{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:55:15Z","timestamp":1792533315280,"version":"4.5.0"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012438","name":"Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>MicroRNAs (miRNAs) are small non-coding RNA that affect mRNA abundance or translation efficiency by binding to the 3\u2032UTR of the mRNA of the target gene, thereby participating in multiple biological processes, including viral infection. <jats:italic>Flavivirus<\/jats:italic> genus consists of small, positive-stranded, single-stranded RNA viruses transmitted by arthropods, especially mosquitoes and ticks. The genus contains several globally significant human\/animal pathogens, such as Dengue virus, Japanese encephalitis virus, West Nile virus, Zika virus, Yellow fever virus, Tick-borne encephalitis virus, and Tembusu virus. After flavivirus invades, the expression of host miRNA changes, exerting the immune escape mechanism to create an environment conducive to its survival, and the altered miRNA in turn affects the life cycle of the virus. Accumulated evidence suggests that host miRNAs influence flavivirus replication and host\u2013virus interactions through direct binding of viral genomes or through virus-mediated host transcriptome changes. Furthermore, miRNA can also interweave with other non-coding RNAs, such as long non-coding RNA and circular RNA, to form an interaction network to regulate viral replication. A variety of non-coding RNAs produced by the virus itself exert similar function by interacting with cellular RNA and viral RNA. Understanding the interaction sites between non-coding RNA, especially miRNA, and virus\/host genes will help us to find targets for antiviral drugs and viral therapy.<\/jats:p>","DOI":"10.3389\/fmicb.2022.869441","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T08:08:45Z","timestamp":1649664525000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Regulatory Role of Host MicroRNAs in Flaviviruses Infection"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenjun","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009425","article-title":"Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus.","volume":"15","author":"Alpuche-Lazcano","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.meegid.2018.12.033","article-title":"Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: implications for the cytokine response.","volume":"69","author":"Arboleda","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1128\/JVI.02586-15","article-title":"MicroRNA-19b-3p Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF11.","volume":"90","author":"Ashraf","year":"2016","journal-title":"J. Virol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1099\/jgv.0.001441","article-title":"Del \u00c1ngel RM, et al. miR-927 has pro-viral effects during acute and persistent infection with dengue virus type 2 in C6\/36 mosquito cells.","volume":"101","author":"Avila-Bonilla","year":"2020","journal-title":"J. Gen. Virol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2021.1909902","article-title":"Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus.","volume":"16","author":"Bagasra","year":"2021","journal-title":"Libyan J. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1021\/acs.chemrev.7b00719","article-title":"Biochemistry and Molecular Biology of Flaviviruses.","volume":"118","author":"Barrows","year":"2018","journal-title":"Chem. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function.","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/s41418-018-0163-y","article-title":"Zika virus E protein alters the properties of human fetal neural stem cells by modulating microRNA circuitry.","volume":"25","author":"Bhagat","year":"2018","journal-title":"Cell Death Differ."},{"key":"B9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainresbull.2021.08.009","article-title":"Zika virus E protein dysregulate mir-204\/WNT2 signalling in human fetal neural stem cells.","volume":"176","author":"Bhagat","year":"2021","journal-title":"Brain Res. Bull."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6290","DOI":"10.1007\/s12035-021-02548-x","article-title":"Zika Virus NS1 Suppresses VE-Cadherin and Claudin-5 via hsa-miR-101-3p in Human Brain Microvascular Endothelial Cells.","volume":"58","author":"Bhardwaj","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1073\/pnas.1810771116","article-title":"Engineered resistance to Zika virus in transgenic expressing a polycistronic cluster of synthetic small RNAs.","volume":"116","author":"Buchman","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/imb.12070","article-title":"MicroRNA levels are modulated in Aedes aegypti after exposure to Dengue-2.","volume":"23","author":"Campbell","year":"2014","journal-title":"Insect Mol. Biol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1364-y","article-title":"Complex interaction between dengue virus replication and expression of miRNA-133a.","volume":"16","author":"Castillo","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1590\/0074-02760160404","article-title":"Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication.","volume":"112","author":"Castrill\u00f3n-Betancur","year":"2017","journal-title":"Mem. Inst. Oswaldo. Cruz."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/1759091419850983","article-title":"MicroRNAs 145 and 148a Are Upregulated During Congenital Zika Virus Infection.","volume":"11","author":"Castro","year":"2019","journal-title":"ASN Neuro."