{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:25:40Z","timestamp":1793485540460,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>In high-altitude environments characterized by low pressure and oxygen levels, the intestinal microbiota undergoes significant alterations. Whether individuals are subjected to prolonged exposure or acute altitude changes, these conditions lead to shifts in both the diversity and abundance of intestinal microbiota and changes in their composition. While these alterations represent adaptations to high-altitude conditions, they may also pose health risks through certain mechanisms. Changes in the intestinal microbiota induced by high altitudes can compromise the integrity of the intestinal mucosal barrier, resulting in gastrointestinal dysfunction and an increased susceptibility to acute mountain sickness (AMS). Moreover, alterations in the intestinal microbiota have been implicated in the induction or exacerbation of chronic heart failure. Targeted modulation of the intestinal microbiota holds promise in mitigating high-altitude-related cardiac damage. Dietary interventions, such as adopting a high-carbohydrate, high-fiber, low-protein, and low-fat diet, can help regulate the effects of intestinal microbiota and their metabolic byproducts on intestinal health. Additionally, supplementation with probiotics, either through dietary sources or medications, offers a means of modulating the composition of the intestinal microbiota. These interventions may offer beneficial effects in preventing and alleviating AMS following acute exposure to high altitudes.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1369627","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T01:13:24Z","timestamp":1715217204000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["High-altitude-induced alterations in intestinal microbiota"],"prefix":"10.3389","volume":"15","author":[{"given":"Dan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref1","first-page":"1098","article-title":"Modulation of small intestinal homeostasis along with its microflora during acclimatization at simulated hypobaric hypoxia","volume":"52","author":"Adak","year":"","journal-title":"Indian J. Exp. Biol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1055\/s-0033-1336007","article-title":"Alteration of predominant gastrointestinal flora and oxidative damage of large intestine under simulated hypobaric hypoxia","volume":"52","author":"Adak","year":"","journal-title":"Z. Gastroenterol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s12223-013-0241-y","article-title":"Dynamics of predominant microbiota in the human gastrointestinal tract and change in luminal enzymes and immunoglobulin profile during high-altitude adaptation","volume":"58","author":"Adak","year":"2013","journal-title":"Folia Microbiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e162622","DOI":"10.1128\/spectrum.01626-22","article-title":"Changes in the gut microbiota of rats in high-altitude hypoxic environments","volume":"10","author":"Bai","year":"2022","journal-title":"Microbiol. 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Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.cmet.2015.07.026","article-title":"Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling","volume":"22","author":"Caesar","year":"2015","journal-title":"Cell Metab."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","volume":"17","author":"Canani","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1469-0691.2012.03866.x","article-title":"Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue","volume":"18","author":"Cani","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41576-019-0124-4","article-title":"Gut microbial structural variation links to human health","volume":"20","author":"Clyde","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41564-017-0072-8","article-title":"Enterotypes in the landscape of gut microbial community composition","volume":"3","author":"Costea","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front. Immunol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"10104","DOI":"10.1038\/s41598-018-28550-3","article-title":"Analysis of the gut microbiome of rural and urban healthy Indians living in sea level and high altitude areas","volume":"8","author":"das","year":"2018","journal-title":"Sci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"101998","DOI":"10.1016\/j.psj.2022.101998","article-title":"Altitude-adaption of gut microbiota in Tibetan chicken","volume":"101","author":"Du","year":"2022","journal-title":"Poult. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1124\/dmd.121.000681","article-title":"Exposure to high-altitude environment is associated with drug transporters change: microRNA-873-5p-mediated alteration of function and expression levels of drug transporters under hypoxia","volume":"50","author":"Duan","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1159\/000332975","article-title":"Gut microbiota and its pathophysiology in disease paradigms","volume":"29","author":"Festi","year":"2011","journal-title":"Dig. Dis."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.smhs.2023.03.003","article-title":"Effects of high\u2212\/low-temperature and high-altitude hypoxic environments on gut microbiota of sports people: a retrospective analysis","volume":"5","author":"Geng","year":"2023","journal-title":"Sports Med. 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Hepatol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e117427","DOI":"10.1371\/journal.pone.0117427","article-title":"Characterization of the gut microbiota of Papua new Guineans using reverse transcription quantitative PCR","volume":"10","author":"Greenhill","year":"2015","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/10408398.2011.584134","article-title":"Importance of functional ingredients in yak milk-derived food on health of Tibetan nomads living under high-altitude stress: a review","volume":"54","author":"Guo","year":"2014","journal-title":"Crit. Rev. Food Sci. 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Spectr."