{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:30:08Z","timestamp":1789230608884,"version":"build-2803163510"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802250"],"award-info":[{"award-number":["31802250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>This study aims to evaluate the effects of<jats:italic>Lactiplantibacillus plantarum<\/jats:italic>19-2 (<jats:italic>L. plantarum<\/jats:italic>19-2) on mice treated with the alkylating agent cyclophosphamide (CTX). Our findings show that<jats:italic>L. plantarum<\/jats:italic>19-2 restored the spleen and thymus index and the number of white blood cells and lymphocytes% in CTX treated mice. Serum immunoglobulin levels in CTX-treated mice were increased by<jats:italic>L. plantarum<\/jats:italic>19-2. In addition, as compared to the model group,<jats:italic>L. plantarum<\/jats:italic>19-2 upregulated the content of SIgA, while<jats:italic>L. plantarum<\/jats:italic>19-2 regulates the mRNA and protein expression levels of GATA-3, T-bet, IFN-\u03b3, and IL-4 in small intestinal tissues, which adjusted mucosal barriers, structural status, and the balance of Helper T-cell 1 and Helper T-cell 2.<jats:italic>Lactiplantibacillus plantarum<\/jats:italic>19-2 regulated the distribution of intestinal flora in mice, promoting the growth of<jats:italic>Bacteroides<\/jats:italic>and<jats:italic>Proteobacteria<\/jats:italic>. In addition,<jats:italic>L. plantarum<\/jats:italic>19-2 inhibited the growth of several harmful bacteria, including<jats:italic>Actinobacteria<\/jats:italic>and<jats:italic>Firmicutes<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fmicb.2022.926756","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T06:33:32Z","timestamp":1659594812000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Lactiplantibacillus plantarum 19-2 on immunomodulatory function and gut microbiota in mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuannuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4049\/jimmunol.159.2.664","article-title":"Type 1 versus type 2 cytokine release by Vbeta T cell subpopulations determines in vivo antitumor reactivity: IL-10 mediates a suppressive role","volume":"159","author":"Aruga","year":"1997","journal-title":"J. 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