{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:27:42Z","timestamp":1783690062205,"version":"3.55.0"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0907803"],"award-info":[{"award-number":["2020YFA0907803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900056"],"award-info":[{"award-number":["31900056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000096"],"award-info":[{"award-number":["32000096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The microbiota plays a crucial role in individuals\u2019 early and long-term health. Previous studies indicated that the microbial regulation of health may start before birth. As the <jats:italic>in utero<\/jats:italic> environment is (nearly) sterile, the regulation is probably be originated from maternal microbiota and mediated by their metabolites transferred across the placenta. After the birth, various metabolites are continuously delivered to offspring through human milk feeding. Meanwhile, some components, for example, human milk oligosaccharides, in human milk can only be fermented by microbes, which brings beneficial effects on offspring health. Hence, we speculated that human milk-derived metabolites may also play roles in microbial regulation. However, reports between maternal-associated microbial metabolites and offspring diseases are still lacking and sparsely distributed in several fields. Also, the definition of the maternal-associated microbial metabolite is still unclear. Thus, it would be beneficial to comb through the current knowledge of these metabolites related to diseases for assisting our goals of early prediction, early diagnosis, early prevention, or early treatment through actions only on mothers. Therefore, this review aims to present studies showing how researchers came to the path of investigating these metabolites and then to present studies linking them to the development of offspring asthma, type 1 diabetes mellitus, food allergy, neonatal necrotizing enterocolitis, or autism spectrum disorder. Potential English articles were collected from PubMed by searching terms of disease(s), maternal, and a list of microbial metabolites. Articles published within 5 years were preferred.<\/jats:p>","DOI":"10.3389\/fmicb.2022.955297","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T06:04:40Z","timestamp":1667541880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Microbial regulation of offspring diseases mediated by maternal-associated microbial metabolites"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingru","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfang","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17228.1","article-title":"Recent advances in understanding necrotizing enterocolitis.","volume":"8","author":"Alganabi","year":"2019","journal-title":"F1000Res"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/all.14234","article-title":"Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner.","volume":"75","author":"Alhasan","year":"2020","journal-title":"Allergy"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8081119","article-title":"The infant gut microbiota and risk of asthma: The effect of maternal nutrition during pregnancy and lactation.","volume":"8","author":"Alsharairi","year":"","journal-title":"Microorganisms"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249580","article-title":"The role of short-chain fatty acids in the interplay between a very low-calorie ketogenic diet and the infant gut microbiota and its therapeutic implications for reducing asthma.","volume":"21","author":"Alsharairi","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B5","year":"2013","journal-title":"."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77265-x","article-title":"Unique maternal immune and functional microbial profiles during prenatal stress.","volume":"10","author":"Antonson","year":"2020","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000811","article-title":"Effect of single versus multistrain probiotic in extremely preterm infants: A randomised trial.","volume":"9","author":"Athalye-Jape","year":"2022","journal-title":"BMJ Open Gastroenterol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1136\/gutjnl-2016-312819","article-title":"Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants.","volume":"67","author":"Autran","year":"2018","journal-title":"Gut"},{"key":"B9","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/ismej.2015.151","article-title":"Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants.","volume":"10","author":"Berni Canani","year":"2016","journal-title":"ISME J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1136\/gutjnl-2020-320951","article-title":"Multiomics analysis reveals the presence of a microbiome in the gut of fetal lambs.","volume":"70","author":"Bi","year":"2021","journal-title":"Gut"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1056\/NEJMoa1503734","article-title":"Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring.","volume":"375","author":"Bisgaard","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/glycob\/cws074","article-title":"Human milk oligosaccharides: Every baby needs a sugar mama.","volume":"22","author":"Bode","year":"2012","journal-title":"Glycobiology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/1178646920928984","article-title":"Tryptophan metabolites along the microbiota-gut-brain axis: An interkingdom communication system influencing the gut in health and disease.","volume":"13","author":"Bosi","year":"2020","journal-title":"Int. J. Tryptophan Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the diagnosis and management of food allergy in the United States: Summary of the NIAID-sponsored expert panel