{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:44:21Z","timestamp":1792295061094,"version":"4.4.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0288"],"award-info":[{"award-number":["2023YFS0288"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Portal vein thrombosis (PVT) is a serious complication of liver cirrhosis (LC) and is closely related to gut homeostasis. The study aimed to investigate the composition of gut microbiota and its putative role in PVT development in LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>33 patients with LC admitted between January 2022 and December 2022 were enrolled in this study. Based on imaging findings, they were categorized into LC without PVT (<jats:italic>n<\/jats:italic>\u2009=\u200921) and LC with PVT (<jats:italic>n<\/jats:italic>\u2009=\u200912) groups. Fecal samples were collected from each participant and underwent 16S rDNA sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>D-Dimer and platelet elevations were the main clinical features of LC with PVT. The alpha and beta diversity of the gut microbiota in LC with PVT group was found to be significantly higher compared to the control group. The structure of the gut microbiota was significantly different between the two groups. Based on LEfSe data, the genera <jats:italic>Akkermansia<\/jats:italic>, <jats:italic>Eubacterium hallii group, Fusicatenibacter<\/jats:italic>, and <jats:italic>Anaerostipes<\/jats:italic> were enriched in the LC with PVT, while <jats:italic>Enterococcus, Weissella, Bacteroides,<\/jats:italic> and <jats:italic>Subdoligranulum<\/jats:italic> were enriched in those of the LC subjects. Changes in microbiota structure result in significant differences in gut microbiota metabolism between the two groups. Altered levels of the microbiota genera were shown to be correlated with coagulation factor parameters. In animal experiments, the addition of <jats:italic>Bacteroides<\/jats:italic> reversed the CCl<jats:sub>4<\/jats:sub>-induced PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver cirrhosis with PVT led to a disorder in the gut microbiota, which was characterized by an increase in pathogenic bacteria and a decrease in beneficial bacteria. Furthermore, modulating the gut microbiota, especially <jats:italic>Bacteroides<\/jats:italic>, may be a promising therapeutic approach to reduce the progression of PVT in LC.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2023.1217338","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T22:48:48Z","timestamp":1698446928000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Potential contribution of the gut microbiota to the development of portal vein thrombosis in liver cirrhosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Xin-yu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-yu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-mao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.3390\/microorganisms10122427","article-title":"The Weissella genus: clinically treatable bacteria with antimicrobial\/probiotic effects on inflammation and cancer","volume":"10","author":"Ahmed","year":"2022","journal-title":"Microorganisms"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1053\/gast.2002.36391","article-title":"Portal and mesenteric venous thrombosis in cirrhotic patients","volume":"123","author":"Amitrano","year":"2002","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/liv.13986","article-title":"Potential mechanisms linking gut microbiota and portal hypertension","volume":"39","author":"Baffy","year":"2019","journal-title":"Liver Int."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3389\/fpsyt.2020.00541","article-title":"Altered composition of gut microbiota in depression: a systematic review","volume":"11","author":"Barandouzi","year":"2020","journal-title":"Front. 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