{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:23:47Z","timestamp":1792873427809,"version":"4.5.0"},"reference-count":199,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , a Gram-negative bacterium, is one of the major pathogens implicated in human opportunistic infection and a common cause of clinically persistent infections such as cystic fibrosis, urinary tract infections, and burn infections. The main reason for the persistence of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infections is due to the ability of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    to secrete extracellular polymeric substances such as exopolysaccharides, matrix proteins, and extracellular DNA during invasion. These substances adhere to and wrap around bacterial cells to form a biofilm. Biofilm formation leads to multiple antibiotic resistance in\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , posing a significant challenge to conventional single antibiotic therapeutic approaches. It has therefore become particularly important to develop anti-biofilm drugs. In recent years, a number of new alternative drugs have been developed to treat\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infectious biofilms, including antimicrobial peptides, quorum-sensing inhibitors, bacteriophage therapy, and antimicrobial photodynamic therapy. This article briefly introduces the process and regulation of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    biofilm formation and reviews several developed anti-biofilm treatment technologies to provide new directions for the treatment of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    biofilm infection.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2022.955286","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T05:28:54Z","timestamp":1661491734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":149,"title":["Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies"],"prefix":"10.3389","volume":"13","author":[{"given":"Rui","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e3210","DOI":"10.1002\/psc.3210","article-title":"Bacterial resistance to antimicrobial peptides","volume":"25","author":"Abdi","year":"2019","journal-title":"J. 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