{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:50:27Z","timestamp":1792183827483,"version":"4.4.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    is a foodborne pathogen associated with both typhoid and non-typhoid illness in humans and animals. This problem is further exacerbated by the emergence of antibiotic-resistant strains of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    . Therefore, to meet public health and safety, there is a need for an alternative strategy to tackle antibiotic-resistant bacteria. Bacteriophages or (bacterial viruses), due to their specificity, self-dosing, and antibiofilm activity, serve as a better approach to fighting against drug-resistant bacteria. In the current study, a broad-host range lytic phage phiSalP219 was isolated against multidrug-resistant\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serotypes Paratyphi from a pond water sample.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage phiSalP219 was able to lyse 28\/30 tested strains of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    .\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage phiSalP219 exhibits activity in acidic environments (pH3) and high temperatures (70\u00b0C). Electron microscopy and genome analysis revealed that phage phiSalP219 is a member of class\n                    <jats:italic>Caudoviricetes<\/jats:italic>\n                    . The genome of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage phiSalP219 is 146Kb in size with 44.5% GC content. A total of 250 Coding Sequence (CDS) and 25 tRNAs were predicted in its genome. Predicted open reading frames (ORFs) were divided into five groups based on their annotation results: (1) nucleotide metabolism, (2) DNA replication and transcription, (3) structural proteins, (4) lysis protein, and (5) other proteins. The absence of lysogeny-related genes in their genome indicates that\n                    <jats:italic>Salmonella<\/jats:italic>\n                    phage phiSalP219 is lytic in nature. Phage phiSalP219 was also found to be microbiologically safe (due to the absence of toxin or virulence-related genes) in the control of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhimurium infections in the ready-to-eat meat and also able to eradicate biofilm formed by the same bacterium on the borosilicate glass surface.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2024.1387830","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T05:49:36Z","timestamp":1723700976000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["A novel lytic phage infecting MDR Salmonella enterica and its application as effective food biocontrol"],"prefix":"10.3389","volume":"15","author":[{"given":"Anu Bala","family":"Jaglan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikant","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhavi","family":"Vashisth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Virmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C.","family":"Bera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Vaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taruna","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/v9040070","article-title":"How to name and classify your phage: an informal guide","volume":"9","author":"Adriaenssens","year":"2017","journal-title":"Viruses"},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3109\/1040841X.2014.880662","article-title":"Antimicrobial resistance in Salmonella enterica serovar typhi and paratyphi in South Asia-current status, issues and prospects","volume":"41","author":"Akhtar","year":"2015","journal-title":"Critical reviews in microbiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"D517","DOI":"10.1093\/nar\/gkz935","article-title":"CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database","volume":"48","author":"Alcock","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/1751-7915.12316","article-title":"A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions","volume":"9","author":"Alves","year":"2016","journal-title":"Microb. 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