{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:21:22Z","timestamp":1790140882097,"version":"4.0.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Scrub typhus is emerging as a global public health threat owing to its increased prevalence and remarkable geographic expansion. However, it remains a neglected disease, and possible influences of meteorological factors on its risk are poorly understood. We conducted the largest-scale research to assess the impact of meteorological factors on scrub typhus in China. Weekly data on scrub typhus cases and meteorological factors were collected across 59 prefecture-level administrative regions from 2006 to 2020. First, we divided these regions into 3 regions and analyzed the epidemiological characteristics of scrub typhus. We then applied the distributed lag nonlinear model, combined with multivariate meta-analysis, to examine the associations between meteorological factors and scrub typhus incidence at the total and regional levels. Subsequently, we identified the critical meteorological predictors of scrub typhus incidence and extracted climate risk windows. We observed distinct epidemiological characteristics across regions, featuring obvious clustering in the East and Southwest with more even distribution and longer epidemic duration in the South. The mean temperature and relative humidity had profound effects on scrub typhus with initial-elevated-descendent patterns. Weather conditions of weekly mean temperatures of 25\u201333\u00b0C and weekly relative humidity of 60\u201395% were risk windows for scrub typhus. Additionally, the heavy rainfall was associated with sharp increase in scrub typhus incidence. We identified specific climatic signals to detect the epidemic of scrub typhus, which were easily monitored to generalize. Regional heterogeneity should be considered for targeted monitoring and disease control strategies.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1118001","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:41:16Z","timestamp":1677152476000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Impacts of meteorological factors on the risk of scrub typhus in China, from 2006 to 2020: A multicenter retrospective study"],"prefix":"10.3389","volume":"14","author":[{"given":"Ling","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaobin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41579-021-00639-z","article-title":"Infectious disease in an era of global change","volume":"20","author":"Baker","year":"2022","journal-title":"Nat. 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Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3321\/j.issn:1672-3554.2002.01.001","article-title":"Basic studies on trombiculid mites and vector chiggers mites in the transmission of tsutsugamushi disease for 45 years","volume":"23","author":"Li","year":"2002","journal-title":"Acad. J. Sun Yat-Sen Univ. Med. Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.envint.2017.03.011","article-title":"Climate change and human infectious diseases: a synthesis of research findings from global and spatio-temporal perspectives","volume":"103","author":"Liang","year":"2017","journal-title":"Environ. Int."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"667549","DOI":"10.3389\/fmed.2021.667549","article-title":"Impact of meteorological factors and southern oscillation index on scrub typhus incidence in Guangzhou, southern China, 2006-2018","volume":"8","author":"Lu","year":"2021","journal-title":"Front. 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