{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:31:02Z","timestamp":1787686262352,"version":"build-2784847793"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"publisher","award":["333858"],"award-info":[{"award-number":["333858"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013281","name":"Joint Programming Initiative on Antimicrobial Resistance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Antimicrobial resistance is a major threat to human health and must be approached from a One Health perspective. Use of antimicrobials in animal husbandry can lead to dissemination and persistence of resistance in human pathogens. Polyether ionophores (PIs) have antimicrobial activities and are among the most extensively used feed additives for major production animals. Recent discoveries of genetically encoded PI resistance mechanisms and co-localization of resistance mechanisms against PIs and antimicrobials used in human medicine on transferrable plasmids, have raised concerns that use of PIs as feed additives bear potential risks for human health. This review summarizes the current knowledge on PI resistance and discusses the potential consequences of PI-usage as feed additives in a One Health perspective.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1347490","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:26:13Z","timestamp":1706502373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Polyether ionophore resistance in a one health perspective"],"prefix":"10.3389","volume":"15","author":[{"given":"Rikki Franklin","family":"Frederiksen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannice Schau","family":"Sletteme\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silje","family":"Granstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Lagesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel G.","family":"Pikkemaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Margrete","family":"Urdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Simm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0005-2736(88)90151-4","article-title":"The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid a","volume":"938","author":"Antonenko","year":"1988","journal-title":"BBA Biomembr."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e03284","DOI":"10.1128\/mBio.03284-19","article-title":"Plasmids shaped the recent emergence of the major nosocomial pathogen Enterococcus faecium","volume":"11","author":"Arredondo-Alonso","year":"2020","journal-title":"MBio"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-46403-4_5","article-title":"Ionophore antibiotics","volume-title":"Mechanism of Action of Antibacterial Agents","author":"Bakker","year":"1979"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41579-019-0196-3","article-title":"Definitions and guidelines for research on antibiotic persistence","volume":"17","author":"Balaban","year":"2019","journal-title":"Nat. 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Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/jac\/dkl530","article-title":"Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection","volume":"59","author":"Dahl","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref18","year":"2023"},{"key":"ref19","year":"2006"},{"key":"ref20","year":"2016"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1128\/aem.53.10.2363-2367.1987","article-title":"Effects of potassium ion concentrations on the antimicrobial activities of ionophores against ruminal anaerobes","volume":"53","author":"Dawson","year":"1987","journal-title":"Appl. Environ. 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Chem."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1365-2958.1994.tb00355.x","article-title":"An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin","volume":"11","author":"Linton","year":"1994","journal-title":"Mol. Microbiol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"343","DOI":"10.7164\/antibiotics.36.343","article-title":"Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing culture","volume":"36","author":"Liu","year":"1983","journal-title":"J. Antibiot."},{"key":"ref44","year":"2014"},{"key":"ref45","year":"2023"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.3390\/foods11182738","article-title":"Coccidiostats and poultry: a comprehensive review and current legislation","volume":"11","author":"Martins","year":"2022","journal-title":"Foods"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e0001305","DOI":"10.1371\/journal.pgph.0001305","article-title":"Global trends in antimicrobial use in food-producing animals: 2020 to 2030","volume":"3","author":"Mulchandani","year":"2023","journal-title":"PLOS Glob. 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Bacteriol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1365-2672.1992.tb04883.x","article-title":"Properties of ionophore-resistant Bacteroides rurninicola enriched by cultivation in the presence of tetronasin","volume":"72","author":"Newbold","year":"1992","journal-title":"J. Appl. Bacteriol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jgar.2018.12.013","article-title":"The rise and fall of a vancomycin-resistant clone of Enterococcus faecium among broilers in Sweden","volume":"17","author":"Nilsson","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/j.1365-2672.2012.05254.x","article-title":"Genetic diversity among VRE isolates from Swedish broilers with the coincidental finding of transferrable decreased susceptibility to narasin","volume":"112","author":"Nilsson","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.vetmic.2016.01.012","article-title":"Transferable genes putatively conferring elevated minimum inhibitory concentrations of narasin in Enterococcus faecium from Swedish broilers","volume":"184","author":"Nilsson","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0378-1097(92)90528-V","article-title":"Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus","volume":"93","author":"Noble","year":"1992","journal-title":"FEMS Microbiol. Lett."