},{"key":"B16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbi.2021.01.012","article-title":"DHA attenuated Japanese Encephalitis virus infection-induced neuroinflammation and neuronal cell death in cultured rat Neuron\/glia.","volume":"93","author":"Chang","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jinf.2014.05.013","article-title":"Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever.","volume":"69","author":"Chen","year":"2014","journal-title":"J. Infect."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3722","DOI":"10.1128\/JVI.03242-15","article-title":"MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1.","volume":"90","author":"Chen","year":"2016","journal-title":"J. Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models.","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00596","article-title":"Duck Tembusu Virus Utilizes miR-221-3p Expression to Facilitate Viral Replication Targeting of Suppressor of Cytokine Signaling 5.","volume":"11","author":"Cui","year":"2020","journal-title":"Front. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.meegid.2018.05.020","article-title":"Analysis of the microRNA expression profiles in DEF cells infected with duck Tembusu virus.","volume":"63","author":"Cui","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1016\/j.celrep.2019.05.059","article-title":"Genome-wide Integrative Analysis of Zika-Virus-Infected Neuronal Stem Cells Reveals Roles for MicroRNAs in Cell Cycle and Stemness.","volume":"27","author":"Dang","year":"2019","journal-title":"Cell Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.coi.2018.06.010","article-title":"Antiviral RNA interference in mammals.","volume":"54","author":"Ding","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005981","article-title":"MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression.","volume":"11","author":"Diosa-Toro","year":"2017","journal-title":"PLoS Negl. Trop Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.virusres.2014.11.010","article-title":"Let-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells.","volume":"196","author":"Escalera-Cueto","year":"2015","journal-title":"Virus Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-virology-101416-041848","article-title":"The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis.","volume":"5","author":"Glasner","year":"2018","journal-title":"Annu. Rev. Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"19136","DOI":"10.1073\/pnas.1905617116","article-title":"Subgenomic flavivirus RNA binds the mosquito DEAD\/H-box helicase ME31B and determines Zika virus transmission by.","volume":"116","author":"G\u00f6ertz","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.4049\/jimmunol.1900003","article-title":"miR-301a Regulates Inflammatory Response to Japanese Encephalitis Virus Infection via Suppression of NKRF Activity.","volume":"203","author":"Hazra","year":"2019","journal-title":"J. Immunol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf5185","article-title":"The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection.","volume":"10","author":"Hazra","year":"2017","journal-title":"Sci. Signal."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1128\/JVI.02091-10","article-title":"Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.","volume":"85","author":"Heiss","year":"2011","journal-title":"J. Virol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1128\/JVI.07125-11","article-title":"MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.","volume":"86","author":"Heiss","year":"2012","journal-title":"J. Virol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49572-5","article-title":"Ixodes scapularis salivary gland microRNAs are differentially expressed during Powassan virus transmission.","volume":"9","author":"Hermance","year":"2019","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084218","article-title":"Differential miRNA Expression Profiling Reveals Correlation of miR125b-5p with Persistent Infection of Japanese Encephalitis Virus.","volume":"22","author":"Huang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104392","article-title":"Duck Tembusu virus promotes the expression of suppressor of cytokine signaling 1 by downregulating miR-148a-5p to facilitate virus replication.","volume":"85","author":"Huang","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1073\/pnas.1320123111","article-title":"MicroRNA-like viral small RNA from Dengue virus 2 autoregulates its replication in mosquito cells.","volume":"111","author":"Hussain","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1093\/nar\/gkr848","article-title":"West Nile virus encodes a microRNA-like small RNA in the 3\u2019 untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells.","volume":"40","author":"Hussain","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ibmb.2012.11.005","article-title":"Blood meal induced microRNA regulates development and immune associated genes in the Dengue mosquito vector. Aedes aegypti.","volume":"43","author":"Hussain","year":"2013","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1499-z","article-title":"Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments.","volume":"10","author":"Iannolo","year":"2019","journal-title":"Cell Death Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e294","DOI":"10.1128\/JVI.00294-20","article-title":"Degradation of MicroRNA miR-466d-3p by Japanese Encephalitis Virus NS3 Facilitates Viral Replication and Interleukin-1\u03b2 Expression.","volume":"94","author":"Jiang","year":"2020","journal-title":"J. Virol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1172\/jci58849","article-title":"MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-\u03baB\/I\u03baB\u03b1 negative feedback