{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:47:33Z","timestamp":1776682053535,"version":"3.51.2"},"reference-count":130,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202005 and 81871292"],"award-info":[{"award-number":["82202005 and 81871292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Science and Technology Department","doi-asserted-by":"publisher","award":["201901D211511"],"award-info":[{"award-number":["201901D211511"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Mounting evidence suggests microbiota dysbiosis augment autoimmune response. This study aims to provide a systematic overview of this research field in SLE through a bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive search and retrieval of literature related to microbial researches in SLE from the Web of Science Core Collection (WOSCC) database. The retrieved articles were subjected to bibliometric analysis using VOSviewer and Bibliometricx to explore annual publication output, collaborative patterns, research hotspots, current research status, and emerging trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we conducted a comprehensive analysis of 218 research articles and 118 review articles. The quantity of publications rises annually, notably surging in 2015 and 2018. The United States and China emerged as the leading contributors in microbial research of SLE. Mashhad University of Medical Sciences had the highest publication outputs among the institutions. Frontiers in Immunology published the most papers. Luo XM and Margolles A were the most prolific and highly cited contributors among individual authors. Microbial research in SLE primarily focused on changes in microbial composition, particularly gut microbiota, as well as the mechanisms and practical applications in SLE. Recent trends emphasize \u201cmetabolites,\u201d \u201cmetabolomics,\u201d \u201cfatty acids,\u201d \u201cT cells,\u201d \u201c<jats:italic>lactobacillus<\/jats:italic>,\u201d and \u201cdietary supplementation,\u201d indicating a growing emphasis on microbial metabolism and interventions in SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides a thorough analysis of the research landscape concerning microbiota in SLE. The microbial research in SLE mainly focused on three aspects: microbial dysbiosis, mechanism studies and translational studies (microbiota-based therapeutics). It identifies current research trends and focal points, offering valuable guidance for scholars in the field.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1319654","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:23:06Z","timestamp":1716906186000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Microbial dysbiosis in systemic lupus erythematosus: a scientometric study"],"prefix":"10.3389","volume":"15","author":[{"given":"Miaomiao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3389\/fimmu.2020.00408","article-title":"Retinoic acid exerts disease stage-dependent effects on Pristane-induced lupus","volume":"11","author":"Abdelhamid","year":"2020","journal-title":"Front. Immunol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/nu10081016","article-title":"Retinoic acid, leaky gut, and autoimmune diseases","volume":"10","author":"Abdelhamid","year":"2018","journal-title":"Nutrients"},{"key":"ref3","first-page":"S27","article-title":"Role of infectious agents in systemic rheumatic diseases","volume":"26","author":"Amital","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1017\/S0950268800057770","article-title":"Host-microflora interaction in systemic lupus erythematosus (SLE): colonization resistance of the indigenous bacteria of the intestinal tract","volume":"112","author":"Apperloo-Renkema","year":"1994","journal-title":"Epidemiol. Infect."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1017\/S0950268800051980","article-title":"Host-microflora interaction in systemic lupus erythematosus (SLE): circulating antibodies to the indigenous bacteria of the intestinal tract","volume":"114","author":"Apperloo-Renkema","year":"1995","journal-title":"Epidemiol. Infect."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informet."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/dna.2009.0874","article-title":"The oral microbiota: living with a permanent guest","volume":"28","author":"Avila","year":"2009","journal-title":"DNA Cell Biol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1136\/annrheumdis-2018-214856","article-title":"Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal","volume":"78","author":"Azzouz","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"ref10","first-page":"715","article-title":"Superantigens and autoimmunity","volume":"126","author":"Baharav","year":"1994","journal-title":"Harefuah"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/BOR.0000000000000318","article-title":"Environmental exposures and the development of systemic lupus erythematosus","volume":"28","author":"Barbhaiya","year":"2016","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1191\/0961203305lu2157oa","article-title":"High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk","volume":"14","author":"Barnes","year":"2005","journal-title":"Lupus"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"101798","DOI":"10.1016\/j.isci.2020.101798","article-title":"Bacterially derived tryptamine increases mucus release by activating a host receptor in a mouse model of inflammatory bowel disease","volume":"23","author":"Bhattarai","year":"2020","journal-title":"iScience"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.chom.2018.05.004","article-title":"Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion","volume":"23","author":"Bhattarai","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s12026-013-8399-6","article-title":"Tracing environmental markers of autoimmunity: introducing the infectome","volume":"56","author":"Bogdanos","year":"2013","journal-title":"Immunol. Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000236813","article-title":"Characterization of antibodies to bacterial double-stranded DNA in the sera of normal human subjects","volume":"105","author":"Bunyard","year":"1994","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4049\/immunohorizons.2100082","article-title":"Phenotypic drift in lupus-prone MRL\/lpr mice: potential roles of MicroRNAs and gut microbiota","volume":"6","author":"Cabana-Puig","year":"2022","journal-title":"Immunohorizons"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/cei.13184","article-title":"Porphyromonas gingivalis in the tongue biofilm is associated with clinical outcome in rheumatoid arthritis patients","volume":"194","author":"Ceccarelli","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/art.41511","article-title":"An autoimmunogenic and Proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus","volume":"73","author":"Chen","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12654","article-title":"Microbiome, autoimmunity, allergy, and helminth infection: the importance of the pregnancy period","volume":"78","author":"Chen","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"eaax2220","DOI":"10.1126\/scitranslmed.aax2220","article-title":"Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice","volume":"12","author":"Choi","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"946248","DOI":"10.3389\/fimmu.2022.946248","article-title":"Gut microbiota, leaky gut, and autoimmune diseases","volume":"13","author":"Christovich","year":"2022","journal-title":"Front. Immunol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40168-017-0252-z","article-title":"Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status","volume":"5","author":"Corr\u00eaa","year":"2017","journal-title":"Microbiome"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3390\/nu7021301","article-title":"Association of polyphenols from oranges and apples with specific intestinal microorganisms in systemic lupus erythematosus patients","volume":"7","author":"Cuervo","year":"2015","journal-title":"Nutrients"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1177\/0734242X21992422","article-title":"Management of plastic waste: a bibliometric mapping and analysis","volume":"39","author":"de Sousa","year":"2021","journal-title":"Waste Manag. Res."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3390\/antiox10091426","article-title":"Gut microbiota has a crucial role in the development of hypertension and vascular dysfunction in toll-like receptor 7-driven lupus autoimmunity","volume":"10","author":"de la Visitaci\u00f3n","year":"","journal-title":"Antioxidants (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.3390\/nu13082669","article-title":"Probiotics prevent hypertension in a murine model of systemic lupus erythematosus induced by toll-like receptor 7 activation","volume":"13","author":"de la Visitaci\u00f3n","year":"","journal-title":"Nutrients"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.3390\/nu11112676","article-title":"Protective effects of probiotic consumption in cardiovascular disease in systemic lupus erythematosus","volume":"11","author":"de la Visitaci\u00f3n","year":"2019","journal-title":"Nutrients"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1111\/bph.15512","article-title":"Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus","volume":"178","author":"de la Visitaci\u00f3n","year":"","journal-title":"Br. J. Pharmacol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1039\/D0FO00578A","article-title":"Lactobacillus fermentum CECT5716 prevents renal damage in the NZBWF1 mouse model of systemic lupus erythematosus","volume":"11","author":"de la Visitaci\u00f3n","year":"2020","journal-title":"Food Funct."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/cei.13158","article-title":"The microbiome in autoimmune diseases","volume":"195","author":"De Luca","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1084\/jem.189.3.531","article-title":"Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies","volume":"189","author":"Deshmukh","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1074\/jbc.M111.238477","article-title":"Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid","volume":"287","author":"di Domizio","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"Dominguez-Bello","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.autrev.2008.07.014","article-title":"Infections, rheumatism and autoimmunity: the conflicting relationship between humans and their environment","volume":"8","author":"Doria","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/intimm\/dxx033","article-title":"Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL\/lpr