{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:58:12Z","timestamp":1794315492472,"version":"4.9.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    A high-fiber diet is widely recognized for its positive effects on the gut microbiome. However, the specific impact of a high-fiber diet on the gut microbiome and bowel habits of patients with colon cancer remains poorly understood. In this study, we aimed to assess the effects of a modified microbiota-accessible carbohydrate (mMAC) diet on gut microbiota composition and clinical symptoms in colon cancer patients who underwent surgical resection. To achieve this, we enrolled 40 patients in two groups: those who received adjuvant chemotherapy and those who did not. Fecal samples were collected before and after dietary interventions for microbial and metabolite analyses. Each group was randomized in a 1: 1 ratio to follow either a 3-week conventional diet followed by a 3-week mMAC diet, or the reverse sequence. Although there were no significant differences in the microbial diversity data before and after the mMAC diet in both the non-chemotherapy and chemotherapy groups, distinct differences in gut microbial composition were revealed after the mMAC diet. Specifically, the abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    , which is associated with high-fiber diets, was further elevated with increased concentrations of acetate and propionate after the mMAC diet. Additionally, patients who experienced improved diarrhea and constipation after the mMAC diet exhibited an enrichment of beneficial bacteria and notable changes in metabolites. In conclusion, this study provides valuable insights into the potential benefits of the mMAC diet, specifically its impact on the gut microbiome and clinical symptoms in postoperative colorectal cancer (CRC) patients. These findings emphasize the potential role of a high-fiber diet in influencing the gut microbiome, and the clinical symptoms warrant further investigation.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2024.1282932","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:05:00Z","timestamp":1707177900000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of a modified microbiota-accessible carbohydrate diet on gut microbiome and clinical symptoms in colorectal cancer patients following surgical resection"],"prefix":"10.3389","volume":"15","author":[{"given":"Boyeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ho","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Myun","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.maturitas.2014.12.017","article-title":"Diet and colorectal cancer","volume":"80","author":"Baena","year":"2015","journal-title":"Maturitas"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1016\/j.tjnut.2023.09.001","article-title":"Tuning expectations to reality: don't expect increased gut microbiota diversity with dietary fiber","volume":"153","author":"Cantu-Jungles","year":"2023","journal-title":"J. Nutr."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1158\/0008-5472.CAN-09-3929","article-title":"A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association","volume":"70","author":"Cross","year":"2010","journal-title":"Cancer Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1038\/bjc.2011.423","article-title":"The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature","volume":"105","author":"Davies","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3892\/ijmm.2017.3072","article-title":"Dietary fiber in irritable bowel syndrome (review)","volume":"40","author":"El-Salhy","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.3390\/ijms19103097","article-title":"In vitro fermentation of selected prebiotics and their effects on the composition and activity of the adult gut microbiota","volume":"19","author":"Fehlbaum","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40168-016-0160-7","article-title":"Interpreting Prevotella and Bacteroides as biomarkers of diet and lifestyle","volume":"4","author":"Gorvitovskaia","year":"2016","journal-title":"Microbiome"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.3390\/nu14132641","article-title":"Therapeutic benefits and dietary restrictions of fiber intake: a state of the art review","volume":"14","author":"Ioni\u021b\u0103-M\u00eendrican","year":"2022","journal-title":"Nutrients"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.3390\/ijms20174146","article-title":"Oral bacteria and intestinal dysbiosis in colorectal cancer","volume":"20","author":"Koliarakis","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"625210","DOI":"10.3389\/fcimb.2021.625210","article-title":"Gut microbiota and diarrhea: an updated review","volume":"11","author":"Li","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-med-080719-091604","article-title":"Microbiota effects on carcinogenesis: initiation, promotion, and progression","volume":"72","author":"Lopez","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1038\/ctg.2016.53","article-title":"Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location","volume":"7","author":"Mima","year":"","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1136\/gutjnl-2015-310101","article-title":"Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis","volume":"65","author":"Mima","year":"","journal-title":"Gut"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1159\/000516922","article-title":"The comparison of fecal microbiota in left-side and right-side human colorectal cancer","volume":"62","author":"Miyake","year":"2021","journal-title":"Eur. Surg. