{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:30:24Z","timestamp":1790886624842,"version":"4.1.0"},"reference-count":236,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The aquatic bacterium <jats:italic>Vibrio cholerae<\/jats:italic> is the etiological agent of the diarrheal disease cholera, which has plagued the world for centuries. This pathogen has been the subject of studies in a vast array of fields, from molecular biology to animal models for virulence activity to epidemiological disease transmission modeling. <jats:italic>V. cholerae<\/jats:italic> genetics and the activity of virulence genes determine the pathogenic potential of different strains, as well as provide a model for genomic evolution in the natural environment. While animal models for <jats:italic>V. cholerae<\/jats:italic> infection have been used for decades, recent advances in this area provide a well-rounded picture of nearly all aspects of <jats:italic>V. cholerae<\/jats:italic> interaction with both mammalian and non-mammalian hosts, encompassing colonization dynamics, pathogenesis, immunological responses, and transmission to na\u00efve populations. Microbiome studies have become increasingly common as access and affordability of sequencing has improved, and these studies have revealed key factors in <jats:italic>V. cholerae<\/jats:italic> communication and competition with members of the gut microbiota. Despite a wealth of knowledge surrounding <jats:italic>V. cholerae<\/jats:italic>, the pathogen remains endemic in numerous countries and causes sporadic outbreaks elsewhere. Public health initiatives aim to prevent cholera outbreaks and provide prompt, effective relief in cases where prevention is not feasible. In this review, we describe recent advancements in cholera research in these areas to provide a more complete illustration of <jats:italic>V. cholerae<\/jats:italic> evolution as a microbe and significant global health threat, as well as how researchers are working to improve understanding and minimize impact of this pathogen on vulnerable populations.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1178538","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T04:30:02Z","timestamp":1684729802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Advances in cholera research: from molecular biology to public health initiatives"],"prefix":"10.3389","volume":"14","author":[{"given":"Madison G.","family":"Walton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Cubillejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhrubajyoti","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Withey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nmeth.3253","article-title":"Sequence tag-based analysis of microbial population dynamics","volume":"12","author":"Abel","year":"2015","journal-title":"Nat. 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Lett."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"6674","DOI":"10.1128\/IAI.73.10.6674-6679.2005","article-title":"Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse","volume":"73","author":"Alam","year":"2005","journal-title":"Infect. Immun."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.cell.2020.05.036","article-title":"Interpersonal gut microbiome variation drives susceptibility and resistance to cholera infection","volume":"181","author":"Alavi","year":"2020","journal-title":"Cells"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0003832","DOI":"10.1371\/journal.pntd.0003832","article-title":"Updated global burden of cholera in endemic countries","volume":"9","author":"Ali","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e0183100","DOI":"10.1371\/journal.pone.0183100","article-title":"Identification of burden hotspots and risk factors for cholera in India: an observational study","volume":"12","author":"Ali","year":"2017","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.epidem.2015.08.001","article-title":"High-resolution spatial analysis of cholera patients reported in Artibonite department, Haiti in 2010\u20132011","volume":"14","author":"Allan","year":"2016","journal-title":"Epidemics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e1004787","DOI":"10.1371\/journal.ppat.1004787","article-title":"Intestinal colonization dynamics of Vibrio cholerae","volume":"11","author":"Almagro-Moreno","year":"2015","journal-title":"PLoS Pathog."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1128\/IAI.67.8.3733-3739.1999","article-title":"Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection","volume":"67","author":"Angelichio","year":"1999","journal-title":"Infect. Immun."