mice","volume":"29","author":"Edwards","year":"2017","journal-title":"Int. Immunol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1136\/annrheumdis-2020-218272","article-title":"Update \u03bfn the diagnosis and management of systemic lupus erythematosus","volume":"80","author":"Fanouriakis","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.immuni.2015.06.002","article-title":"Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity","volume":"42","author":"Gallo","year":"2015","journal-title":"Immunity"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e01762","DOI":"10.1128\/mBio.01762-19","article-title":"Streamlined genetic manipulation of diverse Bacteroides and Parabacteroides isolates from the human gut microbiota","volume":"10","author":"Garc\u00eda-Bayona","year":"2019","journal-title":"MBio"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1172\/JCI117793","article-title":"Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB\/NZW mice by immunization with bacterial DNA","volume":"95","author":"Gilkeson","year":"1995","journal-title":"J. Clin. Invest."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/0090-1229(91)90025-6","article-title":"Specificity of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA","volume":"59","author":"Gilkeson","year":"1991","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0140-6736(13)61499-3","article-title":"Clinical aspects of autoimmune rheumatic diseases","volume":"382","author":"Goldblatt","year":"2013","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/ibd\/izx029","article-title":"A Cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel disease","volume":"24","author":"Gon\u00e7alves","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"934","DOI":"10.20960\/nh.546","article-title":"Microbiota and oxidant-antioxidant balance in systemic lupus erythematosus","volume":"34","author":"Gonz\u00e1lez","year":"2017","journal-title":"Nutr. Hosp."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/antiox11010084","article-title":"Trimethylamine N-oxide promotes autoimmunity and a loss of vascular function in toll-like receptor 7-driven lupus mice","volume":"11","author":"Gonz\u00e1lez-Correa","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/rheumatology\/kex286","article-title":"The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults","volume":"57","author":"Gordon","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"eaan2306","DOI":"10.1126\/scitranslmed.aan2306","article-title":"Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus","volume":"10","author":"Greiling","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12967-023-03892-3","article-title":"Alterations in the human oral microbiota in systemic lupus erythematosus","volume":"21","author":"Guo","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"10438","DOI":"10.1021\/acs.jafc.8b04102","article-title":"Could fecal Phenylacetic and Phenylpropionic acids be used as indicators of health status?","volume":"66","author":"Guti\u00e9rrez-D\u00edaz","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.clim.2005.10.009","article-title":"The binding of sera of patients with SLE to bacterial and mammalian DNA","volume":"118","author":"Hamilton","year":"2006","journal-title":"Clin. Immunol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.3389\/fmicb.2015.01285","article-title":"Molecular players involved in the interaction between beneficial Bacteria and the immune system","volume":"6","author":"Hevia","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/351204","article-title":"Association of Levels of antibodies from patients with inflammatory bowel disease with extracellular proteins of food and probiotic Bacteria","volume":"2014","author":"Hevia","year":"","journal-title":"Biomed. Res. Int."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e01548","DOI":"10.1128\/mBio.01548-14","article-title":"Intestinal dysbiosis associated with systemic lupus erythematosus","volume":"5","author":"Hevia","year":"","journal-title":"MBio"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"102391","DOI":"10.1016\/j.jaut.2019.102391","article-title":"Disordered cutaneous microbiota in systemic lupus erythematosus","volume":"108","author":"Huang","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"102844","DOI":"10.1016\/j.jaut.2022.102844","article-title":"Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: an EXPLORER trial","volume":"130","author":"Huang","year":"2022","journal-title":"J. Autoimmun."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.3389\/fimmu.2017.01429","article-title":"Butyrate conditions human dendritic cells to prime type 1 regulatory T cells via both histone deacetylase inhibition and G protein-coupled receptor 109A signaling","volume":"8","author":"Kaisar","year":"2017","journal-title":"Front. Immunol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"102765","DOI":"10.1016\/j.autrev.2021.102765","article-title":"The microbiome links between aging and lupus","volume":"20","author":"Katz-Agranov","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"ITC81","DOI":"10.7326\/AITC202006020","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e1002995","DOI":"10.1371\/journal.ppat.1002995","article-title":"Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice","volume":"8","author":"Lawley","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.chom.2018.11.002","article-title":"Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development","volume":"24","author":"Lee","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1126\/science.1195568","article-title":"Has