{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:09:59Z","timestamp":1782868199644,"version":"3.54.5"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The escalating incidence of Crohn\u2019s disease (CD), a debilitating ailment that ravages individuals and their families, has become a formidable issue over recent decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, fecal samples from patients with CD and healthy individuals were investigated by means of viral metagenomics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fecal virome was analyzed and some suspected disease-causing viruses were described. A polyomavirus named HuPyV with 5,120 base pairs (bp) was found in the disease group. In a preliminary analysis employing large T region-specific primers, it was found that HuPyV was present in 3.2% (1\/31) of healthy samples and 43.2% (16\/37) of disease samples. Additionally, two other viruses from the anellovirus and CRESS-DNA virus families were found in fecal samples from CD patients. The complete genome sequences of these two viruses were described respectively, and the phylogenetic trees have been built using the anticipated amino acid sequences of the viral proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Further research is required to elucidate the relationship between these viruses and the onset and development of Crohn\u2019s disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2023.1190172","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T04:41:21Z","timestamp":1686804081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the gut virus communities between patients with Crohn\u2019s disease and healthy individuals"],"prefix":"10.3389","volume":"14","author":[{"given":"Yuzhu","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.chom.2019.04.001","article-title":"Redondoviridae, a family of small, circular DNA viruses of the human Oro-respiratory tract associated with periodontitis and critical illness","volume":"25","author":"Abbas","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2020.01.007","article-title":"The role of lung and gut microbiota in the pathology of asthma","volume":"52","author":"Barcik","year":"2020","journal-title":"Immunity"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1016\/j.cgh.2015.05.022","article-title":"Prevalence of antibodies against JC virus in patients with refractory Crohn's disease and effects of Natalizumab therapy","volume":"13","author":"Bellaguarda","year":"2015","journal-title":"Clin. 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