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e0004031","DOI":"10.1371\/journal.pntd.0004031","article-title":"Bile salts modulate the mucin-activated type VI secretion system of pandemic Vibrio cholerae","volume":"9","author":"Bachmann","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e03339","DOI":"10.1128\/mBio.03339-19","article-title":"Genome dynamics of Vibrio cholerae isolates linked to seasonal outbreaks of cholera in Dhaka, Bangladesh","volume":"11","author":"Baddam","year":"2020","journal-title":"mBio"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3389\/fmicb.2020.00825","article-title":"Cholera toxin production in Vibrio cholerae O1 El tor biotype strains in single-phase culture","volume":"11","author":"Baek","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/s0140-6736(74)92233-8","article-title":"Epidemiology of cholera in Italy in 1973","volume":"2","author":"Baine","year":"1974","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1128\/aem.62.10.3673-3678.1996","article-title":"Genetic transformation in freshwater: Escherichia coli is able to develop natural competence","volume":"62","author":"Baur","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e0044121","DOI":"10.1128\/IAI.00441-21","article-title":"Bile salts promote ToxR regulon activation during growth under virulence-inducing conditions","volume":"89","author":"Bina","year":"2021","journal-title":"Infect. Immun."},{"key":"ref19","first-page":"291","article-title":"Historical perspectives on pandemic cholera","volume-title":"Vibrio cholerae and cholera","author":"Blake","year":"1994"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1371\/journal.ppat.0010008","article-title":"Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera","volume":"1","author":"Blow","year":"2005","journal-title":"PLoS Pathog."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2017.07.019","article-title":"Galleria mellonella is low cost and suitable surrogate host for studying virulence of human pathogenic Vibrio cholerae","volume":"628","author":"Bokhari","year":"2017","journal-title":"Gene"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0015721","DOI":"10.1128\/iai.00157-21","article-title":"Vibrio cholerae infection induces strain specific modulation of the zebrafish intestinal microbiome","volume":"89","author":"Breen","year":"","journal-title":"Infect. Immun."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e0015121","DOI":"10.1128\/IAI.00151-21","article-title":"The Vibrio cholerae type six secretion system is dispensable for colonization but affects pathogenesis and the structure of zebrafish intestinal microbiome","volume":"89","author":"Breen","year":"","journal-title":"Infect. Immun."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e65487","DOI":"10.7554\/eLife.65487","article-title":"Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals","volume":"10","author":"Bridges","year":"2021","journal-title":"Elife"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/infdis\/116.2.183","article-title":"Cholera infection and toxin in the rabbit ileal loop","volume":"116","author":"Burrows","year":"1966","journal-title":"J. Infect. Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"5018","DOI":"10.1073\/pnas.0308052101","article-title":"Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae","volume":"101","author":"Butler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrmicro1207","article-title":"Going against the grain: chemotaxis and infection in Vibrio cholerae","volume":"3","author":"Butler","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1365-2958.2006.05096.x","article-title":"Cholera stool bacteria repress chemotaxis to increase infectivity","volume":"60","author":"Butler","year":"2006","journal-title":"Mol. Microbiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e03380-20","DOI":"10.1128\/mBio.03380-20","article-title":"Regulatory effects of CsrA in Vibrio cholerae","volume":"12","author":"Butz","year":"2021","journal-title":"MBio"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e680","DOI":"10.1016\/S2214-109X(18)30230-4","article-title":"Cholera epidemic in Yemen, 2016-18: an analysis of surveillance data","volume":"6","author":"Camacho","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"8736","DOI":"10.1073\/pnas.0803281105","article-title":"A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae","volume":"105","author":"Cameron","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref32","volume-title":"Sources of infection and risk factors","year":"2020"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"9033","DOI":"10.1093\/nar\/gkt654","article-title":"High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data","volume":"41","author":"Chao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e0120311","DOI":"10.1371\/journal.pone.0120311","article-title":"Scanning the landscape of genome architecture of non-O1 and non-O139 Vibrio cholerae by whole genome mapping reveals extensive population genetic diversity","volume":"10","author":"Chapman","year":"2015","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/B978-0-7020-4089-4.00045-7","article-title":"Vibrio, mobiluncus, gardnerella and spirillum: Cholera; vaginosis; rat bite fever","volume-title":"Medical microbiology","author":"Chart","year":"2012"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1128\/IAI.01435-06","article-title":"Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae","volume":"75","author":"Chatterjee","year":"2007","journal-title":"Infect. Immun."