{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:21:05Z","timestamp":1788790865607,"version":"build-2803163510"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41877400"],"award-info":[{"award-number":["41877400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011370","name":"State Key Laboratory of Environmental Geochemistry","doi-asserted-by":"publisher","award":["2018YFC1802601"],"award-info":[{"award-number":["2018YFC1802601"]}],"id":[{"id":"10.13039\/501100011370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011370","name":"State Key Laboratory of Environmental Geochemistry","doi-asserted-by":"publisher","award":["SKLEG2018911"],"award-info":[{"award-number":["SKLEG2018911"]}],"id":[{"id":"10.13039\/501100011370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The plant microbiota is believed to be an accessory genome that extends plant functions, forming holobionts together with the host plant. Plant disease resistance, therefore, is inextricably linked with plant microbiota, which play important roles in plant growth and health. To explore the relationship between plant microbiota and disease resistance, we investigated the tobacco microbiome of two varieties with contrasting disease-resistance levels to bacterial wilt and black shank diseases. Comparative microbiome analysis indicated that the resistant variety assembled a distinct microbiota with higher network complexity and diversity. While <jats:italic>Pseudomonas<\/jats:italic> and <jats:italic>Ensifer,<\/jats:italic> which contain biocontrol and beneficial members, were enriched in the rhizosphere of the resistant variety, <jats:italic>Ralstonia<\/jats:italic>, a genus including the known causative pathogen, was enriched in the susceptible variety. Metagenome sequencing revealed that biocontrol functions, such as hydrogen cyanide synthase, pyochelin biosynthesis, and arthrofactin-type cyclic lipopeptide synthetase, were more abundant in the resistant variety. Further analysis indicated that contigs encoding the corresponding genes were mostly assigned to <jats:italic>Pseudomonas<\/jats:italic>. Among all the metagenome-assembled genomes, positive selection was suggested in the genome assigned to <jats:italic>Pseudomonas<\/jats:italic> only in the rhizosphere of the resistant variety. The search of biosynthetic gene clusters in the <jats:italic>Pseudomonas<\/jats:italic> genome revealed a non-ribosomal peptide synthetase, the compound of which was brabantamide A, with known antimicrobial activity. Collectively, our study suggests that the plant microbiota might be involved in microbe-mediated disease resistance. Particularly, our results highlight <jats:italic>Pseudomonas<\/jats:italic> in the rhizosphere of the disease-resistant variety as a promising biocontrol candidate. Our study may facilitate further screening of bacterial isolates and the targeted design of microbial communities.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1361883","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T04:57:41Z","timestamp":1709269061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Distinct microbiota assembly and functional patterns in disease-resistant and susceptible varieties of tobacco"],"prefix":"10.3389","volume":"15","author":[{"given":"Luhua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likai","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6394","DOI":"10.1073\/pnas.0611019104","article-title":"Structure and evolution of the ivy protein family, unexpected lysozyme inhibitors in gram-negative bacteria","volume":"104","author":"Abergel","year":"2007","journal-title":"Proc. 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