loop.","volume":"122","author":"Jiang","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.","volume":"309","author":"Jopling","year":"2005","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.antiviral.2017.03.020","article-title":"miR-21 promotes dengue virus serotype 2 replication in HepG2 cells.","volume":"142","author":"Kanokudom","year":"2017","journal-title":"Antiviral Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1057","DOI":"10.1128\/JVI.01057-18","article-title":"MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2.","volume":"92","author":"Kumar","year":"2018","journal-title":"J. Virol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.virol.2014.01.004","article-title":"Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus.","volume":"45","author":"Kumar","year":"2014","journal-title":"Virology"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/srep20263","article-title":"Dynamic changes in global microRNAome and transcriptome reveal complex miRNA-mRNA regulated host response to Japanese Encephalitis Virus in microglial cells.","volume":"6","author":"Kumari","year":"2016","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165677","article-title":"The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle.","volume":"21","author":"Kunden","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation.","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.bbrc.2010.04.080","article-title":"Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon.","volume":"396","author":"Lee","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stem.2016.04.017","article-title":"Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.stem.2016.08.005","article-title":"Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation.","volume":"19","author":"Li","year":"2016","journal-title":"Cell Stem Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.2147\/NDT.S113236","article-title":"miR-370 mimic inhibits replication of Japanese encephalitis virus in glioblastoma cells.","volume":"12","author":"Li","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-020-06822-5","article-title":"Genome-wide profiling of host-encoded circular RNAs highlights their potential role during the Japanese encephalitis virus-induced neuroinflammatory response.","volume":"21","author":"Li","year":"2020","journal-title":"BMC Genom."},{"key":"B53","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.antiviral.2018.12.016","article-title":"Dengue drug discovery: progress, challenges and outlook.","volume":"163","author":"Lim","year":"2019","journal-title":"Antiviral Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biotechadv.2017.09.004","article-title":"Zika virus structural biology and progress in vaccine development.","volume":"36","author":"Lin","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"B55","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/cmi.2015.52","article-title":"Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection.","volume":"13","author":"Liu","year":"2016","journal-title":"Cell Mol. Immunol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2017.1304505","article-title":"Computational identification of mutually homologous Zika virus miRNAs that target microcephaly genes.","volume":"12","author":"McLean","year":"2017","journal-title":"Libyan. J. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes.","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.4049\/jimmunol.2000411","article-title":"Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells.","volume":"205","author":"Mishra","year":"2020","journal-title":"J. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly.","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/jnc.14645","article-title":"Japanese Encephalitis Virus-induced let-7a\/b interacted with the NOTCH-TLR7 pathway in microglia and facilitated neuronal death via caspase activation.","volume":"149","author":"Mukherjee","year":"2019","journal-title":"J. Neurochem."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00024","article-title":"The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection.","volume":"11","author":"Murphy Schafer","year":"2020","journal-title":"Front. Microbiol."},{"key":"B62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/CMR.00072-15","article-title":"Zika Virus.","volume":"29","author":"Musso","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/v12010009","article-title":"Cellular microRNA-155 Regulates Virus-Induced Inflammatory Response and Protects against Lethal West Nile Virus Infection.","volume":"12","author":"Natekar","year":"2019","journal-title":"Viruses"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-97","article-title":"MiR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses.","volume":"11","author":"Pareek","year":"2014","journal-title":"J. Neuroinflam."},{"key":"B65","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrg3162","article-title":"MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.","volume":"13","author":"Pasquinelli","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"5322","DOI":"10.1016\/j.jmb.2020.07.015","article-title":"Uncovering the Roles of miR-214 in Hepatitis E Virus Replication.","volume":"432","author":"Patil","year":"2020","journal-title":"J. Mol. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1001\/jama.2013.8042","article-title":"West Nile virus: review of the literature.","volume":"310","author":"Petersen","year":"2013","journal-title":"JAMA"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002465","article-title":"Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination.","volume":"8","author":"Pham","year":"2012","journal-title":"PLoS Pathog."