the microbiota played a critical role in the evolution of the adaptive immune system?","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1001\/jama.2015.18098","article-title":"Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial","volume":"315","author":"Lee","year":"2016","journal-title":"JAMA"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.3168\/jds.2019-18003","article-title":"Probiotics, prebiotics, and synbiotics regulate the intestinal microbiota differentially and restore the relative abundance of specific gut microorganisms","volume":"103","author":"Li","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.cell.2017.03.045","article-title":"Engineered regulatory systems modulate gene expression of human commensals in the gut","volume":"169","author":"Lim","year":"2017","journal-title":"Cell"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"24072","DOI":"10.1038\/srep24072","article-title":"Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients","volume":"6","author":"L\u00f3pez","year":"","journal-title":"Sci. Rep."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/BOR.0000000000000309","article-title":"Intestinal dysbiosis in systemic lupus erythematosus: cause or consequence?","volume":"28","author":"L\u00f3pez","year":"","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.3390\/v4123701","article-title":"Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis\u2014association and causation","volume":"4","author":"Lossius","year":"2012","journal-title":"Viruses"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"613268","DOI":"10.3389\/fmicb.2020.613268","article-title":"Rigorous plasma microbiome analysis method enables disease association discovery in clinic","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"e02288","DOI":"10.1128\/AEM.02288-17","article-title":"Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus","volume":"84","author":"Luo","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s10020-019-0102-5","article-title":"Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus","volume":"25","author":"Ma","year":"2019","journal-title":"Mol. Med."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aar7201","article-title":"Translocation of a gut pathobiont drives autoimmunity in mice and humans","volume":"359","author":"Manfredo Vieira","year":"2018","journal-title":"Science"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/apm.13225","article-title":"The human microbiome in disease and pathology","volume":"130","author":"Manos","year":"2022","journal-title":"APMIS"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/CMR.00050-12","article-title":"Microbial translocation in the pathogenesis of HIV infection and AIDS","volume":"26","author":"Marchetti","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cyto.2016.06.025","article-title":"Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study","volume":"85","author":"Marques","year":"2016","journal-title":"Cytokine"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/08916934.2018.1494161","article-title":"Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: a crucial role for aryl hydrocarbon receptor","volume":"51","author":"Mohammadi","year":"2018","journal-title":"Autoimmunity"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s40168-019-0720-8","article-title":"Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota","volume":"7","author":"Mu","year":"2019","journal-title":"Microbiome"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"593353","DOI":"10.3389\/fimmu.2020.593353","article-title":"Gut microbiota and bacterial DNA suppress autoimmunity by stimulating regulatory B cells in a murine model of lupus","volume":"11","author":"Mu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3389\/fimmu.2017.00598","article-title":"Leaky gut as a danger signal for autoimmune diseases","volume":"8","author":"Mu","year":"","journal-title":"Front. Immunol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"13675","DOI":"10.1038\/s41598-017-14223-0","article-title":"Antibiotics ameliorate lupus-like symptoms in mice","volume":"7","author":"Mu","year":"","journal-title":"Sci. Rep."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s40168-017-0300-8","article-title":"Control of lupus nephritis by changes of gut microbiota","volume":"5","author":"Mu","year":"","journal-title":"Microbiome"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3389\/fimmu.2015.00608","article-title":"SLE: another autoimmune disorder influenced by microbes and diet?","volume":"6","author":"Mu","year":"2015","journal-title":"Front. Immunol."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0000000000000628","article-title":"Microbiome and autoimmune diseases: cause and effect relationship","volume":"31","author":"Nogueira","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1002\/art.40935","article-title":"A link between plasma microbial translocation, microbiome, and autoantibody development in first-degree relatives of systemic lupus erythematosus patients","volume":"71","author":"Ogunrinde","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s10661-023-11094-z","article-title":"Bibliometric analysis of chitosan research for wastewater treatment: a review","volume":"195","author":"Ola","year":"2023","journal-title":"Environ. Monit. Assess."