{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:34:27Z","timestamp":1791830067473,"version":"4.3.4"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Grape pomace (GP), a by-product in wine production, is nutritious and can be used as a feed ingredient for ruminants; however, its role in shaping sheep gastrointestinal tract (GIT) microbiota is unclear. We conducted a controlled trial using a randomized block design with 10 Tan lambs fed a control diet (CD) and 10 Tan lambs fed a pelleted diet containing 8% GP (dry matter basis) for 46\u2009days. Rumen, jejunum, cecum, and colon bacterial and archaeal composition were identified by 16S rRNA gene sequencing. Dry matter intake (DMI) was greater (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) in the GP than CD group; however, there was no difference in average daily gain (ADG, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) and feed conversion ratio (FCR, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) between the two groups. The GP group had a greater abundance of <jats:italic>Prevotella 1<\/jats:italic> and <jats:italic>Prevotella 7<\/jats:italic> in the rumen; of <jats:italic>Sharpe<\/jats:italic>, <jats:italic>Ruminococcaceae 2<\/jats:italic>, and <jats:italic>[Ruminococcus] gauvreauii group<\/jats:italic> in the jejunum; of <jats:italic>Ruminococcaceae UCG-014<\/jats:italic> and <jats:italic>Romboutsia<\/jats:italic> in the cecum, and <jats:italic>Prevotella UCG-001<\/jats:italic> in the colon; but lesser <jats:italic>Rikenellaceae RC9 gut group<\/jats:italic> in the rumen and cecum, and <jats:italic>Ruminococcaceae UCG-005<\/jats:italic> and <jats:italic>Ruminococcaceae UCG-010<\/jats:italic> in the colon than the CD group. The pathways of carbohydrate metabolism, such as L-rhamnose degradation in the rumen, starch and glycogen degradation in the jejunum, galactose degradation in the cecum, and mixed acid fermentation and mannan degradation in the colon were up-graded; whereas, the pathways of tricarboxylic acid (TCA) cycle VIII, and pyruvate fermentation to acetone in the rumen and colon were down-graded with GP. The archaeal incomplete reductive TCA cycle was enriched in the rumen, jejunum, and colon; whereas, the methanogenesis from H<jats:sub>2<\/jats:sub> and CO<jats:sub>2<\/jats:sub>, the cofactors of methanogenesis, including coenzyme M, coenzyme B, and factor 420 biosynthesis were decreased in the colon. The study concluded that a diet including GP at 8% DM did not affect ADG or FCR in Tan lambs. However, there were some potential benefits, such as enhancing propionate production by microbiota and pathways in the GIT, promoting B-vitamin production in the rumen, facilitating starch degradation and amino acid biosynthesis in the jejunum, and reducing methanogenesis in the colon.<\/jats:p>","DOI":"10.3389\/fmicb.2023.1264840","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:27:05Z","timestamp":1695965225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of grape pomace supplement on growth performance, gastrointestinal microbiota, and methane production in Tan lambs"],"prefix":"10.3389","volume":"14","author":[{"given":"Xindong","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham Allan","family":"Degen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiukun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.livsci.2010.05.002","article-title":"The influence of the grape pomace on the ruminal parameters of sheep","volume":"132","author":"Abarghuei","year":"2010","journal-title":"Livest. 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