{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:04:10Z","timestamp":1790744650005,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Periodontitis is an inflammatory disease initiated by periodontopathogenic bacteria in the dental plaque biofilms. Understanding the role of\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    ), a keystone pathogen associated with chronic periodontitis, in the inflammatory response is crucial. Herein, we investigated whether\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    infection triggers the expression of the type I IFN gene and various cytokines and leads to activation of the cGAMP synthase\u2013stimulator of IFN genes (cGAS-STING) pathway both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in a mouse model. Additionally, in an experimental model of periodontitis using\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    , Sting\n                    <jats:sup>Gt<\/jats:sup>\n                    mice showed lower levels of inflammatory cytokines and bone resorption than wild-type mice. Furthermore, we report that a STING inhibitor (SN-011) significantly decreased inflammatory cytokine production and osteoclast formation in a periodontitis mouse model with\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    . In addition, STING agonist (SR-717) -treated periodontitis mice displayed enhanced macrophage infiltration and M1 macrophage polarization in periodontal lesions compared with that in vehicle-treated periodontitis mice. In conclusion, our results demonstrate that the cGAS-STING signaling pathway may be one of the key mechanisms crucial for the\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    -induced inflammatory response that leads to chronic periodontitis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2023.1183415","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T03:59:18Z","timestamp":1687147158000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model"],"prefix":"10.3389","volume":"14","author":[{"given":"Rong","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00109-016-1423-2","article-title":"The role of cGAS in innate immunity and beyond","volume":"94","author":"Ablasser","year":"2016","journal-title":"J. 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