{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:22:49Z","timestamp":1793532169566,"version":"4.5.0"},"reference-count":142,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is a pathogenic microorganism that mainly resides in the human stomach and is the major cause of chronic gastritis, peptic ulcer and gastric cancer. Up to now, the treatment of <jats:italic>Helicobacter pylori<\/jats:italic> has been predominantly based on a combination of antibiotics and proton pump inhibitors. However, the increasing antibiotic resistance greatly limits the efficacy of anti-<jats:italic>Helicobacter pylori<\/jats:italic> treatment. Turning to non-antibiotic or non-pharmacological treatment is expected to solve this problem and may become a new strategy for treating <jats:italic>Helicobacter pylori<\/jats:italic>. In this review, we outline <jats:italic>Helicobacter pylori<\/jats:italic>\u2019s colonization and virulence mechanisms. Moreover, a series of non-pharmacological treatment methods for <jats:italic>Helicobacter pylori<\/jats:italic> and their mechanisms are carefully summarized, including probiotics, oxygen-rich environment or hyperbaric oxygen therapy, antibacterial photodynamic therapy, nanomaterials, antimicrobial peptide therapy, phage therapy and modified lysins. Finally, we provide a comprehensive overview of the challenges and perspectives in developing new medical technologies for treating <jats:italic>Helicobacter pylori<\/jats:italic> without drugs.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1134254","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T04:51:11Z","timestamp":1679028671000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["A review on the research progress on non-pharmacological therapy of Helicobacter pylori"],"prefix":"10.3389","volume":"14","author":[{"given":"Qian","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugui","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2217\/fvl.13.58","article-title":"Isolation and characterization of bacteriophages of Helicobacter pylori isolated from Egypt","volume":"8","author":"Abdel-Haliem","year":"2013","journal-title":"Future Virol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/antibiotics10020124","article-title":"Phage-encoded endolysins","volume":"10","author":"Abdelrahman","year":"2021","journal-title":"Antibiotics-Basel"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.addr.2018.06.018","article-title":"Use of phage therapy to treat long-standing, persistent, or chronic bacterial infections","volume":"145","author":"Abedon","year":"2019","journal-title":"Adv. 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