{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:16:30Z","timestamp":1790619390115,"version":"4.1.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid\u2013base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.<\/jats:p>","DOI":"10.3389\/fmicb.2022.935688","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T06:36:37Z","timestamp":1660113397000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenjing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzheng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangyu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0193594","DOI":"10.1371\/journal.pone.0193594","article-title":"Detection of human bocavirus in Saudi healthy blood donors","volume":"13","author":"Abdel-Moneim","year":"2018","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1099\/jmm.0.001243","article-title":"Detection and phylogenetic analysis of Human bocavirus in children diagnosed with acute respiratory tract infection","volume":"69","author":"Abozahra","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3201\/eid1003.030252","article-title":"Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes","volume":"10","author":"Albrich","year":"2004","journal-title":"Emerging Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"104453","DOI":"10.1016\/j.jcv.2020.104453","article-title":"Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort","volume":"129","author":"Bagasi","year":"2020","journal-title":"J. Clin. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1128\/JCM.01062-09","article-title":"Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States","volume":"47","author":"Blinkova","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1002\/jmv.24562","article-title":"Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children","volume":"88","author":"Calvo","year":"2016","journal-title":"J. Med. Virol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"20058","DOI":"10.1038\/s41598-021-99608-y","article-title":"Respiratory viral infections in pragmatically selected adults in intensive care units","volume":"11","author":"Cia","year":"2021","journal-title":"Sci. Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1146\/annurev-virology-031413-085444","article-title":"Parvoviruses: Small Does Not Mean Simple","volume":"1","author":"Cotmore","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nmeth.2109","article-title":"jModelTest 2: more models, new heuristics and parallel computing","volume":"9","author":"Darriba","year":"2012","journal-title":"Nat. Methods"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5365\/wpsar.2021.12.4.835","article-title":"Capacity and use of diagnostics and treatment for patients with severe acute respiratory infections in the pre-COVID-19 era in district and provincial hospitals in Viet Nam","volume":"12","year":"2021","journal-title":"Western Pac. Surveill. Response J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.13242\/j.cnki.bingduxuebao.003636","article-title":"Study on the function of encoding protein of human Bocavirus","volume":"36","author":"De","year":"2020","journal-title":"Chin. J. Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e99419","DOI":"10.1371\/journal.pone.0099419","article-title":"Viral etiologies of hospitalized acute lower respiratory infection patients in China, 2009-2013","volume":"9","author":"Feng","year":"2014","journal-title":"PLoS ONE"},{"key":"B13","first-page":"954","article-title":"Determination of the adenosine deaminase value in pleural tuberculosis","volume":"81","author":"Fielli","year":"2021","journal-title":"Medicina"},{"key":"B14","first-page":"383","article-title":"The human bocavirus role in acute respiratory tract infections of pediatric patients as defined by viral load quantification","volume":"30","author":"Gerna","year":"2007","journal-title":"New Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"8684","DOI":"10.3748\/wjg.v22.i39.8684","article-title":"Human bocavirus: current knowledge and future challenges","volume":"22","author":"Guido","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.3201\/eid1510.090337","article-title":"Human bocavirus 2 in children, South Korea","volume":"15","author":"Han","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3969\/j.issn.1672-2981.2012.02.019","article-title":"Participation of clinical pharmacists in consultation on 151 cases of intractable infectious diseases","volume":"10","author":"He","year":"2012","journal-title":"Cent. South Pharm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.11852\/zgetbjzz2020-1070","article-title":"Clinical analysis of bocavirus co-infection in children's lower respiratory tract","volume":"29","author":"He","year":"2021","journal-title":"Chin. J. Child Health Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1006770","DOI":"10.1371\/journal.ppat.1006770","article-title":"Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: a key role for mathematical modelling","volume":"14","author":"Hobman","year":"2018","journal-title":"PLoS Pathog."