.133","article-title":"Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.","volume":"103","author":"de Barros","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1128\/IAI.01374-15","article-title":"Intestinal epithelial toll-like receptor 4 signaling affects epithelial function and colonic microbiota and promotes a risk for transmissible colitis.","volume":"84","author":"Dheer","year":"2016","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09826-z","article-title":"Safety evaluation of Lactobacillus delbrueckii subsp. lactis CIDCA 133: a health-promoting bacteria.","author":"de Jesus","year":"","journal-title":"Probiotics Antimicrob. Proteins."},{"key":"B15","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3390\/microorganisms9040829","article-title":"Probiogenomics of Lactobacillus delbrueckii subsp. lactis CIDCA 133: in silico, in vitro, and in vivo approaches.","volume":"9","author":"de Jesus","year":"","journal-title":"Microorganisms"},{"key":"B16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jff.2018.12.027","article-title":"Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 fluorouracil-induced intestinal mucositis.","volume":"53","author":"de Jesus","year":"2019","journal-title":"J. Funct. Foods"},{"key":"B17","doi-asserted-by":"publisher","first-page":"S129","DOI":"10.1093\/cid\/civ085","article-title":"Risk and safety of probiotics.","volume":"60","author":"Doron","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jff.2018.09.012","article-title":"Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice.","volume":"49","author":"Galdino","year":"2018","journal-title":"J. Funct. Foods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"501361","DOI":"10.1155\/2015\/501361","article-title":"Interactions between innate immunity, microbiota, and probiotics.","volume":"2015","author":"Giorgetti","year":"2015","journal-title":"J. Immunol. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1006\/meth.2001.1261","article-title":"An Overview of real-time quantitative PCR: applications to quantify cytokine gene expression.","volume":"25","author":"Giulietti","year":"2001","journal-title":"Methods"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1039\/C5FO01396H","article-title":"Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats.","volume":"7","author":"Hsieh","year":"2016","journal-title":"Food Funct."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.3168\/jds.2019-17836","article-title":"Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil.","volume":"103","author":"Hu","year":"2020","journal-title":"J. Dairy Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/j.1472-765X.2008.02363.x","article-title":"Lactobacilli antagonize biological effects of enterohaemorrhagic Escherichia coli in vitro.","volume":"46","author":"Hugo","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11274-017-2219-4","article-title":"Lactobacillus delbrueckii subsp. lactis (strain CIDCA 133) stimulates murine macrophages infected with Citrobacter rodentium.","volume":"33","author":"Hugo","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"103994","DOI":"10.1016\/j.jff.2020.103994","article-title":"Live and heat-killed cells of Lactobacillus plantarum Zhang-LL ease symptoms of chronic ulcerative colitis induced by dextran sulfate sodium in rats.","volume":"71","author":"Jin","year":"2020","journal-title":"J. Funct. Foods"},{"key":"B26","doi-asserted-by":"publisher","first-page":"154791","DOI":"10.1016\/j.cyto.2019.154791","article-title":"Modulation of 5-fluorouracil activation of toll-like\/MyD88\/NF-\u03baB\/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic.","volume":"125","author":"Justino","year":"2020","journal-title":"Cytokine"},{"key":"B27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00280-014-2663-x","article-title":"Regulatory role of Lactobacillus acidophilus on inflammation and gastric dysmotility in intestinal mucositis induced by 5-fluorouracil in mice.","volume":"75","author":"Justino","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"G851","DOI":"10.1152\/ajpgi.00327.2009","article-title":"Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.","volume":"298","author":"Karczewski","year":"2010","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/1440-1681.12792","article-title":"Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses.","volume":"44","author":"Kato","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-\u03baB by toll-like receptors.","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.3892\/ol.2018.8893","article-title":"Ursodeoxycholic acid attenuates 5-fluorouracil-induced mucositis in a rat model.","volume":"16","author":"Kim","year":"2018","journal-title":"Oncol. Lett."},{"key":"B32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2174\/1573401311309020004","article-title":"Protection and restitution of gut barrier by probiotics: nutritional and clinical implications.","volume":"9","author":"Krishna Rao","year":"2013","journal-title":"Curr. Nutr. Food Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"905","DOI":"10.4315\/0362-028X-62.8.905","article-title":"Screening of bile resistance and bile precipitation in lactic acid bacteria and bifidobacteria.","volume":"62","author":"Kociubinski","year":"1999","journal-title":"J. Food Prot."},{"key":"B34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fcimb.2017.00455","article-title":"Alteration of gut microbiota and inflammatory cytokine\/chemokine profiles in 5-fluorouracil induced intestinal mucositis.","volume":"7","author":"Li","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12934-020-1289-4","article-title":"Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier.","volume":"19","author":"Liu","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"B36","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-Fluorouracil: mechanisms of action and clinical strategies.","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B37","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1477-5751-13-6","article-title":"Pretreatment with Saccharomyces boulardii does not prevent the experimental mucositis in Swiss mice.","volume":"13","author":"Maioli","year":"2014","journal-title":"J. Negat. Results Biomed."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/cancers2031717","article-title":"5-FU Metabolism in cancer and orally-administrable 5-FU Drugs.","volume":"2","author":"Miura","year":"2010","journal-title":"Cancers (Basel)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bjid.2015.10.011","article-title":"TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review.","volume":"20","author":"Mukherjee","year":"2016","journal-title":"Braz. J. Infect. Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/1547691X.2021.1979698","article-title":"Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: high-dose and long-term use effects on immune-related safety and intestinal bacterial flora.","volume":"18","author":"Nakai","year":"2021","journal-title":"J. Immunotoxicol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"120445","DOI":"10.1016\/j.lfs.2022.120445","article-title":"Paraprobiotic Enterococcus faecalis EC-12 prevents the development of irinotecan-induced intestinal mucositis in mice.","volume":"296","author":"Nobre","year":"2022","journal-title":"Life Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0192021","DOI":"10.1371\/journal.pone.0192021","article-title":"Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces.","volume":"13","author":"Oh","year":"2018","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1073\/pnas.0910307107","article-title":"Probiotics promote gut health through stimulation of epithelial innate immunity.","volume":"107","author":"Pagnini","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B44","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1093\/advances\/nmy063","article-title":"Mechanisms of action of probiotics.","volume":"10","author":"Plaza-Diaz","year":"2019","journal-title":"Adv. Nutr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1053\/j.gastro.2009.03.007","article-title":"Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.","volume":"137","author":"Podolsky","year":"2009","journal-title":"Gastroenterology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00280-019-03865-8","article-title":"Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in mice.","volume":"84","author":"Porto","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1080\/10408390903551747","article-title":"Evidence supporting the use of probiotics for the prevention and treatment of chemotherapy-induced intestinal mucositis.","volume":"51","author":"Prisciandaro","year":"","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"671","DOI":"10.4161\/cbt.11.7.14896","article-title":"Probiotic factors partially improve parameters of 5-fluorouracil-induced intestinal mucositis in rats.","volume":"11","author":"Prisciandaro","year":"","journal-title":"Cancer Biol. Ther."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1080\/01635581.2019.1675719","article-title":"Probiotic mixture containing Lactobacillus spp. and Bifidobacterium spp. attenuates 5-fluorouracil-induced intestinal mucositis in mice.","volume":"72","author":"Quaresma","year":"2020","journal-title":"Nutr. Cancer"},{"key":"B50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/09540105.2019.1579785","article-title":"Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1.","volume":"30","author":"Ren","year":"2019","journal-title":"Food Agric. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3920\/BM2015.0191","article-title":"Lactobacillus delbrueckii subsp lactis CIDCA 133 modulates response of human epithelial and dendritic cells infected with Bacillus cereus.","volume":"7","author":"Rolny","year":"2016","journal-title":"Benef. Microbes"},{"key":"B52","doi-asserted-by":"publisher","first-page":"6729","DOI":"10.3390\/ijms22136729","article-title":"Probiotics, prebiotics and epithelial tight junctions: a promising approach to modulate intestinal barrier function.","volume":"22","author":"Rose","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00280-008-0715-9","article-title":"Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution.","volume":"63","author":"Soares","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"322","DOI":"10.15430\/JCP.2013.18.4.322","article-title":"5-fluorouracil-induced changes of intestinal integrity biomarkers in BALB\/C mice.","volume":"18","author":"Song","year":"2013","journal-title":"J. Cancer Prev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis.","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"B56","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3181\/0810-RM-301","article-title":"Gastrointestinal microflora and mucins may play a critical role in the development of 5-fluorouracil-induced gastrointestinal mucositis.","volume":"234","author":"Stringer","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.nut.2016.05.003","article-title":"Administration of probiotic mixture DM#1 ameliorated 5-fluorouracil\u2013induced intestinal mucositis and dysbiosis in rats.","volume":"33","author":"Tang","year":"2017","journal-title":"Nutrition"},{"key":"B58","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3920\/BM2017.0082","article-title":"Oral administration of Simbioflora\u00ae (synbiotic) attenuates intestinal damage in a mouse model of 5-fluorouracil-induced mucositis.","volume":"9","author":"Trindade","year":"2018","journal-title":"Benef. Microbes"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09842-z","article-title":"Paraprobiotic Lacticaseibacillus rhamnosus protects intestinal damage in an experimental murine model of mucositis.","author":"Trindade","year":"2021","journal-title":"Probiotics Antimicrob. Proteins."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e1000879","DOI":"10.1371\/journal.ppat.1000879","article-title":"The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis.","volume":"6","author":"van Vliet","year":"2010","journal-title":"PLoS Pathog."},{"key":"B61","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jnutbio.2011.01.007","article-title":"Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis.","volume":"23","author":"Vieira","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e1208468","DOI":"10.1080\/21688370.2016.1208468","article-title":"Intestinal barrier analysis by assessment of mucins, tight junctions, and \u03b1-defensins in healthy C57BL\/6J and BALB\/cJ mice.","volume":"4","author":"Volynets","year":"2016","journal-title":"Tissue Barriers"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3389\/fmicb.2018.01953","article-title":"Probiotic Lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota.","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"9321196","DOI":"10.1155\/2021\/9321196","article-title":"Administration of a probiotic mixture ameliorates cisplatin-induced mucositis and pica by regulating 5-HT in rats.","volume":"2021","author":"Wu","year":"2021","journal-title":"J. Immunol. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e0138746","DOI":"10.1371\/journal.pone.0138746","article-title":"Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model.","volume":"10","author":"Yeung","year":"2015","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"251","DOI":"10.21307\/pjm-2018-044","article-title":"Are probiotic really safe for humans?","volume":"67","author":"Zawistowska-Rojek","year":"2018","journal-title":"Polish J. Microbiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3748\/wjg.v23.i7.1180","article-title":"Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-\u03baB activation.","volume":"23","author":"Zheng","year":"2017","journal-title":"World J. Gastroenterol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.858036\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:49:04Z","timestamp":1650966544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.858036\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":67,"alternative-id":["10.3389\/fmicb.2022.858036"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2022.858036","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"article-number":"858036"}}