{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:41:24Z","timestamp":1782139284815,"version":"3.54.5"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Numerous different species of LAB are used in different fields due to their unique characteristics. However, <jats:italic>Lacticaseibacillus chiayiensis<\/jats:italic>, a newly established species in 2018, has limited microorganism resources, and lacks comprehensive evaluations of its properties. In this study, <jats:italic>L. chiayiensis<\/jats:italic> AACE3, isolated from fermented blueberry, was evaluated by genomic analysis and <jats:italic>in vitro<\/jats:italic> assays of the properties. The genome identified genes associated with biofilm formation (<jats:italic>luxS<\/jats:italic>, <jats:italic>ccpA<\/jats:italic>, <jats:italic>brpA<\/jats:italic>), resistance to oxidative stress (<jats:italic>tpx<\/jats:italic>, <jats:italic>trxA<\/jats:italic>, <jats:italic>trxB<\/jats:italic>, <jats:italic>hslO<\/jats:italic>), tolerance to acidic conditions (<jats:italic>dltA<\/jats:italic>, <jats:italic>dltC<\/jats:italic>), resistance to unfavorable osmotic pressure (<jats:italic>opuBB<\/jats:italic>, <jats:italic>gbuA<\/jats:italic>, <jats:italic>gbuB<\/jats:italic>, <jats:italic>gbuC<\/jats:italic>), and adhesion (<jats:italic>luxS<\/jats:italic>, <jats:italic>dltA<\/jats:italic>, <jats:italic>dltC<\/jats:italic>). The AACE3 showed 112 unique genes, relative to the other three <jats:italic>L. chiayiensis<\/jats:italic> strains. Among them, the presence of genes such as <jats:italic>clpP<\/jats:italic>, <jats:italic>pepO<\/jats:italic>, and <jats:italic>feoA<\/jats:italic> suggests a possible advantage of AACE3 over other <jats:italic>L. chiayiensis<\/jats:italic> in terms of environmental adaptation. <jats:italic>In vitro<\/jats:italic> evaluation of the properties revealed that AACE3 had robust antibacterial activity against eight common pathogens: <jats:italic>Streptococcus agalactiae<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Salmonella enteritidis<\/jats:italic>, <jats:italic>Salmonella choleraesuis<\/jats:italic>, <jats:italic>Shigella flexneri<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Klebsiella pneumoniae<\/jats:italic>. In addition, AACE3 showed more than 80% survival rate in all tests simulating gastrointestinal fluid, and it exhibited high antioxidant capacity. Interestingly, the cell culture supernatant was superior to intact organisms and ultrasonically crushed bacterial extracts in all tests of antioxidant capacity. These results suggested that the antioxidant capacity may originate from certain metabolites and extracellular enzymes produced by AACE3. Moreover, AACE3 was a moderate biofilm producer due to the self-agglomeration effect. Taken together, <jats:italic>L. chiayiensis<\/jats:italic> AACE3 appears to be a candidate strain for combating the growing incidence of pathogen infections and antioxidant production.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1168378","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:10:55Z","timestamp":1684473055000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Genomic and in-vitro characteristics of a novel strain Lacticaseibacillus chiayiensis AACE3 isolated from fermented blueberry"],"prefix":"10.3389","volume":"14","author":[{"given":"Xin-Dong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Si","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Gang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Bing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/5584_2020_495","article-title":"Ability of three lactic acid Bacteria to grow in sessile mode and to inhibit biofilm formation of pathogenic Bacteria","volume":"1282","author":"Benmouna","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1093\/gbe\/evv148","article-title":"A model of genome size evolution for prokaryotes in stable and fluctuating environments","volume":"7","author":"Bentkowski","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10534-006-0003-2","article-title":"Feo\u2013transport of ferrous iron into bacteria","volume":"19","author":"Cartron","year":"2006","journal-title":"Biometals"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"27670","DOI":"10.1016\/s0021-9258(18)47038-x","article-title":"Thioredoxin-dependent peroxide reductase from yeast","volume":"269","author":"Chae","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep24373","article-title":"BPGA-an ultra-fast pan-genome analysis pipeline","volume":"6","author":"Chaudhari","year":"2016","journal-title":"Sci. Rep."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1574-6968.2000.tb09322.x","article-title":"Purification, characterisation, cloning and sequencing of the gene encoding oligopeptidase PepO from Streptococcus thermophilus a","volume":"191","author":"Chavagnat","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.fm.2013.11.008","article-title":"Development of an alternative culture medium for the selective enumeration of Lactobacillus casei in fermented milk","volume":"39","author":"Colombo","year":"2014","journal-title":"Food Microbiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/ja.2016.138","article-title":"Bacterial proteases, untapped antimicrobial drug targets","volume":"70","author":"Culp","year":"2017","journal-title":"J. Antibiot."