},{"key":"ref58","year":"2023"},{"key":"ref59","year":"2005"},{"key":"ref60","year":"2008"},{"key":"ref61","article-title":"Usage of antimicrobial agents and occurrence of antimicrobial resistance in Norway","year":"2009"},{"key":"ref62","year":"2010"},{"key":"ref63","year":"2014"},{"key":"ref64","year":"2019"},{"key":"ref65","year":"2021"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fmicb.2013.00103","article-title":"The intrinsic resistome of bacterial pathogens","volume":"4","author":"Olivares","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref67","year":"2016"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18174\/565488","article-title":"Ionophore resistance and potential risk of ionophore driven co-selection of clinically relevant antimicrobial resistance in poultry","author":"Pikkemaat","year":"2022","journal-title":"Wageningen Food Safety Res."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s42003-022-03239-6","article-title":"Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome","volume":"5","author":"Plata","year":"2022","journal-title":"Commun. Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-021-21749-5","article-title":"Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era","volume":"12","author":"P\u00f6ntinen","year":"2021","journal-title":"Nat. Commun."},{"key":"ref71","first-page":"1283","article-title":"Ionophorous antibiotics as models for biological transport","volume":"27","author":"Pressman","year":"1968","journal-title":"Fed. Proc."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"184182","DOI":"10.1016\/j.bbamem.2023.184182","article-title":"Selectivity of cation transport across lipid membranes by the antibiotic salinomycin","volume":"1865","author":"Rokitskaya","year":"2023","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.2527\/jas1987.6451519x","article-title":"A proposed mechanism of monensin action in inhibiting ruminal bacterial growth: effects on ion flux and protonmotive force","volume":"64","author":"Russell","year":"1987","journal-title":"J. Anim. Sci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/aem.55.1.1-6.1989","article-title":"Effect of Ionophores on ruminal fermentation","volume":"55","author":"Russell","year":"1989","journal-title":"Appl. Environ. Microbiol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1128\/aem.54.4.872-877.1988","article-title":"Enrichment and isolation of a ruminal bacterium with a very high specific activity of ammonia production","volume":"54","author":"Russell","year":"1988","journal-title":"Appl. Environ. Microbiol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.3168\/jds.S0022-0302(90)78987-4","article-title":"Strategies of nutrient transport by ruminal bacteria","volume":"73","author":"Russell","year":"1990","journal-title":"J. Dairy Sci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"162513","DOI":"10.1155\/2013\/162513","article-title":"Structures and properties of naturally occurring polyether antibiotics","volume":"2013","author":"Rutkowski","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1574-6968.2002.tb11115.x","article-title":"The adaptation and resistance of Clostridium aminophilum F to the butyrivibriocin-like substance of Butyrivibrio fibrisolvens JL5 and monensin","volume":"209","author":"Rychlik","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.3168\/jds.2016-11994","article-title":"Differential effects of monensin and a blend of essential oils on rumen microbiota composition of transition dairy cows","volume":"100","author":"Scharen","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1093\/jac\/dks236","article-title":"Reversible monensin adaptation in Enterococcus faecium, Enterococcus faecalis and Clostridium perfringens of cattle origin: potential impact on human food safety","volume":"67","author":"Simjee","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"e0226101","DOI":"10.1371\/journal.pone.0226101","article-title":"Significant reduction of vancomycin resistant E. faecium in the Norwegian broiler population coincided with measures taken by the broiler industry to reduce antimicrobial resistant bacteria","volume":"14","author":"Simm","year":"2019","journal-title":"PLoS One"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.plasmid.2008.04.002","article-title":"Complete sequence of Enterococcus faecium pVEF3 and the detection of an \u03c9-\u03b5-\u03b6 toxin-antitoxin module and an ABC transporter","volume":"60","author":"Sletvold","year":"2008","journal-title":"Plasmid"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1128\/AAC.00557-06","article-title":"Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway","volume":"51","author":"Sletvold","year":"2007","journal-title":"Antimicrob. 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