{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:40:20Z","timestamp":1793108420118,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The rapid emergence of drug resistant pathogens is a major threat which has warranted the development of alternative strategies to combat infectious diseases. In this work, we have tested the anti-virulent activity of Meldrum\u2019s acid activated furan (MAF) and 1,3-dimethyl barbituric acid activated furan (BAF) against\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    . It was found that MAF significantly reduced the violacein production and biofilm formation of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    at sub-inhibitory concentrations. The quorum sensing (QS) regulated virulence factors of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    including biofilm formation, motility, pigment production, and elastase activity were also found to be reduced considerably at sub-inhibitory concentrations of MAF. Additionally, MAF downregulated the expression of genes in the QS circuitry of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , demonstrating the potential of MAF in lowering the pathogenicity of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    .\n                    <jats:italic>In silico<\/jats:italic>\n                    studies demonstrated the potential of MAF to compete with the signaling molecules of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    for the QS receptor interaction.\n                    <jats:italic>In vivo<\/jats:italic>\n                    studies using\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    demonstrated the anti-pathogenicity of MAF by enhancing the survival of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    -infected\n                    <jats:italic>C. elegans<\/jats:italic>\n                    . These results suggest that activated furan compounds could be potential inhibitors of QS-mediated virulence factors in\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , encouraging their use in combating multidrug-resistant pathogens.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2023.1272240","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T23:39:46Z","timestamp":1704238786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Mitigation of quorum sensing mediated virulence factors of Pseudomonas aeruginosa: the role of Meldrum\u2019s acid activated furan"],"prefix":"10.3389","volume":"14","author":[{"given":"Ajmal","family":"Sadik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithin P.","family":"Viswaswar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambili","family":"Rajamoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Rekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darsana M.","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Prakashan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mydhili","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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