},{"key":"B20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e1002899","DOI":"10.1371\/journal.ppat.1002899","article-title":"Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia","volume":"8","author":"Huang","year":"2012","journal-title":"PLoS Pathog."},{"key":"B22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1684\/vir.2011.3471","article-title":"Cloning of a human parvovirus by molecular screening of respiratory tract samples","volume":"10","author":"Ingrand","year":"2006","journal-title":"Virologie"},{"key":"B23","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3389\/fmicb.2016.00800","article-title":"Clinical features of severe or fatal Mycoplasma pneumoniae pneumonia","volume":"7","author":"Izumikawa","year":"2016","journal-title":"Front. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/rmv.720","article-title":"Human bocavirus-the first 5 years","volume":"22","author":"Jartti","year":"2012","journal-title":"Rev. Med. Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12985-021-01682-1","article-title":"Epidemiologic and clinical characteristics of human bocavirus infection in infants and young children suffering with community acquired pneumonia in Ningxia, China","volume":"18","author":"Ji","year":"2021","journal-title":"Virol. J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1086\/652416","article-title":"Human bocaviruses are highly diverse, dispersed, recombination prone, and prevalent in enteric infections","volume":"201","author":"Kapoor","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13104-017-2620-y","article-title":"Phylogenic analysis of human bocavirus detected in children with acute respiratory infection in Yaounde, Cameroon","volume":"10","author":"Kenmoe","year":"2017","journal-title":"BMC Res. Notes"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1086\/508213","article-title":"Human bocavirus infection in young children in the United States:molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus","volume":"194","author":"Kesebir","year":"2006","journal-title":"J. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/7035081","article-title":"Prevalence and genetic characteristics of human bocaviruses detected in patients with acute respiratory infections in Bulgaria","volume":"2021","author":"Korsun","year":"2021","journal-title":"Int. J. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1128\/JCM.00098-12","article-title":"Detection of human bocaviruses 1 to 4 from nasopharyngeal swab samples collected from patients with respiratory tract infections","volume":"50","author":"Koseki","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"B32","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.829420","article-title":"Heart involvement in multisystem inflammatory syndrome, associated with COVID-19 in children: the retrospective multicenter cohort data","volume-title":"Front. Pediatr","author":"Kostik","year":"2022"},{"key":"B33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1365-3083.2010.02483.x","article-title":"Comparison of Th-cell immunity against human bocavirus and parvovirus B19: proliferation and cytokine responses are similar in magnitude but more closely interrelated with human bocavirus","volume":"73","author":"Kumar","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0217821","DOI":"10.1128\/spectrum.02178-21","article-title":"Contamination of human bocavirus genotypes 1, 2, 3, and 4 in environmental waters in Thailand","volume":"9","author":"Kumthip","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ijid.2020.03.046","article-title":"Human Bocavirus genotypes 1 and 2 detected in younger Amazonian children with acute gastroenteritis or respiratory infections, respectively","volume":"95","author":"Leitao","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1186\/s13104-018-3605-1","article-title":"Detection of human bocavirus-1 in both nasal and stool specimens from children under 5 years old with influenza-like illnesses or diarrhea in Gabon","volume":"11","author":"Lekana-Douki","year":"2018","journal-title":"BMC Res. Notes"},{"key":"B37","first-page":"489","article-title":"Epidemiological and genetic characteristics of adenovirus among hospitalized children with pneumonia in Shijiazhuang, Hebei province","volume":"28","author":"Li","year":"","journal-title":"Int. J. Virol."