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/v13101992","article-title":"ZIKV Infection and miRNA Network in Pathogenesis and Immune Response.","volume":"13","author":"Polonio","year":"2021","journal-title":"Viruses"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006535","article-title":"Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission.","volume":"13","author":"Pompon","year":"2017","journal-title":"PLoS Pathog."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.freeradbiomed.2011.09.014","article-title":"Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells.","volume":"51","author":"Pulkkinen","year":"2011","journal-title":"Free Radic Biol. Med."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00291","article-title":"Modulation of Type-I Interferon Response by hsa-miR-374b-5p During Japanese Encephalitis Virus Infection in Human Microglial Cells.","volume":"9","author":"Rastogi","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005760","article-title":"Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes.","volume":"11","author":"Salda\u00f1a","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"13486","DOI":"10.1128\/JVI.01104-12","article-title":"Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells.","volume":"86","author":"Schnettler","year":"2012","journal-title":"J. Virol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"5708","DOI":"10.1128\/JVI.00207-12","article-title":"West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response.","volume":"86","author":"Schuessler","year":"2012","journal-title":"J. Virol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1080\/22221751.2020.1821581","article-title":"mRNA and miRNA profiling of Zika virus-infected human umbilical cord mesenchymal stem cells identifies miR-142-5p as an antiviral factor.","volume":"9","author":"Seong","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1242\/dev.143768","article-title":"Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage.","volume":"143","author":"Shao","year":"2016","journal-title":"Development"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/srep27685","article-title":"Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5.","volume":"6","author":"Sharma","year":"2016","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0249-0","article-title":"miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells.","volume":"12","author":"Sharma","year":"2015","journal-title":"J. Neuroinflam."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.ijbiomac.2021.11.061","article-title":"Zika virus NS1 suppresses the innate immune responses via miR-146a in human microglial cells.","volume":"193","author":"Shukla","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-119","article-title":"Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus.","volume":"11","author":"Skalsky","year":"2010","journal-title":"BMC Genom."},{"key":"B83","doi-asserted-by":"publisher","first-page":"8457","DOI":"10.1128\/JVI.00317-14","article-title":"Expression of mosquito microRNA Aae-miR-2940-5p is downregulated in response to West Nile virus infection to restrict viral replication.","volume":"88","author":"Slonchak","year":"2014","journal-title":"J. Virol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.antiviral.2018.09.006","article-title":"Subgenomic flaviviral RNAs: What do we know after the first decade of research.","volume":"159","author":"Slonchak","year":"2018","journal-title":"Antiviral Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1128\/JVI.02608-15","article-title":"Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication.","volume":"90","author":"Slonchak","year":"2015","journal-title":"J. Virol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1128\/JVI.06883-11","article-title":"Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors.","volume":"86","author":"Smith","year":"2012","journal-title":"J. Virol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"e2388","DOI":"10.1128\/JVI.02388-16","article-title":"A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection.","volume":"91","author":"Smith","year":"2017","journal-title":"J. Virol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e1700","DOI":"10.1128\/JVI.01700-20","article-title":"Swine MicroRNAs and Restrict the Cross-Species Infection of Avian Influenza Virus.","volume":"94","author":"Song","year":"2020","journal-title":"J. Virol."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-1966-2","article-title":"Identification of microRNAs expressed in the midgut of Aedes albopictus during dengue infection.","volume":"10","author":"Su","year":"2017","journal-title":"Parasit. Vectors"},{"key":"B90","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.1096\/fj.201902878R","article-title":"MicroRNA-155 inhibits dengue virus replication by inducing heme oxygenase-1-mediated antiviral interferon responses.","volume":"34","author":"Su","year":"2020","journal-title":"FASEB J."},{"key":"B91","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/jnc.12609","article-title":"MicroRNA-29b modulates Japanese encephalitis virus-induced microglia activation by targeting tumor necrosis factor alpha-induced protein 3.","volume":"129","author":"Thounaojam","year":"","journal-title":"J. Neurochem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"4798","DOI":"10.1128\/JVI.02979-13","article-title":"MicroRNA 155 regulates Japanese encephalitis virus-induced inflammatory response by targeting Src homology 2-containing inositol phosphatase 1.","volume":"88","author":"Thounaojam","year":"","journal-title":"J. Virol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.molmed.2016.11.003","article-title":"MicroRNA Regulation of RNA Virus Replication and Pathogenesis.","volume":"23","author":"Trobaugh","year":"2017","journal-title":"Trends Mol. Med."