{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T16:44:51Z","timestamp":1789317891024,"version":"build-2803163510"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The gut-brain axis has been widely recognized in autism spectrum disorder (ASD), and probiotics are considered to potentially benefit the rescuing of autism-like behaviors. As a probiotic strain, <jats:italic>Lactiplantibacillus plantarum<\/jats:italic><jats:italic>N-1<\/jats:italic>(<jats:italic>LPN-1<\/jats:italic>) was utilized to investigate its effects on gut microbiota and autism-like behaviors in ASD mice constructed by maternal immune activation (MIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult offspring of MIA mice were given <jats:italic>LPN-1<\/jats:italic> at the dosage of 2 \u2009\u00d7\u2009 10<jats:sup>9<\/jats:sup>\u2009 CFU\/g for 4\u2009 weeks before subject to the behavior and gut microbiota evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The behavioral tests showed that <jats:italic>LPN-1<\/jats:italic> intervention was able to rescue autism-like behaviors in mice, including anxiety and depression. In which the <jats:italic>LPN-1<\/jats:italic> treatment group increased the time spent interacting with strangers in the three-chamber test, their activity time and distance in the central area increased in the open field test, and their immobility time decreased when hanging their tails. Moreover, the supplementation of <jats:italic>LPN-1<\/jats:italic> reversed the intestinal flora structure of ASD mice by enhancing the relative abundance of the pivotal microorganisms of <jats:italic>Allobaculum<\/jats:italic> and <jats:italic>Oscillospira<\/jats:italic>, while reducing those harmful ones like <jats:italic>Sutterella<\/jats:italic> at the genus level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results suggested that <jats:italic>LPN-1<\/jats:italic> supplementation may improve autism-like behaviors, possibly <jats:italic>via<\/jats:italic> regulating the gut microbiota.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2023.1134517","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T05:08:05Z","timestamp":1678943285000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactiplantibacillus plantarum N-1 improves autism-like behavior and gut microbiota in mouse"],"prefix":"10.3389","volume":"14","author":[{"given":"Zhongqing","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-230X-11-22","article-title":"Gastrointestinal flora and gastrointestinal status in children with autism\u2014comparisons to typical children and correlation with autism severity","volume":"11","author":"Adams","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"113961","DOI":"10.1016\/j.physbeh.2022.113961","article-title":"Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism","volume":"256","author":"Ad\u0131g\u00fczel","year":"2022","journal-title":"Physiol. 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