{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:48:34Z","timestamp":1769503714796,"version":"3.49.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>After COVID-19, there was an outbreak of a new infectious disease caused by monkeypox virus. So far, no specific drug has been found to treat it. Xuanbai Chengqi decoction (XBCQD) has shown effects against a variety of viruses in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched for the active compounds and potential targets for XBCQD from multiple open databases and literature. Monkeypox related targets were searched out from the OMIM and GeneCards databases. After determining the assumed targets of XBCQD for monkeypox treatment, we built the PPI network and used R for GO enrichment and KEGG pathway analysis. The interactions between the active compounds and the hub targets were investigated by molecular docking and molecular dynamics (MD) simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5 active compounds and 10 hub targets of XBCQD were screened out. GO enrichment and KEGG analysis demonstrated that XBCQD plays a therapeutic role in monkeypox mainly by regulating signaling pathways related to viral infection and inflammatory response. The main active compound estrone binding to target AR was confirmed to be the best therapy choice for monkeypox.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study systematically explored the interactions between the bioactive compounds of XBCQD and the monkeypox-specific XBCQD targets using network pharmacological methods, bioinformatics analyses and molecular simulations, suggesting that XBCQD could have a beneficial therapeutic effect on monkeypox by reducing the inflammatory damage and viral replication via multiple pathways. The use of XBCQD on monkeypox disease was confirmed to be best worked through the estrone-target AR interaction. Our work could provide evidence and guidance for further research on the treatment of monkeypox disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2023.1234817","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T08:47:22Z","timestamp":1695286042000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The use of Xuanbai Chengqi decoction on monkeypox disease through the estrone-target AR interaction"],"prefix":"10.3389","volume":"14","author":[{"given":"Yanqi","family":"Jiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengcheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101078","DOI":"10.1016\/j.nmni.2022.101078","article-title":"Factors associated with geographic variations in the 2022 monkeypox outbreak; a systematic review","volume":"51","author":"Abu-Hammad","year":"2023","journal-title":"New Microbes New Infect."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/hep.21196","article-title":"Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma","volume":"43","author":"Branda","year":"2006","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1073\/pnas.0405841102","article-title":"Identification of pathway-selective estrogen receptor ligands that inhibit NF-\u03baB transcriptional activity","volume":"102","author":"Chadwick","year":"2005","journal-title":"Proc. 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