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1136845","DOI":"10.3389\/fmicb.2023.1136845","article-title":"Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Microbiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"G1003","DOI":"10.1152\/ajpgi.00253.2018","article-title":"Associations between the gut microbiota and host responses to high altitude","volume":"315","author":"Karl","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fmicb.2018.02013","article-title":"Effects of psychological, environmental and physical stressors on the gut microbiota","volume":"9","author":"Karl","year":"2013","journal-title":"Front. 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USA"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2096994","DOI":"10.1080\/19490976.2022.2096994","article-title":"Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent gammadelta T cells","volume":"14","author":"Li","year":"2022","journal-title":"Gut Microbes"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1038\/srep14682","article-title":"Comparative analyses of fecal microbiota in Tibetan and Chinese Han living at low or high altitude by barcoded 454 pyrosequencing","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1111\/jeb.13924","article-title":"Recent progress in research on the gut microbiota and highland adaptation on the Qinghai-Tibet plateau","volume":"34","author":"Liu","year":"2021","journal-title":"J. Evol. Biol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3892\/etm.2016.4012","article-title":"Establishment and evaluation of an experimental rat model for high-altitude intestinal barrier injury","volume":"13","author":"Luo","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2019.05.085","article-title":"Gut microbiota adaptation to high altitude in indigenous animals","volume":"516","author":"Ma","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e1256","DOI":"10.1002\/brb3.1256","article-title":"Long-term exposure to high altitude attenuates verbal and spatial working memory: evidence from an event-related potential study","volume":"9","author":"Ma","year":"2019","journal-title":"Brain Behav."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"50","DOI":"10.5740\/jaoacint.SGE_Macfarlane","article-title":"Bacteria, colonic fermentation, and gastrointestinal health","volume":"95","author":"Macfarlane","year":"2012","journal-title":"J. AOAC Int."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.yhbeh.2016.10.006","article-title":"The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation","volume":"88","author":"Mackos","year":"2017","journal-title":"Horm. Behav."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"16431","DOI":"10.1073\/pnas.1419136111","article-title":"Rapid changes in the gut microbiome during human evolution","volume":"111","author":"Moeller","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"6342","DOI":"10.1038\/ncomms7342","article-title":"Fat, fibre and cancer risk in African Americans and rural Africans","volume":"6","author":"O\u2019Keefe","year":"2015","journal-title":"Nat. Commun."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1038\/ncomms7505","article-title":"Subsistence strategies in traditional societies distinguish gut microbiomes","volume":"6","author":"Obregon-Tito","year":"2015","journal-title":"Nat. Commun."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1017\/S0007114512005235","article-title":"Linking the gut microbiota to human health","volume":"109","author":"Robles","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.3390\/microorganisms8111744","article-title":"Intestinal barrier function in health and disease-any role of SARS-CoV-2?","volume":"8","author":"Sharma","year":"2020","journal-title":"Microorganisms"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","article-title":"The central nervous system and the gut microbiome","volume":"167","author":"Sharon","year":"2016","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.3390\/nu12092808","article-title":"Effects of human Milk oligosaccharides on the adult gut microbiota and barrier function","volume":"12","author":"\u0160uligoj","year":"2020","journal-title":"Nutrients"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1002\/jsfa.13001","article-title":"Nutritional and potential health benefits of fermented food proteins","volume":"104","author":"Tachie","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e195643","DOI":"10.1371\/journal.pone.0195643","article-title":"A snapshot of gut microbiota of an adult urban population from Western region of India","volume":"13","author":"Tandon","year":"2018","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1042\/BST20200250","article-title":"Post-transcriptional control of mitochondrial protein composition in changing environmental conditions","volume":"48","author":"Tsuboi","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"G155","DOI":"10.1152\/ajpgi.00066.2012","article-title":"Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention","volume":"303","author":"van Wijck","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1017\/S0954422415000037","article-title":"Towards microbial fermentation metabolites as markers for health benefits of prebiotics","volume":"28","author":"Verbeke","year":"2015","journal-title":"Nutr. Res. Rev."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"4850","DOI":"10.1111\/febs.16409","article-title":"Gut microbiota imbalance mediates intestinal barrier damage in high-altitude exposed mice","volume":"289","author":"Wang","year":"2022","journal-title":"FEBS J."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"953234","DOI":"10.3389\/fmicb.2022.953234","article-title":"High-altitude drives the convergent evolution of alpha diversity and Indicator microbiota in the gut microbiomes of ungulates","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e17082","DOI":"10.1371\/journal.pone.0017082","article-title":"Application of GFAT as a novel selection marker to mediate gene expression","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13099-016-0099-z","article-title":"Global investigation of composition and interaction networks in gut microbiomes of individuals belonging to diverse geographies and age-groups","volume":"8","author":"Yadav","year":"2016","journal-title":"Gut. Pathog."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00221-010-2494-x","article-title":"Prolonged high-altitude residence impacts verbal working memory: an fMRI study","volume":"208","author":"Yan","year":"2011","journal-title":"Exp. 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