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COVID-19-associated fungal infections caused by predominantly <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> species, and fungi of the order <jats:italic>Mucorales<\/jats:italic> have been reported from several countries to become significant challenge for healthcare system. Early diagnosis and adequate antifungal therapy is essential to improve clinical outcomes, however, drug resistance shows a rising trend highlighting the need for alternative therapeutic agents. The purpose of this review is to summarize the current knowledge on COVID-19-associated mycoses, treatment strategies and the most recent advancements in antifungal drug development focusing on peptides with antifungal activity.<\/jats:p>","DOI":"10.3389\/fmicb.2022.919501","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T08:02:05Z","timestamp":1654761725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["COVID-19-Associated Fungal Infections: An Urgent Need for Alternative Therapeutic Approach?"],"prefix":"10.3389","volume":"13","author":[{"given":"Marianna","family":"Dom\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n","family":"B\u00e1nyai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1016\/S2213-2600(20)30237-X","article-title":"Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19.","volume":"8","author":"Alanio","year":"2020","journal-title":"Lancet Respir. 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