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Microbiol."],"abstract":"<jats:p>Nontyphoidal <jats:italic>Salmonella<\/jats:italic> (NTS) in children remains a growing burden on public health and often causes children to be hospitalized with diarrheic symptoms. In this work, 260 strains of human <jats:italic>Salmonella<\/jats:italic> isolated from Jilin, China were characterized by serotypes and antimicrobial resistance using whole genome sequencing (WGS). The most prevalent serotype was <jats:italic>Salmonella enteritidis<\/jats:italic> (47.3%), followed by <jats:italic>S<\/jats:italic>. I 4,[5],12:i:- (33.1%), and <jats:italic>Salmonella Typhimurium<\/jats:italic> (7.3%). Furthermore, the consistency between resistance phenotype and genotype was confirmed. Similarly, strains harbored <jats:italic>bla<\/jats:italic><jats:sub><jats:italic>TEM<\/jats:italic>\u22121<jats:italic>B<\/jats:italic><\/jats:sub> and <jats:italic>tetA<\/jats:italic> genes were detected, which verified the level of resistant phenotype in \u03b2-lactams and tetracyclines. The presence of a single mutation in <jats:italic>parC, gyrA<\/jats:italic>, and <jats:italic>qnrS1<\/jats:italic> genes corresponding to quinolones was also observed. In our work, multilocus sequence typing (MLST) and core genome multilocus sequence typing (cgMLST) were found to have a high resolution to molecular traceability, and the combination of both was conducive to practical application in an actual situation. Taking all of this into account, we suggested that the comprehensive surveillance of <jats:italic>Salmonella<\/jats:italic> infection in children should be carried out to monitor antimicrobial-resistant trends from various sources and to alert on outbreaks of foodborne diseases to protect public health.<\/jats:p>","DOI":"10.3389\/fmicb.2022.882647","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T07:46:39Z","timestamp":1652687199000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Whole Genome Sequencing, Antibiotic Resistance, and Epidemiology Features of Nontyphoidal Salmonella Isolated From Diarrheic Children: Evidence From North China"],"prefix":"10.3389","volume":"13","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuening","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1009987","DOI":"10.1371\/journal.ppat.1009987","article-title":"Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids","volume":"17","author":"Abuaita","year":"2021","journal-title":"PLoS Pathog."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0176990","DOI":"10.1371\/journal.pone.0176990","article-title":"Clinical features of children with nontyphoidal Salmonella bacteremia: a single institution survey in rural Japan","volume":"12","author":"Aoki","year":"2017","journal-title":"PloS ONE."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1080\/21645515.2018.1504717","article-title":"The global burden and epidemiology of invasive non-typhoidal Salmonella infections","volume":"15","author":"Balasubramanian","year":"2019","journal-title":"Hum. 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