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In the context of increasing antibiotic resistance globally, the use of antiseptics as the main active agent and potentiator of antibiotics for the treatment of purulent-inflammatory complications of traumatic wounds, burns, and surgical wounds can be considered to tackle opportunistic infections and their prevention during war. This study presents a comparative investigation of the antimicrobial efficacy of antiseptics used for surgical antisepsis and antiseptic treatment of skin, mucous membranes, and wounds against multidrug-resistant clinical isolates of <jats:italic>Acinetobacter baumannii<\/jats:italic> as a wound pathogen of critical priority (according to the WHO). It was found that strains of <jats:italic>A. baumannii<\/jats:italic>, which have natural and acquired resistance to antimicrobial drugs, remain susceptible to modern antiseptics. Antiseptic drugs based on decamethoxine, chlorhexidine, octenidine, polyhexanide, and povidone-iodine 10% and 2% provide effective bactericidal activity against <jats:italic>A. baumannii<\/jats:italic> within the working concentrations of these drugs. Chlorhexidine and decamethoxine can inhibit biofilm formation by <jats:italic>A. baumannii<\/jats:italic> cells. In terms of bactericidal properties and biofilm formation inhibition, chlorhexidine and decamethoxine are the most effective of all tested antiseptics.<\/jats:p>","DOI":"10.3389\/fmicb.2022.932467","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T06:24:15Z","timestamp":1664864655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds"],"prefix":"10.3389","volume":"13","author":[{"given":"Tetyana Valeriyivna","family":"Denysko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr Adamovych","family":"Nazarchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Gruzevskyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliia \u00c0natoliivna","family":"Bahniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro Valeriiovych","family":"Dmytriiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman Mykolayovych","family":"Chornopyschuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vira Volodymyrivna","family":"Bebyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/2277-9531.127596","article-title":"Comparison of the effects of povidone-iodine and chlorhexidine solutions on skin bacterial flora among hospitalized infants.","volume":"3","author":"Abdeyazdan","year":"2014","journal-title":"J. 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