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/srep33088","article-title":"Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host.","volume":"6","author":"Tsetsarkin","year":"2016","journal-title":"Sci. Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.jinf.2014.12.001","article-title":"Cellular microRNA-miR-548g-3p modulates the replication of dengue virus.","volume":"70","author":"Wen","year":"2015","journal-title":"J. Infect."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0614-x","article-title":"Role of microRNAs in antiviral responses to dengue infection.","volume":"27","author":"Wong","year":"2020","journal-title":"J. Biomed Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.micinf.2014.08.011","article-title":"miR-223 inhibits dengue virus replication by negatively regulating the microtubule-destabilizing protein STMN1 in EAhy926 cells.","volume":"16","author":"Wu","year":"2014","journal-title":"Microb. Infect."},{"key":"B98","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jinf.2013.05.003","article-title":"miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6.","volume":"67","author":"Wu","year":"2013","journal-title":"J. Infect."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009633","article-title":"Identification of potential biomarkers in dengue via integrated bioinformatic analysis.","volume":"15","author":"Xie","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B100","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1080\/21505594.2020.1735051","article-title":"MiR-140 inhibits classical swine fever virus replication by targeting Rab25 in swine umbilical vein endothelial cells.","volume":"11","author":"Xu","year":"2020","journal-title":"Virulence"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/jmv.23815","article-title":"miR-252 of the Asian tiger mosquito Aedes albopictus regulates dengue virus replication by suppressing the expression of the dengue virus envelope protein.","volume":"86","author":"Yan","year":"2014","journal-title":"J. Med. Virol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"e2191","DOI":"10.1128\/JVI.02191-20","article-title":"Tembusu Virus entering the central nervous system caused nonsuppurative encephalitis without disrupting the blood-brain barrier.","volume":"95","author":"Yang","year":"2021","journal-title":"J. Virol."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-016-0562-y","article-title":"miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2.","volume":"13","author":"Yang","year":"2016","journal-title":"Virol. J."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/v11060540","article-title":"Assessing the Potential Interactions between Cellular miRNA and Arboviral Genomic RNA in the Yellow Fever Mosquito.","volume":"11","author":"Yen","year":"2019","journal-title":"Viruses"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-017-0011-5","article-title":"Synthetic miRNAs induce dual arboviral-resistance phenotypes in the vector mosquito.","volume":"1","author":"Yen","year":"2018","journal-title":"Commun. Biol."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.628887","article-title":"Functional Mapping of AGO-Associated Zika Virus-Derived Small Interfering RNAs in Neural Stem Cells.","volume":"11","author":"Zeng","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"4072","DOI":"10.1007\/s12035-018-1358-4","article-title":"Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice.","volume":"56","author":"Zhang","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2021.109127","article-title":"Bta-miR-101 suppresses BEFV replication via targeting NKRF.","volume":"259","author":"Zhao","year":"2021","journal-title":"Vet. Microbiol."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00477","article-title":"ERG-Associated lncRNA (ERGAL) Promotes the Stability and Integrity of Vascular Endothelial Barrier During Dengue Viral Infection via Interaction With miR-183-5p.","volume":"10","author":"Zheng","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.4049\/jimmunol.1900946","article-title":"The Japanese Encephalitis Virus NS1\u2019 Protein Inhibits Type I IFN Production by Targeting MAVS.","volume":"204","author":"Zhou","year":"2020","journal-title":"J. Immunol."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-014-0488-4","article-title":"miR-281, an abundant midgut-specific miRNA of the vector mosquito Aedes albopictus enhances dengue virus replication.","volume":"7","author":"Zhou","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.4049\/jimmunol.1500370","article-title":"MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.","volume":"195","author":"Zhu","year":"2015","journal-title":"J. Immunol."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003088","article-title":"MicroRNA-30e* suppresses dengue virus replication by promoting NF-\u03baB-dependent IFN production.","volume":"8","author":"Zhu","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110091","article-title":"A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes.","volume":"37","author":"Zhu","year":"2021","journal-title":"Cell Rep."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.869441\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T08:08:51Z","timestamp":1649664531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.869441\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":114,"alternative-id":["10.3389\/fmicb.2022.869441"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2022.869441","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]},"article-number":"869441"}}