{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:06:44Z","timestamp":1791576404795,"version":"4.3.4"},"reference-count":126,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Mycoplasma genitalium<\/jats:italic> is a newly emerged sexually transmitted disease pathogen and an independent risk factor for female cervicitis and pelvic inflammatory disease. The clinical symptoms caused by <jats:italic>M. genitalium<\/jats:italic> infection are mild and easily ignored. If left untreated, <jats:italic>M. genitalium<\/jats:italic> can grow along the reproductive tract and cause salpingitis, leading to infertility and ectopic pregnancy. Additionally, <jats:italic>M. genitalium<\/jats:italic> infection in late pregnancy can increase the incidence of preterm birth. <jats:italic>M. genitalium<\/jats:italic> infections are often accompanied by co-infection with other sexually transmitted pathogens (<jats:italic>Chlamydia trachomatis<\/jats:italic>, <jats:italic>Neisseria gonorrhoeae<\/jats:italic>, and <jats:italic>Trichomonas vaginalis<\/jats:italic>) and viral infections (Human Papilloma Virus and Human Immunodeficiency Virus). A recent study suggested that <jats:italic>M. genitalium<\/jats:italic> plays a role in tumor development in the female reproductive system. However, few studies endorsed this finding. In recent years, <jats:italic>M. genitalium<\/jats:italic> has evolved into a new \u201csuperbug\u201d due to the emergence of macrolide-and fluoroquinolone-resistant strains leading to frequent therapy failures. This review summarizes the pathogenic characteristics of <jats:italic>M. genitalium<\/jats:italic> and the female reproductive diseases caused by <jats:italic>M. genitalium<\/jats:italic> (cervicitis, pelvic inflammatory disease, ectopic pregnancy, infertility, premature birth, co-infection, reproductive tumors, etc.), as well as its potential relationship with reproductive tumors and clinical treatment.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1098276","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T07:16:45Z","timestamp":1676963805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Mycoplasma genitalium infection in the female reproductive system: Diseases and treatment"],"prefix":"10.3389","volume":"14","author":[{"given":"Jianwei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zufeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongliang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.gofs.2019.03.009","article-title":"Follow-up and counselling after pelvic inflammatory disease: CNGOF and SPILF pelvic inflammatory diseases guidelines","volume":"47","author":"Ah-Kit","year":"2019","journal-title":"Gynecol. 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