{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:27:58Z","timestamp":1788776878856,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"\n Salmonella enterica<\/jats:italic>\n serotype Indiana (\n S.<\/jats:italic>\n Indiana) in Chinese poultry meat has aroused widespread concern because of its high prevalence and strong antimicrobial resistance. In consideration of the relationship in our previous study between\n S.<\/jats:italic>\n Indiana and co-resistance to ciprofloxacin and cefotaxime (CIP-CTX), which were the first-line drug which were used in\n Salmonella<\/jats:italic>\n infection in clinical, the antimicrobial resistance (AMR) of 224 CIP-CTX co-resistant\n S.<\/jats:italic>\n Indiana isolated from retail chicken samples in China were investigated, with the aim of characterizing the AMR profiles and related resistance mechanisms to ciprofloxacin and cefotaxime among these CIP-CTX co-resistant\n S.<\/jats:italic>\n Indiana isolates, all of which showed multi-drug-resistant (MDR) phenotypes. GyrA (S83F and D87N\/G) with ParC (T57S and S80R) were the dominant amino acid substitution types, with\n oqxA<\/jats:italic>\n ,\n oqxB,<\/jats:italic>\n and\n aac (6\u2032)-Ib-cr<\/jats:italic>\n identified as common plasmid-mediated quinolone resistance (PMQR)-encoding genes. Five\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n gene subtypes were identified with\n bla<\/jats:italic>\n CTX-M-65<\/jats:sub>\n ranking at the top. Equally important, we obtained one isolate CFSA664 harboring the\n mcr-1<\/jats:italic>\n gene was ESBL producer with co-resistance to nine in ten classes of tested drugs inclduing colistin. A single circular chromosome and 3 circular plasmids were found in its genome. Among the 26 AMR genes identified, 24 were located on plasmid pCFSA664-1, including three ESBL genes, while plasmid pCFSA664-3 owning only the\n mcr-1<\/jats:italic>\n gene and sharing the same backbone structure with plasmids from Enterobacteriaceae. No insertion sequences were found near the\n mcr-1<\/jats:italic>\n gene but a relaxase-encoding gene in the flank, which could transfer into\n E. coli<\/jats:italic>\n J53 at a relatively high frequency.\n S.<\/jats:italic>\n Indiana in this study exhibited highly drug-resistant phenotypes, contributing to the acceleration of the dissemination and emergence of this pathogen among different sources. Surveillance and a One Health strategy are needed to limit the emergence of\n S.<\/jats:italic>\n Indiana along the food chain.\n <\/jats:p>","DOI":"10.3389\/fmicb.2022.955827","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T05:30:03Z","timestamp":1662615003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin"],"prefix":"10.3389","volume":"13","author":[{"given":"Yujie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott V.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9amus","family":"Fanning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cmi.2015.12.004","article-title":"Salmonellosis: the role of poultry meat","volume":"22","author":"Antunes","year":"2016","journal-title":"Clin. 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