{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:39:21Z","timestamp":1790627961793,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The airways of people with cystic fibrosis (<jats:italic>CF<\/jats:italic>) often harbor a diverse microbiota and in recent years, much effort has been invested in cataloguing these. In spite of providing a wealth of insight, this cataloguing tells us little about how the organisms interact with one another in the <jats:italic>CF<\/jats:italic> airways. However, such relationships can be inferred using the theoretical framework of the Lotka-Volterra (LV) model. In the current work, we use a generalized Lotka-Volterra model to interrogate the nationwide data collected and curated by the UK <jats:italic>CF<\/jats:italic> Registry. This longitudinal dataset (covering the period 2008\u20132020) contains annual depositions that record the presence\/absence of microbial taxa in each patient, their medication, and their <jats:italic>CF<\/jats:italic> genotype. Specifically, we wanted to identify trends in ecological relationships between the <jats:italic>CF<\/jats:italic> microbiota at a nationwide level, and whether these are potentially affected by medication. Our results show that some medications have a distinct influence on the microbial interactome, especially those that potentially influence the \u201cgut-lung axis\u201d or mucus viscosity. In particular, we found that patients treated with a combination of antimicrobial agents (targeting the airway microbiota), digestive enzymes (assisting in the assimilation of dietary fats and carbohydrates), and DNase (to reduce mucus viscosity) displayed a distinctly different airway interactome compared with patients treated separately with these medications.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1178131","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T10:17:55Z","timestamp":1685528275000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic interventions alter ecological interactions among cystic fibrosis airway microbiota"],"prefix":"10.3389","volume":"14","author":[{"given":"Pok-Man","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahan Rudland","family":"Nazeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1055\/s-0039-1696726","article-title":"Growth and nutrition in cystic fibrosis","volume":"40","author":"Brownell","year":"2019","journal-title":"Semin. 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