report.","volume":"126","author":"Boyce","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00876-5","article-title":"Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe- and CCL2-dependent mechanisms.","volume":"10","author":"Chen","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124497","article-title":"The brain-gut-microbiome system: Pathways and implications for autism spectrum disorder.","volume":"13","author":"Chernikova","year":"2021","journal-title":"Nutrients"},{"key":"B17","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/advances\/nmab122","article-title":"Potential biomarkers, risk factors, and their associations with IgE-mediated food allergy in early life: A narrative review.","volume":"13","author":"Childs","year":"2022","journal-title":"Adv. Nutr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/rheumatology\/keaa835","article-title":"The oral and gut microbiome in rheumatoid arthritis patients: A systematic review.","volume":"60","author":"Chu","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010025","article-title":"The role of succinate in the regulation of intestinal inflammation.","volume":"11","author":"Connors","year":"2018","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/jmd2.12083","article-title":"High prevalence of self-reported autism spectrum disorder in the propionic acidemia registry.","volume":"51","author":"Cotrina","year":"2020","journal-title":"JIMD Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis.","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1093\/eurheartj\/ehab605","article-title":"Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection.","volume":"42","author":"Cui","year":"2021","journal-title":"Eur. Heart J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00125-019-05073-8","article-title":"Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: A randomised controlled trial.","volume":"63","author":"de Groot","year":"2020","journal-title":"Diabetologia"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00078","article-title":"The role of gut microbiota and environmental factors in type 1 diabetes pathogenesis.","volume":"11","author":"Dedrick","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/S0140-6736(14)60615-2","article-title":"Diagnosis, management, and prognosis of preschool wheeze.","volume":"383","author":"Ducharme","year":"2014","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03157-4","article-title":"Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation.","volume":"9","author":"Durack","year":"2018","journal-title":"Nat. Commun."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01274-1","article-title":"Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring.","volume":"11","author":"Fernandes","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087072","article-title":"Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner.","volume":"9","author":"Foley","year":"2014","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010123","article-title":"The role of the microbiome in asthma: The gut-lung axis.","volume":"20","author":"Frati","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109521","article-title":"A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state.","volume":"36","author":"Fremder","year":"2021","journal-title":"Cell Rep."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105664","article-title":"Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia.","volume":"138","author":"Fu","year":"2020","journal-title":"Environ. Int."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113471","article-title":"Prenatal stress-induced disruptions in microbial and host tryptophan metabolism and transport.","volume":"414","author":"Galley","year":"2021","journal-title":"Behav. Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.aba0478","article-title":"Microbial-host molecular exchange and its functional consequences in early mammalian life.","volume":"368","author":"Ganal-Vonarburg","year":"2020","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"G521","DOI":"10.1152\/ajpgi.00279.2020","article-title":"Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo.","volume":"320","author":"Gao","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice.","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658354","article-title":"Impact of bacterial metabolites on gut barrier function and host immunity: A focus on bacterial metabolism and its relevance for intestinal inflammation.","volume":"12","author":"Gasaly","year":"2021","journal-title":"Front. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1126\/science.aad2571","article-title":"The maternal microbiota drives early postnatal innate immune development.","volume":"351","author":"Gomez de Ag\u00fcero","year":"2016","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00365","article-title":"The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma.","volume":"8","author":"Gray","year":"2017","journal-title":"Front. Immunol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03109-5","article-title":"Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells.","volume":"19","author":"He","year":"2021","journal-title":"J. Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3884","DOI":"10.1016\/j.cell.2021.05.030","article-title":"Bifidobacteria-mediated immune system imprinting early in life.","volume":"184","author":"Henrick","year":"2021","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/fsn3.2682","article-title":"Anti-inflammatory actions of acetate, propionate, and butyrate in fetal mouse jejunum cultures ex vivo and immature small intestinal cells in vitro.","volume":"10","author":"Huang","year":"2022","journal-title":"Food Sci. Nutr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/Mcp.0000000000000124","article-title":"The respiratory microbiome and innate immunity in asthma.","volume":"21","author":"Huang","year":"2015","journal-title":"Curr. Opin. Pulm. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus.","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76109-y","article-title":"Butyrate induced tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes.","volume":"10","author":"Jacob","year":"2020","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1136\/gutjnl-2011-301404","article-title":"The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats.","volume":"61","author":"Jantscher-Krenn","year":"2012","journal-title":"Gut"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1021\/acs.jafc.9b07701","article-title":"Butyrate ameliorates antibiotic-driven type 1 diabetes in the female offspring of nonobese diabetic mice.","volume":"68","author":"Jia","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1039\/c7fo01979c","article-title":"The impact of lactation and gestational age on the composition of branched-chain fatty acids in human breast milk.","volume":"9","author":"Jie","year":"2018","journal-title":"Food Funct."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000521192","article-title":"Antibiotic treatments prolong the wheezing period in acute exacerbation of childhood bronchial asthma.","volume":"2022","author":"Kama","year":"2022","journal-title":"Int. Arch. Allergy Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nature23910","article-title":"Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.","volume":"549","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/s41564-021-00970-4","article-title":"Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut.","volume":"6","author":"Laursen","year":"2021","journal-title":"Nat. Microbiol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-020-00120-x","article-title":"The gut microbiota, environmental factors, and links to the development of food allergy.","volume":"18","author":"Lee","year":"2020","journal-title":"Clin. Mol. Allergy"},{"key":"B53","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jaci.2022.02.005","article-title":"Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma.","volume":"150","author":"Lee-Sarwar","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.138751","article-title":"In utero human intestine harbors unique metabolome, including bacterial metabolites.","volume":"5","author":"Li","year":"2020","journal-title":"JCI Insight"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36430-z","article-title":"Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder.","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0138-4","article-title":"Autism spectrum disorder.","volume":"6","author":"Lord","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21356-4","article-title":"Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis.","volume":"12","author":"Lu","year":"2021","journal-title":"Nat. Commun."},{"key":"B58","author":"Lucier","year":"2022","journal-title":"Diabetes mellitus type 1"},{"key":"B59","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nri.2017.58","article-title":"How nutrition and the maternal microbiota shape the neonatal immune system.","volume":"17","author":"Macpherson","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/ni.3713","article-title":"Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.","volume":"18","author":"Marino","year":"2017","journal-title":"Nat. Commun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1136\/gutjnl-2020-322771","article-title":"Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis.","volume":"70","author":"Masi","year":"2021","journal-title":"Gut"},{"key":"B62","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41390-019-0740-x","article-title":"Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.","volume":"88","author":"Meng","year":"2020","journal-title":"Pediatr. Res."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060707","article-title":"A systematic review and meta-analysis of human milk feeding and morbidity in very low birth weight infants.","volume":"10","author":"Miller","year":"2018","journal-title":"Nutrients"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4856","DOI":"10.1172\/JCI122631","article-title":"Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation.","volume":"128","author":"Mincham","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1177\/11786469211026639","article-title":"The effects of maternal interleukin-17A on social behavior, cognitive function, and depression-like behavior in mice with altered kynurenine metabolites.","volume":"14","author":"Murakami","year":"2021","journal-title":"Int. J. Tryptophan Res."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03599-2020","article-title":"A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care.","volume":"58","author":"Murray","year":"2021","journal-title":"Eur. Respir. J."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183786","article-title":"Maternal treatment with short-chain fatty acids modulates the intestinal microbiota and immunity and ameliorates type 1 diabetes in the offspring.","volume":"12","author":"Needell","year":"2017","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.biopsych.2020.09.025","article-title":"Plasma and fecal metabolite profiles in autism spectrum disorder.","volume":"89","author":"Needham","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Medical progress: Necrotizing enterocolitis.","volume":"364","author":"Neu","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions.","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jaci.2012.10.026","article-title":"A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.","volume":"131","author":"Noval Rivas","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12020094","article-title":"Vertical transfer of metabolites detectable from newborn\u2019s dried blood spot samples ssing UPLC-MS: A chemometric study.","volume":"12","author":"Olarini","year":"2022","journal-title":"Metabolites"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1084\/jem.20081800","article-title":"Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.","volume":"205","author":"Oresic","year":"2008","journal-title":"J. Exp. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1111\/all.14625","article-title":"Butyrate as a bioactive human milk protective component against food allergy.","volume":"76","author":"Paparo","year":"2021","journal-title":"Allergy"},{"key":"B75","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma.","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"B76","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00125-018-4763-3","article-title":"Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: A multicentre prospective registration study.","volume":"62","author":"Patterson","year":"2019","journal-title":"Diabetologia"},{"key":"B77","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1203\/01.pdr.0000250014.92242.f3","article-title":"Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier.","volume":"61","author":"Peng","year":"2007","journal-title":"Pediatr. Res."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002971.pub5","article-title":"Formula versus donor breast milk for feeding preterm or low birth weight infants.","volume":"7","author":"Quigley","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ebiom.2019.07.057","article-title":"Fish-oil supplementation in pregnancy, child metabolomics and asthma risk.","volume":"46","author":"Rago","year":"2019","journal-title":"EBioMedicine"},{"key":"B80","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1203\/PDR.0b013e318184d2e6","article-title":"Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tract.","volume":"64","author":"Ran-Ressler","year":"2008","journal-title":"Pediatr. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000351396","article-title":"Branched chain fatty acids in the neonatal gut and estimated dietary intake in infancy and adulthood.","volume":"77","author":"Ran-Ressler","year":"2013","journal-title":"Nestle Nutr. Inst. Workshop Ser."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029032","article-title":"Branched chain fatty acids reduce the incidence of necrotizing enterocolitis and alter gastrointestinal microbial ecology in a neonatal rat model.","volume":"6","author":"Ran-Ressler","year":"2011","journal-title":"PLoS One"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1002\/aur.2311","article-title":"Untargeted metabolomics screen of mid-pregnancy maternal serum and autism in offspring.","volume":"13","author":"Ritz","year":"2020","journal-title":"Autism Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/all.13660","article-title":"High levels of butyrate and propionate in early life are associated with protection against atopy.","volume":"74","author":"Roduit","year":"2019","journal-title":"Allergy"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201172","article-title":"Enteral administration of bacteria fermented formula in newborn piglets: A high fidelity model for necrotizing enterocolitis (NEC).","volume":"13","author":"Roy","year":"2018","journal-title":"PLoS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/ni.1657","article-title":"Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.","volume":"9","author":"Rubic","year":"2008","journal-title":"Nat. Immunol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/foods10061429","article-title":"Human milk oligosaccharides (HMOs) and infant microbiota: A scoping review.","volume":"10","author":"Sanchez","year":"2021","journal-title":"Foods"},{"key":"B88","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/j.1651-2227.2008.01215.x","article-title":"Faecal short chain fatty acid pattern and allergy in early childhood.","volume":"98","author":"Sandin","year":"2009","journal-title":"Acta Paediatr."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e1064","DOI":"10.1128\/AEM.01064-18","article-title":"Ethylphenol formation by Lactobacillus plantarum: Identification of the enzyme involved in the reduction of vinylphenols.","volume":"84","author":"Santamaria","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management.","volume":"141","author":"Sicherer","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1111\/jam.15078","article-title":"Bio-therapeutics from human milk: Prospects and perspectives.","volume":"131","author":"Singh","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"B93","doi-asserted-by":"publisher","first-page":"27601","DOI":"10.1074\/jbc.M110.102947","article-title":"Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.","volume":"285","author":"Singh","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis.","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41390-020-0852-3","article-title":"The human milk oligosaccharides 2\u2019-fucosyllactose and 6\u2019-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.","volume":"89","author":"Sodhi","year":"2021","journal-title":"Pediatr. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.tim.2022.02.007","article-title":"Microbial metabolites: The next frontier in human milk.","volume":"30","author":"Stinson","year":"2022","journal-title":"Trends Microbiol."