{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:25:50Z","timestamp":1777091150079,"version":"3.51.4"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Benzoin resin, produced by the native Indonesian trees<jats:italic>Styrax sumatrana<\/jats:italic>and<jats:italic>Styrax benzoin<\/jats:italic>, has been incorporated into medical practices to treat wounds, erythema, and many other conditions for centuries. Endophytic fungi that reside within medicinal plants have antimicrobial, antioxidant, and \u03b1-glucosidase inhibitory capacities, contributing to plant health and derivative products. In this study, we determined the antifungal, antioxidant, and \u03b1-glucosidase inhibitory capacities of endophytic fungal isolates from three different tissues (leaves, bark, and stems) of<jats:italic>S. sumatrana<\/jats:italic>and<jats:italic>S. benzoin<\/jats:italic>trees. The genera of fungal isolates were determined by phylogenetic analysis of internal transcribed spacer sequences. A total of 58 fungal isolates were classified into 15 different fungal genera from eight taxonomic orders\u2014Hypocreales, Botryosphaeriales, Glomerellales, Diaphortales, Pleosporales, Eurotiales, Xylariales, and Mucorales\u2014with a pattern of host species specificity. Among these isolates,<jats:italic>Trichoderma<\/jats:italic>sp. 6407 consistently exhibited high inhibition of the growth of plant pathogens<jats:italic>Fusarium<\/jats:italic>sp.,<jats:italic>Trichoderma viride<\/jats:italic>, and<jats:italic>Aspergillus niger<\/jats:italic>. With respect to antioxidant activity,<jats:italic>Phyllosticta<\/jats:italic>sp. 6454 consistently showed 2,2-diphenyl-1-picrylhydrazyl inhibition (37.59 \u00b1 0.05%), 2,2\u2032-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)-based antioxidant activity (25.04 \u00b1 0.27 mgTE\/g), and \u03b1-glucosidase inhibitory activity (52.15 \u00b1 10.08%).<jats:italic>Neopestalotiopsis<\/jats:italic>sp. 6431 was notably potent in 2,2-diphenyl-1-picrylhydrazyl inhibition (49.65 \u00b1 0.80%), ferric reducing antioxidant power-based antioxidant activity (197.49 \u00b1 8.65 mgTE\/g), and \u03b1-glucosidase inhibitory activity (52.88 \u00b1 4.93%). This study revealed that<jats:italic>Trichoderma<\/jats:italic>sp. 6407,<jats:italic>Phyllosticta<\/jats:italic>sp. 6454, and<jats:italic>Neopestalotiopsis<\/jats:italic>sp. 6431 exhibited antifungal, antioxidant, and \u03b1-glucosidase inhibitory activities.<\/jats:p>","DOI":"10.3389\/fmicb.2022.974526","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T10:30:48Z","timestamp":1667557848000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Culturable endophytic fungal assemblages from Styrax sumatrana and Stryax benzoin and their potential as antifungal, antioxidant, and alpha-glucosidase inhibitory resources"],"prefix":"10.3389","volume":"13","author":[{"given":"Deni","family":"Elfiati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Asih","family":"Faulina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laras Murni","family":"Rahayu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryanto","family":"Aryanto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizna Triana","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henti Hendalastuti","family":"Rachmat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maman","family":"Turjaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Fathi","family":"Royyani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arida","family":"Susilowati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asep","family":"Hidayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.22207\/JPAM.12.1.38","article-title":"Antimicrobial activity and phytochemical analysis of endophytic fungal extracts isolated from ethno-pharmaceutical plant Rauwolfia tetraphylla L.","volume":"12","author":"Alurappa","year":"2018","journal-title":"J. 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