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e2121180119","DOI":"10.1073\/pnas.2121180119","article-title":"A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e0264443","DOI":"10.1371\/journal.pone.0264443","article-title":"Ranking the biases: the choice of OTUs vs. ASVs in 16S rRNA amplicon data analysis has stronger effects on diversity measures than rarefaction and OTU identity threshold","volume":"17","author":"Chiarello","year":"2022","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1056\/NEJMoa1012928","article-title":"The origin of the Haitian cholera outbreak strain","volume":"364","author":"Chin","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.mib.2017.01.002","article-title":"The ins and outs of cyclic di-GMP signaling in Vibrio cholerae","volume":"36","author":"Conner","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref41","first-page":"119","article-title":"Cholera and climate: a demonstrated relationship","volume":"120","author":"Constantin de Magny","year":"2009","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-4939-8685-9_2","article-title":"Genotypic and phenotypic assays to distinguish Vibrio cholerae biotype","volume-title":"Vibrio Cholerae: methods and protocols","author":"Crumfield","year":"2018"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e00381","DOI":"10.1128\/mBio.00381-15","article-title":"Gut microbial succession follows acute secretory diarrhea in humans","volume":"6","author":"David","year":"2015","journal-title":"MBio"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.3389\/fimmu.2019.03128","article-title":"Host-microbe-pathogen interactions: a review of Vibrio cholerae pathogenesis in drosophila","volume":"10","author":"Davoodi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1371\/journal.pntd.0000173","article-title":"The high burden of cholera in children: comparison of incidence from endemic areas in Asia and Africa","volume":"2","author":"Deen","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/s0950-3528(97)90029-4","article-title":"Oral rehydration solution in the year 2000: pathophysiology, efficacy and effectiveness","volume":"11","author":"Desjeux","year":"1997","journal-title":"Baillieres Clin. Gastroenterol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.aao2136","article-title":"Integrated view of Vibrio cholerae in the Americas","volume":"358","author":"Domman","year":"2017","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3390\/toxins13050346","article-title":"Shining a light on colibactin biology","volume":"13","author":"Dougherty","year":"2021","journal-title":"Toxins (Basel)"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/fcimb.2019.00131","article-title":"Vibrio flagellar synthesis","volume":"9","author":"Echazarreta","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0303-2647(93)90050-M","article-title":"Algal blooms in the spread and persistence of cholera","volume":"31","author":"Epstein","year":"1993","journal-title":"Biosystems"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.1206025","article-title":"Predicting a human gut microbiota\u2019s response to diet in gnotobiotic mice","volume":"333","author":"Faith","year":"2011","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1128\/IAI.01377-13","article-title":"Enhanced interaction of Vibrio cholerae virulence regulators TcpP and ToxR under oxygen-limiting conditions","volume":"82","author":"Fan","year":"2014","journal-title":"Infect. Immun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e0046621","DOI":"10.1128\/iai.00466-21","article-title":"Neutrophil-associated responses to Vibrio cholerae infection in a natural host model","volume":"90","author":"Farr","year":"2022","journal-title":"Infect. Immun."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"722520","DOI":"10.3389\/fcimb.2021.722520","article-title":"Characterization of the immune response to Vibrio cholerae infection in a natural host model","volume":"11","author":"Farr","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"6350","DOI":"10.1073\/pnas.0601277103","article-title":"Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environment","volume":"103","author":"Faruque","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.celrep.2019.12.094","article-title":"Vibrio cholerae-symbiont interactions inhibit intestinal repair in drosophila","volume":"30","author":"Fast","year":"2020","journal-title":"Cell Rep."