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01427","article-title":"Human milk from atopic mothers has lower levels of short chain fatty acids.","volume":"11","author":"Stinson","year":"2020","journal-title":"Front. Immunol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S2213-2600(14)70152-3","article-title":"Maternal propensity for infections and risk of childhood asthma: A registry-based cohort study.","volume":"2","author":"Stokholm","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.immuni.2015.07.013","article-title":"Pancreatic beta-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota.","volume":"43","author":"Sun","year":"2015","journal-title":"Immunity"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.jaci.2020.10.009","article-title":"Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk.","volume":"147","author":"Tang","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e4062","DOI":"10.1210\/clinem\/dgab400","article-title":"Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the norwegian mother, father, and child cohort.","volume":"106","author":"Tapia","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B102","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development.","volume":"17","author":"Teo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238923","article-title":"Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol.","volume":"15","author":"Terada-Ikeda","year":"2020","journal-title":"PLoS One"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8320","article-title":"Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.","volume":"6","author":"Thorburn","year":"2015","journal-title":"Nat. Commun."},{"key":"B105","doi-asserted-by":"publisher","first-page":"G1115","DOI":"10.1152\/ajpgi.00261.2009","article-title":"Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs.","volume":"297","author":"Thymann","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1093\/cid\/ciaa262","article-title":"Antibiotic treatments during infancy, changes in nasal microbiota, and asthma development: Population-based cohort study.","volume":"72","author":"Toivonen","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1001\/jamapediatrics.2015.2757","article-title":"Association of early exposure of probiotics and islet autoimmunity in the TEDDY study.","volume":"170","author":"Uusitalo","year":"2016","journal-title":"JAMA Pediatr."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.jaci.2020.08.035","article-title":"Type 2-high asthma is associated with a specific indoor mycobiome and microbiome.","volume":"147","author":"Vandenborght","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41586-018-0620-2","article-title":"The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.","volume":"562","author":"Vatanen","year":"2018","journal-title":"Nature"},{"key":"B110","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.cell.2016.04.007","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans.","volume":"165","author":"Vatanen","year":"2016","journal-title":"Cell"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12802","article-title":"Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes.","volume":"79","author":"Vistnes","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14552-1","article-title":"Maternal carriage of prevotella during pregnancy associates with protection against food allergy in the offspring.","volume":"11","author":"Vuillermin","year":"2020","journal-title":"Nat. Commun."},{"key":"B113","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41586-020-2745-3","article-title":"The maternal microbiome modulates fetal neurodevelopment in mice.","volume":"586","author":"Vuong","year":"2020","journal-title":"Nature"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.754401","article-title":"Adjuvant probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 attenuate glycemic levels and inflammatory cytokines in patients with type 1 diabetes mellitus.","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B115","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1097\/01.mpg.0000252184.89922.5f","article-title":"Effects of oral administration of Bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants.","volume":"44","author":"Wang","year":"2007","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.770913","article-title":"Association between breastmilk microbiota and food allergy in infants.","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1146\/annurev.nutr.27.061406.093705","article-title":"Epigenetic epidemiology of the developmental origins hypothesis.","volume":"27","author":"Waterland","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"B118","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/aur.2057","article-title":"Maternal pre-pregnancy body mass index and gestational weight gain in relation to autism spectrum disorder and other developmental disorders in offspring.","volume":"12","author":"Windham","year":"2019","journal-title":"Autism Res."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22052-y","article-title":"Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice.","volume":"8","author":"Xiao","year":"2018","journal-title":"Sci. Rep."},{"key":"B120","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.plipres.2017.10.002","article-title":"Furan fatty acids - beneficial or harmful to health?","volume":"68","author":"Xu","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.708472","article-title":"The role of microbiota in infant health: From early life to adulthood.","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nri.2016.111","article-title":"Food allergy: Immune mechanisms, diagnosis and immunotherapy.","volume":"16","author":"Yu","year":"2016","journal-title":"Nat. Rev. Immunol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.955297\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T06:04:47Z","timestamp":1667541887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2022.955297\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":122,"alternative-id":["10.3389\/fmicb.2022.955297"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2022.955297","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"article-number":"955297"}}