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"8727","DOI":"10.1038\/ncomms9727","article-title":"Gut mucosal microbiome across stages of colorectal carcinogenesis","volume":"6","author":"Nakatsu","year":"2015","journal-title":"Nat. Commun."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fmed.2019.00019","article-title":"Gut microbiota and chronic constipation: a review and update","volume":"6","author":"Ohkusa","year":"2019","journal-title":"Front Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12967-022-03492-7","article-title":"Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora","volume":"20","author":"Sadrekarimi","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref23","first-page":"591","article-title":"Polyphosphate derived from Lactobacillus brevis inhibits colon cancer progression through induction of cell apoptosis","volume":"36","author":"Sakatani","year":"2016","journal-title":"Anticancer Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mrrev.2009.04.001","article-title":"Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre","volume":"682","author":"Scharlau","year":"2009","journal-title":"Mutat. Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.3892\/ol.2019.10841","article-title":"Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites","volume":"18","author":"Sheng","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/ajcn\/nqy041","article-title":"Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis","volume":"107","author":"So","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1053\/j.gastro.2019.06.048","article-title":"Influence of the gut microbiome, diet, and environment on risk of colorectal Cancer","volume":"158","author":"Song","year":"2020","journal-title":"Gastroenterology"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature16504","article-title":"Diet-induced extinctions in the gut microbiota compound over generations","volume":"529","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1126\/science.aaz7015","article-title":"Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response","volume":"374","author":"Spencer","year":"2021","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12876-022-02382-y","article-title":"The gut microbiota composition in patients with right-and left-sided colorectal cancer and after curative colectomy, as analyzed by 16S rRNA gene amplicon sequencing","volume":"22","author":"Suga","year":"2022","journal-title":"BMC Gastroenterol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e2037341","DOI":"10.1001\/jamanetworkopen.2020.37341","article-title":"Role of diet in colorectal cancer incidence: umbrella review of meta-analyses of prospective observational studies","volume":"4","author":"Veettil","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.3390\/nu14132559","article-title":"Effects of dietary fibers on short-chain fatty acids and gut microbiota composition in healthy adults: a systematic review","volume":"14","author":"Vinelli","year":"2022","journal-title":"Nutrients"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s13668-019-0257-2","article-title":"The role of the microbiome in cancer initiation and progression: how microbes and cancer cells utilize excess energy and promote one another\u2019s growth","volume":"8","author":"Whisner","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s42255-021-00348-0","article-title":"Gut microbiome pattern reflects healthy ageing and predicts survival in humans","volume":"3","author":"Wilmanski","year":"2021","journal-title":"Nat. Metab."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.chom.2020.11.010","article-title":"Fiber sets up the battleground for intestinal Prevotella","volume":"28","author":"Wu","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/s41591-019-0458-7","article-title":"Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer","volume":"25","author":"Yachida","year":"2019","journal-title":"Nat. Med."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"fiab043","DOI":"10.1093\/femsec\/fiab043","article-title":"Gut bacteria formation and influencing factors","volume":"97","author":"Yang","year":"2021","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1007\/s00253-021-11453-1","article-title":"The potential of Akkermansia muciniphila in inflammatory bowel disease","volume":"105","author":"Zhang","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"498502","DOI":"10.3389\/fcimb.2020.498502","article-title":"Microbial community profiling distinguishes left-sided and right-sided colon cancer","volume":"10","author":"Zhong","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1282932\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:05:02Z","timestamp":1707177902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1282932\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":44,"alternative-id":["10.3389\/fmicb.2024.1282932"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1282932","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fmicb.2024.1282932.s001","asserted-by":"subject"}]},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"article-number":"1282932"}}