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.biotechadv.2018.09.003","article-title":"How to select a probiotic? A review and update of methods and criteria","volume":"36","author":"de Melo Pereira","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3390\/microorganisms11020313","article-title":"Adaptation of Lacticaseibacillus rhamnosus CM MSU 529 to aerobic growth: a proteomic approach","volume":"11","author":"Dinarieva","year":"2023","journal-title":"Microorganisms"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"135155","DOI":"10.1016\/j.foodchem.2022.135155","article-title":"Improving flavor, bioactivity, and changing metabolic profiles of goji juice by selected lactic acid bacteria fermentation","volume":"408","author":"Duan","year":"2023","journal-title":"Food Chem."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1093\/femsre\/fux030","article-title":"Lifestyles in transition: evolution and natural history of the genus Lactobacillus","volume":"41","author":"Duar","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.fm.2019.01.004","article-title":"Transcriptional profiling and metabolomic analysis of Staphylococcus aureus grown on autoclaved chicken breast","volume":"82","author":"Dupre","year":"2019","journal-title":"Food Microbiol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/1471-0307.12428","article-title":"Antioxidant activity, functional properties and bioaccessibility of whey protein hydrolysates","volume":"71","author":"Embiriekah","year":"2018","journal-title":"Int. J. Dairy Technol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"112439","DOI":"10.1016\/j.lwt.2021.112439","article-title":"In vitro evaluation of the synbiotic effect of probiotic Lactobacillus strains and garlic extract against Salmonella species","volume":"153","author":"Fadare","year":"2022","journal-title":"LWT"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"D261","DOI":"10.1093\/nar\/gku1223","article-title":"Expanded microbial genome coverage and improved protein family annotation in the COG database","volume":"43","author":"Galperin","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12263-011-0229-7","article-title":"Intestinal microbiota in human health and disease: the impact of probiotics","volume":"6","author":"Gerritsen","year":"2011","journal-title":"Genes Nutr."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fmolb.2017.00034","article-title":"Multifunctional mitochondrial AAA proteases","volume":"4","author":"Glynn","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1051\/lait:1998547","article-title":"Streptococcus thermophilus as adjunct culture for a semi-hard cows' milk cheese","volume":"78","author":"Gomez","year":"1998","journal-title":"Lait"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/B978-0-12-802304-4.00004-9","article-title":"Value of microbial genome sequencing for probiotic strain identification and characterization: promises and pitfalls","author":"Guinane","year":"2016","journal-title":"Gut Brain Axis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"fnv047","DOI":"10.1093\/femsle\/fnv047","article-title":"Change in cell surface properties of Lactobacillus casei under heat shock treatment","volume":"362","author":"Haddaji","year":"2015","journal-title":"FEMS Microbiol. Lett."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"4542","DOI":"10.1128\/AEM.02264-09","article-title":"Enterocin X, a novel two-peptide Bacteriocin from Enterococcus faecium KU-B5, has an antibacterial Spectrum entirely different from those of its component peptides","volume":"76","author":"Hu","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.syapm.2018.01.008","article-title":"Polyphasic characterization of a novel species in the Lactobacillus casei group from cow manure of Taiwan: description of L. chiayiensis sp. nov","volume":"41","author":"Huang","year":"2018","journal-title":"Syst. Appl. Microbiol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat. Commun."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"145985","DOI":"10.1016\/j.gene.2021.145985","article-title":"Comparative genomic analysis reveals the evolution and environmental adaptation of Acinetobacter johnsonii","volume":"808","author":"Jia","year":"2022","journal-title":"Gene"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s00203-022-02957-z","article-title":"Reactive oxygen species accumulation is synchronised with growth inhibition of temperature-sensitive recAts polA Escherichia coli","volume":"204","author":"Kaidow","year":"2022","journal-title":"Arch. Microbiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1128\/jb.175.19.6212-6219.1993","article-title":"Characterization of the ferrous iron uptake system of Escherichia coli","volume":"175","author":"Kammler","year":"1993","journal-title":"J. Bacteriol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e0175541","DOI":"10.1371\/journal.pone.0175541","article-title":"An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony","volume":"12","author":"Kant","year":"2017","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1006\/fmic.2001.0420","article-title":"Inhibition of Listeria monocytogenes in cold smoked salmon by addition of sakacin P and\/or live Lactobacillus sakei cultures","volume":"18","author":"Katla","year":"2001","journal-title":"Food Microbiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e8099","DOI":"10.1371\/journal.pone.0008099","article-title":"Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum","volume":"4","author":"Kaushik","year":"2009","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"794315","DOI":"10.3389\/fmicb.2021.794315","article-title":"Complete genome sequencing and comparative genomics