{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:53:03Z","timestamp":1784749983458,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Enterococcus faecalis<\/jats:italic> is a well-established resident of the human gastrointestinal tract and is also a major cause of human infections. Unfortunately, therapeutic options for <jats:italic>E. faecalis<\/jats:italic> infections remain limited, particularly with the emergence of vancomycin-resistant strains in hospital settings. Consequently, there has been a renewed interest in phage therapy as an alternative to antibiotics. In this study, we have isolated a bacteriophage, vB_EfaS-SFQ1, from hospital sewage, which effectively infects <jats:italic>E. faecalis<\/jats:italic> strain EFS01. Phage SFQ1 is a siphovirus and exhibits a relatively broad host range. Furthermore, it has a short latent period of approximately 10\u2009min and a large burst size of about 110 PFU\/cell at a multiplicity of infection (MOI) of 0.01, and it could effectively disrupt the biofilms formed by <jats:italic>E. faecalis<\/jats:italic>. Thus, this study provides a detailed characterization of <jats:italic>E. faecalis<\/jats:italic> phage SFQ1, which has great potential for treating <jats:italic>E. faecalis<\/jats:italic> infections.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1210319","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T04:17:30Z","timestamp":1687580250000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of an Enterococcus faecalis bacteriophage SFQ1 as a potential therapeutic agent"],"prefix":"10.3389","volume":"14","author":[{"given":"Fuqiang","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1002\/ptr.7488","article-title":"Antibiofilm activity of phytochemicals against Enterococcus faecalis: a literature review","volume":"36","author":"Ali","year":"2022","journal-title":"Phytother. 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