},{"key":"B38","article-title":"Epidemiological and genetic characteristics of human rhinovirus in hospitalized children with pneumonia in a sentinel hospital in Shijiazhuang,Hebei province of China in 2018 to 2020","volume-title":"Chin. J. Viral. Dis.","year":""},{"key":"B39","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1038\/s41467-021-25120-6","article-title":"Etiological and epidemiological features of acute respiratory infections in China","volume":"12","author":"Li","year":"","journal-title":"Nat. Commun."},{"key":"B40","first-page":"389","article-title":"Mycoplasma pneumoniae detection in throat swabs and bronchoalveolar lavage fluid in children with mycoplasmal pneumonia by real-time PCR and culture","volume":"34","author":"Liu","year":"2019","journal-title":"Dis. Surveill."},{"key":"B41","doi-asserted-by":"publisher","first-page":"258","DOI":"10.11726\/j.issn.1001-7658.2018.04.006","article-title":"Analysis on risk factors and antibiotic resistance of nosocomial infection caused by Stenotrophomonas maltophilia","volume":"35","author":"Liu","year":"","journal-title":"Chin. J. Disinfect."},{"key":"B42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.11726\/j.issn.1001-7658.2018.02.010","article-title":"Distribution and antimicrobial resistance of Stenotrophomonas maltophilia of a geriatric hospital","volume":"35","author":"Liu","year":"","journal-title":"Chin. J. Disinfect."},{"key":"B43","volume-title":"Epidemiological and Genetic Characteristics of Respiratory Viruses in the Children with Acute Respiratory Tract Infection","author":"Lu","year":"2013"},{"key":"B44","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3325\/cmj.2013.54.122","article-title":"Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age \u2013 a systematic review and meta-analysis","volume":"54","author":"Luk\u0161i\u0107","year":"2013","journal-title":"Croat. Med. J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1423-0410.2012.01605.x","article-title":"Human parvovirus PARV4 in plasma pools of Chinese origin","volume":"103","author":"Ma","year":"2012","journal-title":"Vox. Sang."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1099\/jmm.0.001219","article-title":"Human bocavirus (HBoV) in Kuwait: molecular epidemiology and clinical outcome of the virus among patients with respiratory diseases","volume":"69","author":"Madi","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1093\/infdis\/jiv044","article-title":"Human bocavirus 1 primary infection and shedding in infants","volume":"212","author":"Martin","year":"2015","journal-title":"J. Infect. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/jmv.24346","article-title":"Detection of human bocavirus type 1 infection in Panamanian children with respiratory illness","volume":"88","author":"Moreno","year":"2016","journal-title":"J. Med. Virol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1097\/INF.0b013e3181b6d7ec","article-title":"Microbial interactions in the respiratory tract","volume":"28","author":"Murphy","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jiph.2020.12.007","article-title":"Human bocavirus genotypes 1, 2, and 3 circulating in pediatric patients with acute gastroenteritis in Chiang Mai, Thailand, 2012-2018","volume":"14","author":"Nantachit","year":"2021","journal-title":"J. Infect. Public Health"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/jmv.25634","article-title":"Molecular epidemiology of human bocavirus infection in hospitalized children with acute gastroenteritis in South Africa, 2009-2015","volume":"92","author":"Netshikweta","year":"2020","journal-title":"J. Med. Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e4392","DOI":"10.1093\/cid\/ciaa1149","article-title":"Role of human bocavirus respiratory tract infection in hematopoietic cell transplant recipients","volume":"73","author":"Ogimi","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12519-019-00324-5","article-title":"Human bocavirus in children hospitalized for acute respiratory tract infection in Rome","volume":"16","author":"Petrarca","year":"2020","journal-title":"World J. Pediatr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3390\/diagnostics12040824","article-title":"The utility of laboratory parameters for cardiac inflammation in heart failure patients hospitalized with SARS-CoV-2 infection","volume":"12","author":"Pilut","year":"2022","journal-title":"Diagnostics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1128\/CMR.00030-07","article-title":"Human bocavirus: passenger or pathogen in acute respiratory tract infections?","volume":"21","author":"Schildgen","year":"2008","journal-title":"Clin. Microbiol. Rev"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1002\/jmv.25812","article-title":"Molecular and epidemiological trends of human bocavirus and adenovirus in children with acute gastroenteritis in Bangladesh during 2015 to 2019","volume":"92","author":"Sharif","year":"2020","journal-title":"J. Med. Virol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"10097","DOI":"10.1128\/JVI.01374-15","article-title":"Identification