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e00790-19","DOI":"10.1128\/mBio.00790-19","article-title":"A Vibrio cholerae BolA-like protein is required for proper cell shape and cell envelope integrity","volume":"10","author":"Fleurie","year":"2019","journal-title":"MBio"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"E158","DOI":"10.1111\/j.1469-0691.2012.03841.x","article-title":"Nepalese origin of cholera epidemic in Haiti","volume":"18","author":"Frerichs","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.chom.2013.11.001","article-title":"Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host","volume":"14","author":"Fu","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"11010","DOI":"10.1073\/pnas.1916571117","article-title":"Upregulation of virulence genes promotes Vibrio cholerae biofilm hyperinfectivity","volume":"117","author":"Gallego-Hernandez","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"A13","DOI":"10.1016\/j.vaccine.2019.07.036","article-title":"Cholera surveillance and estimation of burden of cholera","volume":"38","author":"Ganesan","year":"2020","journal-title":"Vaccine"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fmicb.2019.00111","article-title":"Haitian variant Vibrio cholerae O1 strains manifest higher virulence in animal models","volume":"10","author":"Ghosh","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.gde.2015.10.003","article-title":"Microbial diversity--exploration of natural ecosystems and microbiomes","volume":"35","author":"Gibbons","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4122","DOI":"10.1128\/IAI.00566-10","article-title":"Identification of the TcpP-binding site in the toxT promoter of vibrio cholerae and the role of ToxR in TcpP-mediated activation","volume":"78","author":"Goss","year":"2010","journal-title":"Infect. Immun."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.diagmicrobio.2017.11.017","article-title":"A real-time multiplex PCR for the identification and typing of Vibrio cholerae","volume":"90","author":"Greig","year":"2018","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e0129321","DOI":"10.1128\/AEM.01293-21","article-title":"Vibrio cholerae motility in aquatic and mucus-mimicking environments","volume":"87","author":"Grognot","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"ref69","volume-title":"Ending cholera\u2014a global roadmap to 2030","year":"2017"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/mmi.12834","article-title":"Single-molecule tracking in live Vibrio cholerae reveals that ToxR recruits the membrane-bound virulence regulator TcpP to the toxT promoter","volume":"96","author":"Haas","year":"2015","journal-title":"Mol. Microbiol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1128\/JB.00353-13","article-title":"The function of the Na+\u2212driven flagellum of Vibrio cholerae is determined by osmolality and pH","volume":"195","author":"Halang","year":"2013","journal-title":"J. Bacteriol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fmicb.2017.00282","article-title":"Fish as hosts of Vibrio cholerae","volume":"8","author":"Halpern","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.chom.2014.10.006","article-title":"The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism","volume":"16","author":"Hang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/mdr.2016.0087","article-title":"Biofilms: microbial shelters against antibiotics","volume":"23","author":"Hathroubi","year":"2017","journal-title":"Microb. 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Res."},{"key":"ref150","doi-asserted-by":"publisher","first-page":"19091","DOI":"10.1073\/pnas.0706352104","article-title":"Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea","volume":"104","author":"Nelson","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref151","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1371\/journal.ppat.0020109","article-title":"RpoS controls the Vibrio cholerae mucosal escape response","volume":"2","author":"Nielsen","year":"2006","journal-title":"PLoS Pathog."},{"key":"ref152","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s12088-016-0592-6","article-title":"Role of indole production on virulence of Vibrio cholerae using galleria mellonella larvae model","volume":"56","author":"Nuidate","year":"2016","journal-title":"Indian J. Microbiol."},{"key":"ref153","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1128\/IAI.01197-08","article-title":"Establishment of an adult mouse model for direct evaluation of the efficacy of vaccines against Vibrio cholerae","volume":"77","author":"Nygren","year":"2009","journal-title":"Infect. 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A."},{"key":"ref208","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1038\/ncomms4549","article-title":"The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition","volume":"5","author":"Unterweger","year":"2014","journal-title":"Nat. Commun."},{"key":"ref209","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1038\/ncomms5913","article-title":"Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment","volume":"5","author":"Utada","year":"2014","journal-title":"Nat. Commun."},{"key":"ref210","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1073\/pnas.0601754103","article-title":"A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing","volume":"103","author":"Vaitkevicius","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. 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