{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:51:24Z","timestamp":1790027484785,"version":"4.0.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Salmonella<\/jats:italic> is one of the leading causes of foodborne illnesses worldwide. The rapid emergence of multidrug-resistant <jats:italic>Salmonella<\/jats:italic> strains has increased global concern for salmonellosis. Recent studies have shown that bacteriophages (phages) are novel and the most promising antibacterial agents for biocontrol in foods because phages specifically kill target bacteria without affecting other bacteria, do not alter organoleptic properties or nutritional quality of foods, and are safe and environmentally friendly. Due to the vast variation in <jats:italic>Salmonella<\/jats:italic> serotypes, large numbers of different and highly virulent <jats:italic>Salmonella<\/jats:italic> phages with broad host ranges are needed. This study isolated 14 <jats:italic>Salmonella<\/jats:italic> phages from turkey fecal and cecal samples. Six phages (\u03a6205, \u03a6206, \u03a6207, \u03a6Ent, \u03a6Mont, and \u03a613314) were selected for characterization. These phages were from all three families in the <jats:italic>Caudovirales<\/jats:italic> order. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) revealed that each phage had a unique structural protein profile. Each phage had a distinct host range. \u03a6207 and \u03a6Ent are both siphophages. They shared eight hosts, including seven different <jats:italic>Salmonella<\/jats:italic> serovars and one <jats:italic>Shigella sonnei<\/jats:italic> strain. These two phages showed different restriction banding patterns generated through <jats:italic>Eco<\/jats:italic>RI or <jats:italic>Hin<\/jats:italic>dIII digestion, but shared three bands from <jats:italic>Eco<\/jats:italic>RI digestion. \u03a6Ent displayed the broadest and very unusual host range infecting 11 <jats:italic>Salmonella<\/jats:italic> strains from nine serovars and three <jats:italic>Shigella<\/jats:italic> strains from two species, and thus was further characterized. The one-step growth curve revealed that \u03a6Ent had a short latent period (10 min) and relatively large burst size (100 PFU\/infected cell). \u03a6Ent and its host showed better thermal stabilities in tryptic soy broth than in saline at 63 or 72\u00b0C. In the model food system (cucumber juice or beef broth), \u03a6Ent infection [regardless of the multiplicity of infections (MOIs) of 1, 10, and 100] resulted in more than 5-log<jats:sub>10<\/jats:sub> reduction in <jats:italic>Salmonella<\/jats:italic> concentration within 4 or 5 h. Such high lytic activity combined with its remarkably broad and unusual host range and good thermal stability suggested that \u03a6Ent is a novel <jats:italic>Salmonella<\/jats:italic> phage with great potential to be used as an effective biocontrol agent against diverse <jats:italic>Salmonella<\/jats:italic> serovars in foods.<\/jats:p>","DOI":"10.3389\/fmicb.2022.933751","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:03:52Z","timestamp":1657008232000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Bacteriophages Isolated From Turkeys Infecting Diverse Salmonella Serovars"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhongjing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Melgarejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzhuliya","family":"Ignatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kopi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Damaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy","family":"Trejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Paramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Breidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Kathariou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3389\/fmicb.2017.00981","article-title":"Editorial: phage therapy: past, present and future.","volume":"8","author":"Abedon","year":"2017","journal-title":"Front. 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