and functional analysis of novel nonstructural proteins of human bocavirus 1","volume":"89","author":"Shen","year":"2015","journal-title":"J. Virol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12879-015-0779-1","article-title":"Identification of viral and bacterial pathogens from hospitalized children with severe acute respiratory illness in Lusaka, Zambia, 2011-2012: a cross-sectional study","volume":"15","author":"Simusika","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-virology-092818-015803","article-title":"Emerging human parvoviruses: the rocky road to fame","volume":"6","author":"Soderlund-Venermo","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1093\/tropej\/fmy057","article-title":"Impact of RSV coinfection on human bocavirus in children with acute respiratory infections","volume":"65","author":"Sun","year":"2019","journal-title":"J. Trop. Pediatr."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1002\/jmv.22120","article-title":"Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa","volume":"83","author":"Venter","year":"2011","journal-title":"J. Med. Virol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1007\/s00705-019-04396-6","article-title":"Human bocavirus infection in Belgian children with respiratory tract disease","volume":"164","author":"Verbeke","year":"2019","journal-title":"Arch. Virol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ptdy.2018.01.022","article-title":"Antibacterial therapy for A case of premature infant infected by stenotrophomonas maltophilia participated by clinical pharmacists","volume":"24","author":"Wang","year":"2018","journal-title":"J. Pediatr. Pharm."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e742","DOI":"10.1097\/MD.0000000000000742","article-title":"Detection of viral and bacterial pathogens in hospitalized children with acute respiratory illnesses, Chongqing, 2009-2013","volume":"94","author":"Wei","year":"2015","journal-title":"Medicine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"134","DOI":"10.7883\/yoken.JJID.2017.412","article-title":"Detection of viruses and Mycoplasma pneumoniae in hospitalized patients with severe acute respiratory infection in Northern China, 2015-2016","volume":"71","author":"Xu","year":"2018","journal-title":"Jpn. J. Infect. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"100061","DOI":"10.1016\/j.xinn.2020.100061","article-title":"Laboratory diagnosis and monitoring the viral shedding of SARS-CoV-2 infection","volume":"1","author":"Yang","year":"2020","journal-title":"Innovation"},{"key":"B68","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-022-03170-x","article-title":"Kidney injury and oxidative damage alleviation by Zingiber officinale: pharmacokinetics and protective approach in a combined murine model of osteoporosis","volume-title":"3 Biotech","author":"Zammel","year":"2022"},{"key":"B69","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/ppul.23030","article-title":"The global burden of respiratory disease-impact on child health","volume":"49","author":"Zar","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1099\/vir.0.028340-0","article-title":"Complete coding sequences and phylogenetic analysis of porcine bocavirus","volume":"92","author":"Zeng","year":"2011","journal-title":"J. Gen. Virol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/jmv.25674","article-title":"Recent advances in the detection of respiratory virus infection in humans","volume":"92","author":"Zhang","year":"2020","journal-title":"J. Med. Virol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3000605211027739","DOI":"10.1177\/03000605211027739","article-title":"Human bocavirus-1 screening in infants with acute lower respiratory tract infection","volume":"49","author":"Zhang","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13256-019-2222-5","article-title":"Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report","volume":"13","author":"Ziemele","year":"2019","journal-title":"J. Med. Case Rep."},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.752037","article-title":"Stenotrophomonas maltophilia infections in pediatric patients \u2013 experience at a european center for pediatric hematology and oncology","volume-title":"Front. Oncol.","author":"Z\u00f6llner","year":"2021"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.935688\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T06:36:51Z","timestamp":1660113411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.935688\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":74,"alternative-id":["10.3389\/fmicb.2022.935688"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2022.935688","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]},"article-number":"935688"}}