of three potential probiotic strains, Lacticaseibacillus casei FBL6, Lacticaseibacillus chiayiensis FBL7, and Lacticaseibacillus zeae FBL8","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/nutrit\/nuy056","article-title":"Yogurt and other fermented foods as sources of health-promoting bacteria","volume":"76","author":"Kok","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1073\/pnas.0409727102","article-title":"Genomic insights that advance the species definition for prokaryotes","volume":"102","author":"Konstantinidis","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1093\/nar\/gkm160","article-title":"RNAmmer: consistent and rapid annotation of ribosomal RNA genes","volume":"35","author":"Lagesen","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/nar\/gkh152","article-title":"ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences","volume":"32","author":"Laslett","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.mib.2005.08.005","article-title":"Genome evolution in bacteria: order beneath chaos","volume":"8","author":"Lawrence","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/toxins9100301","article-title":"Safety assessment of Lactobacillus helveticus KLDS1.8701 based on whole genome sequencing and Oral toxicity studies","volume":"9","author":"Li","year":"2017","journal-title":"Toxins"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.foodchem.2012.06.048","article-title":"Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods","volume":"135","author":"Li","year":"2012","journal-title":"Food Chem."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1021\/jf981149l","article-title":"Antioxidative ability of lactic acid bacteria","volume":"47","author":"Lin","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1002\/jsfa.4456","article-title":"Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides","volume":"91","author":"Liu","year":"2011","journal-title":"J. Sci. Food Agric."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/j.fm.2011.06.007","article-title":"Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion","volume":"28","author":"Lo Curto","year":"2011","journal-title":"Food Microbiol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e59798","DOI":"10.5812\/jjm.17523","article-title":"Characterization of indigenous Lactobacillus strains for probiotic properties","volume":"8","author":"Mojgani","year":"2015","journal-title":"Jundishapur J. Microbiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"6463","DOI":"10.1007\/s00253-019-09978-7","article-title":"Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health","volume":"103","author":"Monteagudo Mera","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1128\/AEM.69.5.2975-2984.2003","article-title":"Enterolysin a, a Cell Wall-degrading Bacteriocin from Enterococcus faecalis LMG 2333","volume":"69","author":"Nilsen","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3136\/nskkk1962.35.11_771","article-title":"Antioxidative activities of browning products of glucosamine fractionated by organic solvent and thin-layer chromatography","volume":"35","author":"Oyaizu","year":"1988","journal-title":"Nippon Shokuhin Kogyo Gakkaishi"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e02572","DOI":"10.1128\/spectrum.02572-22","article-title":"The role ofluxSin Campylobacter jejuni beyond intercellular signaling","volume":"11","author":"Rami\u0107","year":"2023","journal-title":"Microbiol Spectr."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10529-018-02637-3","article-title":"Thermophilin 109 is a naturally produced broad spectrum bacteriocin encoded within the blp gene cluster of Streptococcus thermophilus","volume":"41","author":"Renye","year":"2019","journal-title":"Biotechnol. Lett."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1080\/09168451.2019.1584522","article-title":"Aggregation of Lactobacillus brevis associated with decrease in pH by glucose fermentation","volume":"83","author":"Saito","year":"2019","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4161\/gmic.1.3.12127","article-title":"Safety assessment of probiotics for human use","volume":"1","author":"Sanders","year":"2010","journal-title":"Gut Microbes"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1146\/annurev-biochem-060408-172623","article-title":"AAA+ proteases: ATP-fueled machines of protein destruction","volume":"80","author":"Sauer","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fsufs.2023.1072738","article-title":"Utilization of novel bacteriocin synthesized silver nanoparticles (AgNPs) for their application in antimicrobial packaging for preservation of tomato fruit","volume":"7","author":"Sharma","year":"2023","journal-title":"Front. Sustain. Food Syst."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/AEM.69.1.1-9.2003","article-title":"A postgenomic appraisal of osmotolerance in Listeria monocytogenes","volume":"69","author":"Sleator","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e00179","DOI":"10.1128\/mBio.00179-11","article-title":"Conserved mutations in the pneumococcal Bacteriocin transporter gene, blpA, result in a complex population consisting of producers and cheaters","volume":"2","author":"Son","year":"2011","journal-title":"MBio"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1099\/00207713-44-4-846","article-title":"Taxonomic note: a place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology","volume":"44","author":"Stackebrandt","year":"1994","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref57","first-page":"815","article-title":"Assessment of potential probiotic bacteria isolated from milk of domestic animals","volume":"15","author":"Tambekar","year":"2009","journal-title":"J. Appl. Biosci."