{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:19:10Z","timestamp":1787026750693,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to investigated the effects of 10-hydroxy-2-decenoic acid (10-HDA) on the growth performance, intestinal barrier, inflammatory response, oxidative stress, and gut microbiota of chickens challenged with lipopolysaccharide (LPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 240 one-day-old chickens were randomly assigned to five treatment groups: (1) control group (basal diet + saline); (2) LPS group (basal diet + LPS); (3) Chlortetracycline (CTC) group (basal diet containing 75\u2009mg\/kg CTC\u2009+\u2009LPS); (4) 0.1% 10-HDA group (basal diet containing 1\u2009g\/kg 10-HDA\u2009+\u2009LPS); and (5) 0.5% 10-HDA group (basal diet containing 5\u2009g\/kg 10-HDA\u2009+\u2009LPS). All chickens were injected intraperitoneally with 0.5\u2009mg\/kg body weight of either LPS or saline at 17, 19, and 21\u2009days of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that dietary 10-HDA supplementation attenuated the loss in growth performance caused by the LPS challenge (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). 10-HDA effectively alleviated LPS-induced intestinal mucosal injury, as evidenced by reduced bleeding, decreased serum diamine oxidase levels (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05), and increased villus\/crypt ratios of the jejunum and ileum (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). Dietary treatment with 0.1% 10-HDA reduced the concentrations of inflammatory cytokines (TNF-\u03b1, IL-1\u03b2, IL-6;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05), and increased immunoglobulin (IgA, IgG) and antioxidant enzyme levels (CAT, GSH-px, T-SOD) in the serum of LPS-challenged chickens (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). These effects were similar to those observed in the CTC group. Moreover, 0.1% 10-HDA treatment reversed the LPS-induced variations in the mRNA expression of genes related to inflammation, antioxidant capacity, and intestinal tight junctions (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). 16S rRNA analysis revealed that 10-HDA supplementation increased the relative abundance of\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and\n                      <jats:italic>Clostridia_UCG-014<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). Additionally, it decreased the abundance of\n                      <jats:italic>Clostridia_vadinBB60_group<\/jats:italic>\n                      ,\n                      <jats:italic>Eubacterium_nodatum_group<\/jats:italic>\n                      , and\n                      <jats:italic>UC5-1-2E3<\/jats:italic>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u20090.05). These changes were correlated with reduced inflammation and improved antioxidant capacity in the LPS-challenged chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, dietary 10-HDA supplementation alleviated LPS-induced intestinal mucosal injury and the loss of growth performance through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens. Moreover, 0.1% 10-HDA supplementation had comparable or even better protection for LPS-challenged chickens than supplementation with antibiotics or 0.5% 10-HDA. 10-HDA has the potential to be used as an alternative to antibiotics in protecting the intestinal health and improving the performance of poultry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2023.1285299","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:17:32Z","timestamp":1697509052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens"],"prefix":"10.3389","volume":"14","author":[{"given":"Lianquan","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3389\/fvets.2018.00348","article-title":"Optimizing gastrointestinal integrity in poultry: the role of nutrients and feed additives","volume":"5","author":"Adedokun","year":"2019","journal-title":"Front. 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