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Microbiol."],"abstract":"<jats:p>\n                    Considered as the most popular pathogen worldwide,\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is intensively associated with diverse gastric diseases, including gastric ulcers, chronic progressive gastritis, and gastric cancer. Aside from its pathogenic effect on gastric diseases, growing evidences reveal that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    may be related to numerous extragastric diseases. In this article, we reviewed recent studies and systematically elucidated that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    may interfere with many biological processes outside the stomach and influence the occurrence of various extragastric diseases. Many epidemiological studies have indicated that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    plays a pathogenic role in COVID-19, atherosclerosis, hyperemesis gravidarum and several other extragastric diseases, while the effect of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    is currently under investigation in gastroesophageal reflux disease, asthma, and inflammatory bowel disease. Moreover, we also summarized the possible pathogenic mechanisms of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    that may be related to chronic systemic inflammation and molecular mimicker. Taken together, this review provides a new perspective on the role of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    in extragastric diseases and explores the possible mechanisms, which may help guide clinical treatment.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2022.972777","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T02:30:24Z","timestamp":1659580224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Helicobacter pylori and unignorable extragastric diseases: Mechanism and implications"],"prefix":"10.3389","volume":"13","author":[{"given":"Junjian","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5956","article-title":"The Psychotic Impact of Helicobacter pylori Gastritis and Functional Dyspepsia on Depression: A Systematic Review.","volume":"11","author":"Al Quraan","year":"2019","journal-title":"Cureus."},{"key":"B2","first-page":"143","article-title":"Helicobacter pylori eradication in the management of glaucoma.","volume":"11","author":"Ala","year":"2020","journal-title":"Caspian J. 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