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3389\/fimmu.2019.00426","article-title":"Microbiome dependent regulation of Tregs and Th17 cells in mucosa","volume":"10","author":"Pandiyan","year":"2019","journal-title":"Front. Immunol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1097\/JS9.0000000000000720","article-title":"Global trends and prospects in health economics of robotic surgery: a bibliometric analysis","volume":"109","author":"Peng","year":"2023","journal-title":"Int. J. Surg."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S1382-6689(97)10026-6","article-title":"The influence of susceptibility factors on the immune response to DNA","volume":"4","author":"Pisetsky","year":"1997","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12016-007-8048-8","article-title":"Infections and autoimmunity: a panorama","volume":"34","author":"Pordeus","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6908677","article-title":"The role of diet in influencing the diversity of gut microbiome related to lupus disease activities: a systematic review","volume":"2022","author":"Putri","year":"2022","journal-title":"Int. J. Microbiol."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.phrs.2018.11.023","article-title":"The role of microbiota in the pathogenesis of lupus: dose it impact lupus nephritis?","volume":"139","author":"Rahbar Saadat","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1191\/0961203303lu1015oa","article-title":"Predictive value of autoantibodies for activity of systemic lupus erythematosus","volume":"13","author":"Reveille","year":"2004","journal-title":"Lupus"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1177\/0961203311418706","article-title":"Is there any correlation between high sensitive CRP and disease activity in systemic lupus erythematosus?","volume":"20","author":"Rezaieyazdi","year":"2011","journal-title":"Lupus"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0090-1229(92)90019-K","article-title":"Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus","volume":"62","author":"Robertson","year":"1992","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref99","first-page":"589","article-title":"Specificity analysis of antibodies to single-stranded micrococcal DNA in the sera of normal human subjects and patients with systemic lupus erythematosus","volume":"10","author":"Robertson","year":"1992","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fimmu.2017.00023","article-title":"Intestinal Dysbiosis is associated with altered short-chain fatty acids and serum-free fatty acids in systemic lupus erythematosus","volume":"8","author":"Rodr\u00edguez-Carrio","year":"","journal-title":"Front. Immunol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3389\/fimmu.2017.00823","article-title":"Free fatty acids profiles are related to gut microbiota signatures and short-chain fatty acids","volume":"8","author":"Rodr\u00edguez-Carrio","year":"","journal-title":"Front. Immunol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"8310","DOI":"10.1038\/srep08310","article-title":"Ranking the impact of human health disorders on gut metabolism: systemic lupus erythematosus and obesity as study cases","volume":"5","author":"Rojo","year":"2015","journal-title":"Sci. Rep."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3389\/fimmu.2015.00610","article-title":"Disturbed T cell signaling and altered Th17 and regulatory T cell subsets in the pathogenesis of systemic lupus erythematosus","volume":"6","author":"Rother","year":"2015","journal-title":"Front. Immunol."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1080\/1744666X.2018.1519395","article-title":"The role of gut microbiota in lupus: what we know in 2018?","volume":"14","author":"Ruiz","year":"2018","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fimmu.2017.01295","article-title":"Association between systemic lupus erythematosus and periodontitis: a systematic review and Meta-analysis","volume":"8","author":"Rutter-Locher","year":"2017","journal-title":"Front. Immunol."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41423-018-0013-3","article-title":"T cells from induced and spontaneous models of SLE recognize a common T cell epitope on \u03b22-glycoprotein I","volume":"16","author":"Salem","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3389\/fimmu.2015.00594","article-title":"Interaction of intestinal microorganisms with the human host in the framework of autoimmune diseases","volume":"6","author":"S\u00e1nchez","year":"2015","journal-title":"Front. Immunol."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1007\/s00018-019-03196-0","article-title":"Polyamines in mammalian pathophysiology","volume":"76","author":"S\u00e1nchez-Jim\u00e9nez","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1191\/0961203302lu247oa","article-title":"The autoimmune response to chromatin antigens in systemic lupus erythematosus: autoantibodies against histone H1 are a highly specific marker for SLE associated with increased disease activity","volume":"11","author":"Schett","year":"2002","journal-title":"Lupus"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2018.12.003","article-title":"The kaleidoscope of autoimmunity - from genes to microbiome","volume":"199","author":"Shoenfeld","year":"2019","journal-title":"Clin. Immunol."