{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:05:55Z","timestamp":1793300755382,"version":"4.5.0"},"reference-count":375,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    is one of the most common opportunistic human pathogens causing several infectious diseases. Ever since the emergence of the first methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) strain decades back, the organism has been a major cause of hospital-acquired infections (HA-MRSA). The spread of this pathogen across the community led to the emergence of a more virulent subtype of the strain, i.e., Community acquired Methicillin resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (CA-MRSA). Hence, WHO has declared\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    as a high-priority pathogen. MRSA pathogenesis is remarkable because of the ability of this \u201csuperbug\u201d to form robust biofilm both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    by the formation of polysaccharide intercellular adhesin (PIA), extracellular DNA (eDNA), wall teichoic acids (WTAs), and capsule (CP), which are major components that impart stability to a biofilm. On the other hand, secretion of a diverse array of virulence factors such as hemolysins, leukotoxins, enterotoxins, and Protein A regulated by\n                    <jats:italic>agr<\/jats:italic>\n                    and\n                    <jats:italic>sae<\/jats:italic>\n                    two-component systems (TCS) aids in combating host immune response. The up- and downregulation of adhesion genes involved in biofilm formation and genes responsible for synthesizing virulence factors during different stages of infection act as a genetic regulatory see-saw in the pathogenesis of MRSA. This review provides insight into the evolution and pathogenesis of MRSA infections with a focus on genetic regulation of biofilm formation and virulence factors secretion.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2023.1204428","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T23:55:15Z","timestamp":1687564515000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":65,"title":["A genetic regulatory see-saw of biofilm and virulence in MRSA pathogenesis"],"prefix":"10.3389","volume":"14","author":[{"given":"Hardi","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nature11724","article-title":"CCR5 is a receptor for Staphylococcus aureus leukotoxin ED","volume":"493","author":"Alonzo III","year":"2013","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1128\/MMBR.00055-13","article-title":"The bicomponent pore-forming leucocidins of Staphylococcus aureus","volume":"78","author":"Alonzo III","year":"2014","journal-title":"Microbiol. 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