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cphy.c190007","article-title":"Intestinal absorption of bile acids in health and disease","volume":"10","author":"Ticho","year":"2019","journal-title":"Compr. Physiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1099\/ijs.0.2008\/005330-0","article-title":"The type strain of Lactobacillus casei is ATCC 393, ATCC 334 cannot serve as the type because it represents a different taxon, the name Lactobacillus paracasei and its subspecies names are not rejected and the revival of the name 'Lactobacillus zeae' contravenes rules 51b (1) and (2) of the international code of nomenclature of Bacteria Opinion 82","volume":"58","author":"Tindall","year":"2008","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"W278","DOI":"10.1093\/nar\/gky383","article-title":"BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins","volume":"46","author":"van Heel","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.foodres.2019.06.001","article-title":"Probiotic Prato cheese attenuates cigarette smoke-induced injuries in mice","volume":"123","author":"Vasconcelos","year":"2019","journal-title":"Food Res. Int."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.syapm.2005.02.011","article-title":"DNA-based classification and sequence heterogeneities in the 16S rRNA genes of Lactobacillus casei\/paracasei and related species","volume":"28","author":"V\u00e1squez","year":"2005","journal-title":"Syst. Appl. Microbiol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ijfoodmicro.2006.01.029","article-title":"Lactobacillus spp. with in vitro probiotic properties from human faeces and traditional fermented products","volume":"109","author":"Vizoso Pinto","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.foodcont.2009.04.007","article-title":"Antifungal activity of non-starter lactic acid bacteria isolates from dairy products","volume":"21","author":"Voulgari","year":"2010","journal-title":"Food Control"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1111\/j.1462-2920.2007.01292.x","article-title":"D-Alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract","volume":"9","author":"Walter","year":"2007","journal-title":"Environ. Microbiol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"193","DOI":"10.13802\/j.cnki.zwbhxb.2016.02.003","article-title":"Functional analysis of quorum sensing regulator ComA on the production of antifungal active compounds and biofilm formation in Bacillus subtilis NCD-2","volume":"43","author":"Wang","year":"2016","journal-title":"Acta Phytophylacica Sinica"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1007\/s00253-016-8032-4","article-title":"Bacillus amyloliquefaciens SC06 alleviates the oxidative stress of IPEC-1 via modulating Nrf2\/Keap1 signaling pathway and decreasing ROS production","volume":"101","author":"Wang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1128\/AEM.68.3.1196-1203.2002","article-title":"Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans","volume":"68","author":"Wen","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pcbi.1005595","article-title":"Unicycler: resolving bacterial genome assemblies from short and long sequencing reads","volume":"13","author":"Wick","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijbiomac.2021.11.136","article-title":"Antibacterial effect of bacteriocin XJS01 and its application as antibiofilm agents to treat multidrug-resistant Staphylococcus aureus infection","volume":"196","author":"Xiang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/pathogens4010034","article-title":"The use of lactic acid Bacteria as a probiotic in swine diets","volume":"4","author":"Yang","year":"2015","journal-title":"Pathogens"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3382\/ps.2013-03314","article-title":"Effects of multistrain probiotics on growth performance, apparent ileal nutrient digestibility, blood characteristics, cecal microbial shedding, and excreta odor contents in broilers","volume":"93","author":"Zhang","year":"2014","journal-title":"Poult. Sci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"918774","DOI":"10.3389\/fmicb.2022.918774","article-title":"Screening and evaluation of lactic acid bacteria with probiotic potential from local Holstein raw milk","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"756519","DOI":"10.3389\/fmicb.2021.756519","article-title":"Identification, characterization, and antioxidant potential of Bifidobacterium longum subsp. longum strains isolated from feces of healthy infants","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3390\/antibiotics11101426","article-title":"CcpA regulates Staphylococcus aureus biofilm formation through direct repression of Staphylokinase expression","volume":"11","author":"Zheng","year":"2022","journal-title":"Antibiotics"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2023.1168378\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:11:02Z","timestamp":1684473062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2023.1168378\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":75,"alternative-id":["10.3389\/fmicb.2023.1168378"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2023.1168378","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"article-number":"1168378"}}