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1136\/annrheumdis-2021-220687","article-title":"Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese","volume":"80","author":"Tomofuji","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"102530","DOI":"10.1016\/j.autrev.2020.102530","article-title":"Microbiota and metabolites in rheumatic diseases","volume":"19","author":"Tong","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref113","doi-asserted-by":"publisher","first-page":"10005","DOI":"10.1096\/fj.201900545RR","article-title":"Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus","volume":"33","author":"Toral","year":"2019","journal-title":"FASEB J."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/0140-6736(90)90574-O","article-title":"Bacteriotherapy for Clostridium difficile diarrhoea","volume":"335","author":"Tvede","year":"1990","journal-title":"Lancet"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.semarthrit.2017.06.007","article-title":"Concordance of autoimmune disease in a nationwide Danish systemic lupus erythematosus twin cohort","volume":"47","author":"Ulff-M\u00f8ller","year":"2018","journal-title":"Semin. Arthritis Rheum."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van","year":"2010","journal-title":"Scientometrics"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1177\/0961203313501401","article-title":"Diet, microbiota and autoimmune diseases","volume":"23","author":"Vieira","year":"2014","journal-title":"Lupus"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1007\/s00018-019-03190-6","article-title":"Bridging intestinal immunity and gut microbiota by metabolites","volume":"76","author":"Wang","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"e46014","DOI":"10.2196\/46014","article-title":"Application of artificial intelligence in geriatric care: bibliometric analysis","volume":"25","author":"Wang","year":"2023","journal-title":"J. Med. Internet Res."},{"key":"ref120","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s13075-021-02620-w","article-title":"Gut microbiota mediated the therapeutic efficacies and the side effects of prednisone in the treatment of MRL\/lpr mice","volume":"23","author":"Wang","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.3390\/cells11213419","article-title":"Changes in gut microbiota and systemic inflammation after Synbiotic supplementation in patients with systemic lupus erythematosus: a randomized, double-blind, placebo-controlled trial","volume":"11","author":"Widhani","year":"2022","journal-title":"Cells"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2249.1997.4301328.x","article-title":"Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE)","volume":"109","author":"Wu","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"ref123","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/mi.2015.74","article-title":"Foxp3(+) T cells expressing ROR\u03b3t represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation","volume":"9","author":"Yang","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref124","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1046\/j.1365-2133.1996.d01-1004.x","article-title":"Cutaneous manifestations of systemic lupus erythematosus","volume":"135","author":"Yell","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"ref125","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.chom.2018.11.009","article-title":"A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity","volume":"25","author":"Zegarra-Ruiz","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"7551","DOI":"10.1128\/AEM.02676-14","article-title":"Dynamics of gut microbiota in autoimmune lupus","volume":"80","author":"Zhang","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"686501","DOI":"10.3389\/fimmu.2021.686501","article-title":"Gut microbiome and metabolites in systemic lupus erythematosus: link, mechanisms and intervention","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2008\/683489","article-title":"A possible link between infection with burkholderia bacteria and systemic lupus erythematosus based on epitope mimicry","volume":"2008","author":"Zhang","year":"2008","journal-title":"Clin. Dev. Immunol."},{"key":"ref129","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1177\/09612033211025095","article-title":"Systemic lupus erythematosus patients have a distinct structural and functional skin microbiota compared with controls","volume":"30","author":"Zhou","year":"2021","journal-title":"Lupus"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"4","DOI":"10.55563\/clinexprheumatol\/nolysy","article-title":"One year in review 2022: systemic lupus erythematosus","volume":"40","author":"Zucchi","year":"2022","journal-title":"Clin. Exp. Rheumatol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1319654\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:23:13Z","timestamp":1716906193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1319654\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":130,"alternative-id":["10.3389\/fmicb.2024.1319654"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1319654","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"article-number":"1319654"}}